Inflammation and the Alteration of B-Cell Physiology in Aging
Abstract
Aging results for the immune system in a departure from the optimal homeostatic state seen in young organisms. This divergence regrettably contributes to a higher frequency of compromised responses to infections and inefficient classical vaccination in aged populations. In B cells, the cornerstone of humoral immunity, the development and distribution of the various mature B cell subsets are impacted by aging in both humans and mice. In addition, aged mature B cells demonstrate limited capacity to mount efficient antibody responses. An expected culprit for the decline in effective immunity is the rise of the systemic levels of pro-inflammatory molecules during aging, establishing a chronic low-grade inflammation. Indeed, numerous alterations affecting directly or indirectly B cells in old people and mice are reminiscent of various effects of acute inflammation on this cell type in young adults. The present mini-review will highlight the possible adverse contributions of the persistent low-level inflammation observed in susceptible older organisms to the inadequate B-cell physiology.
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Age-related remodeling of the B cell compartment may be the result of unbalanced fate selection in the hematopoietic progenitor cell population, autonomous changes in B cells, and external signals.
“The age-related remodeling of the B cell compartment may be the result of unbalanced fate selection in the hematopoietic progenitor cell population, autonomous changes in B cells, and external signals [138, 139].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [138]
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Self-citation
- Authors
- Hagen, M., & Derudder, E.
- Affiliations
- Universität Innsbruck (AT)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2019-09-25
- Volume
- 66
- Issue
- 2
- Pages
- 105-113
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2976455003
- Cited by
- 58
- References
- 60
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 10
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- aging, B cells, low-grade inflammation, humoral immunity, antibody response, B cell subsets, immunosenescence, proinflammatory molecules, acute inflammation, vaccine response
- MeSH terms
- Aged, Aging, Animals, B-Lymphocytes, Cell Physiological Phenomena, Humans, Immune System, Inflammation, Mice
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