Multicenter validation of the neonatal sequential organ failure assessment score for prognosis in the neonatal intensive care unit
Open accessAbstract
Infants in the neonatal intensive care unit are at risk of life-threatening organ dysfunction, but few objective tools with utility exist. In a multicenter cohort of 20 152 infants, we show the neonatal sequential organ failure assessment score had good-to-excellent discrimination of mortality across centers, birth weights, and time points after admission.
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The nSOFA has strong utility to predict all-cause mortality, including in extremely low birth weight infants.
“Validated in multicenter studies, the nSOFA has strong utility to predict all-cause mortality (11) including ELBWs (12)”
From Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy (2026) · cites this paper as [11]
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The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012
Stoll, B. J., Hansen, N. I., Bell, E. F., Walsh, M. C., Carlo, W. A., Shankaran, S., Laptook, A. R., Sánchez, P. J., Van Meurs, K. P., Wyckoff, M., et al. (2015) · JAMA · doi:10.1001/jama.2015.10244 · Cited by 2,791 · see citing works
Matics, T. J., & Sanchez-Pinto, L. N. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.2352 · Cited by 676 · see citing works
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Wynn, J. L., & Polin, R. A. (2020) · Pediatric Research · doi:10.1038/s41390-019-0517-2 · Cited by 169 · see citing works
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Sanchez-Pinto, L. N., Parker, W. F., Mayampurath, A. M., Derrington, S. F., & Michelson, K. N. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004774 · Cited by 11 · see citing works
Self-citationLemmon, M. E., Truog, R. D., & Ubel, P. A. (2020) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.5215 · Cited by 5 · see citing works
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- Authors
- Wynn, J. L., Mayampurath, A., Carey, K., Slattery, S., Andrews, B., & Sanchez-Pinto, L. N.
- Affiliations
- University of Florida Health (US)
- University of Chicago (US)
- Northwestern University (US)
- Corresponding author
- Wynn, James L.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 236
- Pages
- 297-300.e1
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC9045002
- OpenAlex
- W3160356149
- Cited by
- 37
- References
- 9
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 1
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K01HL148390, R21HD096402)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- SOFA score, neonatal intensive care, organ dysfunction, mortality prediction, prognostic score validation, multicenter validation, birth weight, neonatal mortality
- MeSH terms
- Birth Weight, Florida, Humans, Illinois, Infant, Infant Mortality, Infant, Newborn, Intensive Care Units, Neonatal, Prognosis, Cohort Studies, Hospital Mortality, Organ Dysfunction Scores
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