Benzodiazepines and anxiety sensitivity in panic disorder
Abstract
1. Benzodiazepines were discontinued in 16 patients who had recovered from panic disorder with agoraphobia after exposure treatment. 2. Drug discontinuation yielded a significant decrease in anxiety sensitivity and state anxiety in these long-term users. 3. Several likely explanations for the findings are discussed. 4. In the short term, treatment of panic disorder with benzodiazepines may lower anxiety symptoms. However, in the long run, it may decrease the individual tolerance to anxiety and discomfort.
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Clonazepam has a long elimination half-life and induced less frequently rebound anxiety than alprazolam.
“Clonazepam [73-76] has a long elimination half-life, induced less frequently rebound anxiety than alprazolam [77].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [74]
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Self-citation
- Authors
- Fava, G. A., Grandi, S., Belluardo, P., Savron, G., Raffi, A. R., Conti, S., & Saviotti, F. M.
- Affiliations
- University at Buffalo, State University of New York (US)
- University of Bologna (IT)
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 18
- Issue
- 7
- Pages
- 1163-1168
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2071908356
- Cited by
- 32
- References
- 15
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- benzodiazepines, anxiety sensitivity, panic disorder, agoraphobia, benzodiazepine discontinuation, state anxiety, exposure therapy, long-term benzodiazepine use
- MeSH terms
- Adult, Agoraphobia, Anxiety, Benzodiazepines, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Substance Withdrawal Syndrome, Anti-Anxiety Agents, Panic Disorder
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