The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective
Open accessAbstract
The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.
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“However, IGF-I concentrations are also influenced by a variety of other factors and should be used as a diagnostic tool with caution, as there is a large overlap in IGF-I production between patients with GHD and those who are GH sufficient, particularly in very young children.3,74,88,89”
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“Advantages of the macimorelin test include easy oral dosing and fewer blood draws74; however, macimorelin is a more expensive diagnostic agent than other options.76”
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“The GHRH + arginine and GHRH + GHRP-6 tests cannot detect GHD of hypothalamic origin and are unavailable in many countries.25,74”
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“Very low IGF-I concentrations are suggestive of GHD and it has been reported that IGF-I concentrations >0 standard deviation score (SDS) make GHD unlikely at any age.74,87”
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“Sex steroids induce GH secretion, and children in puberty are less likely to test as GH-deficient compared with prepubertal children.74,93”
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Richards, S., Aziz, N., Bale, S., Bick, D., Das, S., Gastier-Foster, J., Grody, W. W., Hegde, M., Lyon, E., Spector, E., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.30 · Cited by 32,594
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101
Self-citationSklar, C. A., Antal, Z., Chemaitilly, W., Cohen, L. E., Follin, C., Meacham, L. R., & Murad, M. H. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01175 · Cited by 224
Self-citationDarzy, K. H., Aimaretti, G., Wieringa, G., Gattamaneni, H. R., Ghigo, E., & Shalet, S. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021094 · Cited by 182
Dassa, Y., Crosnier, H., Chevignard, M., Viaud, M., Personnier, C., Flechtner, I., Meyer, P., Puget, S., Boddaert, N., Breton, S., et al. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0034 · Cited by 37
IGF-I resistance and Turner's syndrome
Lebl, J., Průhová, S., Zapletalová, J., & Pechová, M. (2001) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2001.14.1.37 · Cited by 24
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Boguszewski, M. C. S., Boguszewski, C. L., Chemaitilly, W., Cohen, L. E., Gebauer, J., Higham, C., Hoffman, A. R., Polak, M., Yuen, K. C. J., Alos, N., et al. (2022) · European Journal of Endocrinology · doi:10.1530/eje-21-1186 · Cited by 117
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Wexler, T. L., Reifschneider, K., Backeljauw, P., Cárdenas, J. F., Hoffman, A. R., Miller, B. S., & Yuen, K. C. J. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0384 · Cited by 19
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Metadata
- Authors
- Collett-Solberg, P. F., Ambler, G., Backeljauw, P. F., Bidlingmaier, M., Biller, B. M. K., Boguszewski, M. C. S., Cheung, P. T., Choong, C. S. Y., Cohen, L. E., Cohen, P., Dauber, A., Deal, C. L., Gong, C., Hasegawa, Y., Hoffman, A. R., Hofman, P. L., Horikawa, R., Jorge, A. A. L., Juul, A., Kamenický, P., Khadilkar, V., Kopchick, J. J., Kriström, B., Lopes, M. D. L. A., Luo, X., Miller, B. S., Misra, M., Netchine, I., Radovick, S., Ranke, M. B., Rogol, A. D., Rosenfeld, R. G., Saenger, P., Wit, J. M., & Woelfle, J.
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2019
- Volume
- 92
- Issue
- 1
- Pages
- 1-14
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2973019498
- Cited by
- 360
- References
- 6
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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