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Cited by 12Pituitary Gland Disorders and TreatmentsRegulation of Appetite and ObesityEating Disorders and Behaviors

Evaluating eating behaviour, energy homeostasis, and obesity in childhood-onset craniopharyngioma: a feasibility study

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Hinton, Elanor C., Lithander, Fiona E, Elsworth, Rebecca L, Hawton, Katherine, Narayan, Kruthika, Szymkowiak, Sophie, Bedford, Holly L, Naeem, Nimra +4 more·2024·Hormone Research in Paediatrics
DOI 10.1159/000530863PMC PMC10777714

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Abstract

Introduction: Craniopharyngiomas are rare brain tumours (incidence 1.1–1.7 cases/million/year). Although non-malignant, craniopharyngioma causes major endocrine and visual morbidities including hypothalamic obesity, yet mechanisms leading to obesity are poorly understood. This study investigated the feasibility and acceptability of eating behaviour measures in patients with craniopharyngioma to inform the design of future trials. Methods: Patients with childhood-onset craniopharyngioma and controls matched for sex, pubertal stage, and age were recruited. After an overnight fast, participants received the following measures: body composition, resting metabolic rate, oral glucose tolerance test including magnetic resonance imaging (patients only), appetite ratings, eating behaviour, and quality of life questionnaires, ad libitum lunch, and an acceptability questionnaire. Data are reported as median ± IQR, with effect size measure (Cliff’s delta) and Kendall’s tau for correlations, due to the small sample size. Results: Eleven patients (median age = 14 years; 5 F/6 M) and matched controls (median age = 12 years; 5 F/6 M) were recruited. All patients had received surgery, and 9/11 also received radiotherapy. Hypothalamic damage post-surgery was graded (Paris grading): grade 2 n = 6; grade 1 n = 1; grade 0 n = 2. The included measures were deemed highly tolerable by participants and their parent/carers. Preliminary data suggest a difference in hyperphagia between patients and controls (d = 0.5), and a relationship between hyperphagia with body mass index standard deviation score (BMISDS) in patients (τ = 0.46). Discussion: These findings demonstrate that eating behaviour research is feasible and acceptable to craniopharyngioma patients and there is an association between BMISDS and hyperphagia in patients. Thus, food approach and avoidance behaviours may be useful targets for interventions to manage obesity in this patient group.

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  • The effect of hyperphagia behaviors is decreased quality of life for affected individuals and increased burden for caretakers; obesity without hyperphagia does not have the same effects.

    “The effect of these hyperphagia behaviors is decreased quality of life for affected individuals and increased burden for caretakers; obesity without hyperphagia does not have the same effects (84).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [84]

    The Discussion (page not provided) reports that parents rated quality of life lower for young people with greater hyperphagic behaviours, but the young people’s own ratings did not show that relationship. The paper does not establish that hyperphagia causes lower quality of life, measure increased caretaker burden, or compare these effects with obesity without hyperphagia. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Individuals with hyperphagia spend more time "talking or engaging with food" than those without hyperphagia, and food interferes with daily functioning.

    “Individuals with hyperphagia spend more time “talking or engaging with food” than those without hyperphagia, and food interferes with daily functioning (84).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [84]

    The Results section ('Preliminary Data with Matched Controls') reports more time spent talking or engaging with food and greater interference with daily functioning in patients with childhood-onset craniopharyngioma than in matched controls. It also reports greater hyperphagia in the patient group, but it does not compare individuals classified as having hyperphagia with those without it. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

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Authors
Hinton, E. C., Lithander, F. E., Elsworth, R. L., Hawton, K., Narayan, K., Szymkowiak, S., Bedford, H. L., Naeem, N., Elson, R., Taylor-Miller, T., Hamilton-Shield, J. P., & Crowne, E. C.
Affiliations
  • University of Bristol (GB)
  • University of Auckland (NZ)
  • University Hospitals Bristol NHS Foundation Trust (GB)
Corresponding author
Hinton, Elanor C.
ORCID
Venue
Hormone Research in Paediatrics
Publisher
S. Karger AG
Published
2023-05-17
Volume
97
Issue
1
Pages
80-93
ISSN
  • 1663-2818 (ISSN-L)
  • 1663-2826
DOI
10.1159/000530863
PMC
PMC10777714
OpenAlex
W4378348055
Cited by
12
References
2
Citations by year
2026: 9 · 2025: 1 · 2023: 2
FWCI
2.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Hormone Research in Paediatrics (publishedVersion, cc-by-nc)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion, cc-by-nc)
  • Explore Bristol Research (submittedVersion, cc-by-nc)
Funders
  • National Institute for Health and Care Research
  • Department of Health and Social Care
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
craniopharyngioma, childhood-onset craniopharyngioma, hypothalamic obesity, eating behaviour, hyperphagia, energy homeostasis, body composition, resting metabolic rate, glucose tolerance, appetite, body mass index, feasibility, acceptability
MeSH terms
Adolescent, Child, Craniopharyngioma, Feasibility Studies, Feeding Behavior, Homeostasis, Humans, Hyperphagia, Pituitary Neoplasms, Quality of Life, Pediatric Obesity

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