Evaluation of the neonatal sequential organ failure assessment and mortality risk in neonates with early-onset infection
Open accessAbstract
BACKGROUND: The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown. OBJECTIVES: The objective of the study was to determine the utility of nSOFA for EOS mortality. METHODS: Multicenter, retrospective cohort study of NICU patients with EOS between 2012 and 2023. nSOFA scores of survivors and non-survivors were compared, and area under the receiver operating characteristics curve (AUROC) for mortality was calculated. RESULTS: 104 subjects were identified (88 lived, 16 died). AUROC at blood culture collection (T0), 6 h after collection (T6), and the maximum nSOFA at T0 or T6 (T0-6max) were 0.76 (95% CI: 0.62, 0.91), 0.89 (0.80, 0.99), and 0.87 (0.77, 0.97), respectively. Analyses restricted to birthweight (<1.5, <1 kg) or gestational age (<32, <29 week) cutoffs revealed AUROC ranges of 0.86-0.92 for T6 and 0.82-0.84 for T0-6max. CONCLUSIONS: The nSOFA showed good-to-excellent discrimination of mortality among infants with EOS in the NICU.
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The nSOFA has strong utility to predict disease-specific mortality across sepsis and necrotizing enterocolitis.
“as well as disease-specific mortality across sepsis and necrotizing enterocolitis (13–15).”
From Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy (2026) · cites this paper as [15]
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Cites
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Lagnese, K., Sheth, S., Vice, S., Rajderkar, D., Roig, J. C., Weiss, M., & Wynn, J. L. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1844058
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- Authors
- Yeo, K. T., Goh, G. L., Park, W. Y., Wynn, J. L., & Aziz, K. B.
- Affiliations
- SingHealth (SG)
- KK Women's and Children's Hospital (SG)
- Johns Hopkins University (US)
- University of Florida Health (US)
- Venue
- Neonatology
- Publisher
- S. Karger AG
- Published
- 2023
- Volume
- 120
- Issue
- 6
- Pages
- 796-800
- ISSN
- 1661-7800 (ISSN-L)
- 1661-7819
- PMC
- PMC13202496
- OpenAlex
- W4387116261
- Cited by
- 13
- References
- 14
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 2
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Neonatology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- U.S. National Library of Medicine (T15LM013979)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- early-onset sepsis, neonatal mortality, mortality prediction, organ dysfunction, neonatal intensive care, low birth weight infants, gestational age
- MeSH terms
- Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Retrospective Studies, Hospital Mortality, Sepsis, Organ Dysfunction Scores
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