Inflammation and thrombosis – testing the hypothesis with anti- inflammatory drug trials

Inflammation in atherosclerosis

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Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Extracellular DNA traps promote thrombosis

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Mechanisms of plaque formation and rupture

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The immune system in atherosclerosis

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C-Reactive Protein Levels and Outcomes after Statin Therapy

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Thrombosis as an intravascular effector of innate immunity

Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989 · see citing works

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

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Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

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Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

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Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

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Bidirectional Relation Between Inflammation and Coagulation

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Fibrinogen as a key regulator of inflammation in disease

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Neutrophil extracellular traps promote deep vein thrombosis in mice

Brill, A. G., Fuchs, T. A., Savchenko, A. S., Thomas, G. M., Martinod, K., Meyer, S. F. D., Bhandari, A. A., & Wagner, D. D. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04544.x · Cited by 900 · see citing works

Thrombosis: tangled up in NETs

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Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

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Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799 · see citing works

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

Ridker, P. M., Rifai, N., & Clearfield, M. B. (2001) · ACC Current Journal Review · doi:10.1016/s1062-1458(01)00460-3 · Cited by 762 · see citing works

A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism

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Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation

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An Association between Atherosclerosis and Venous Thrombosis

Prandoni, P., Bilora, F., Marchiori, A., Bernardi, E., Petrobelli, F., Lensing, A. W. A., Prins, M. H., & Girolami, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022157 · Cited by 651 · see citing works

Inflammation and Thrombosis

Libby, P., & Simon, D. I. (2001) · Circulation · doi:10.1161/01.cir.103.13.1718 · Cited by 605 · see citing works

Cross Talk Pathways Between Coagulation and Inflammation

Foley, J. H., & Conway, E. M. (2016) · Circulation Research · doi:10.1161/circresaha.116.306853 · Cited by 585 · see citing works

Stabilization of atherosclerotic plaques: New mechanisms and clinical targets

Libby, P., & Aikawa, M. (2002) · Nature Medicine · doi:10.1038/nm1102-1257 · Cited by 581 · see citing works

Anti-inflammatory therapies for cardiovascular disease

Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 558 · see citing works

Fibrin Clot Structure and Function

Undas, A., & Ariëns, R. A. S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230631 · Cited by 526 · see citing works

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

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Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

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Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

Borissoff, J. I., Joosen, I. A., Versteylen, M. O., Brill, A. G., Fuchs, T. A., Savchenko, A. S., Gallant, M., Martinod, K., Cate, H. T., Hofstra, L., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301627 · Cited by 448 · see citing works

Inflammation and thrombosis

Esmon, C. T. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00261.x · Cited by 442 · see citing works

Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions

Mason, J. C., & Libby, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu403 · Cited by 420 · see citing works

Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study

Sørensen, H. T., Horváth–Puhó, E., Pedersen, L. H., Baron, J. A., & Prandoni, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61745-0 · Cited by 398 · see citing works

InflammasomesPreprint

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Inflammation and Immunity in Diseases of the Arterial Tree: Players and Layers

Libby, P., & Hansson, G. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.301313 · Cited by 372 · see citing works

Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis

Everett, B. M., Pradhan, A. D., Solomon, D. H., Paynter, N., MacFadyen, J., Zaharris, E., Gupta, M., Clearfield, M., Libby, P., Hasan, A. A. K., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.018 · Cited by 368 · see citing works

Altered Fibrin Architecture Is Associated With Hypofibrinolysis and Premature Coronary Atherothrombosis

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Two-Way Interactions Between Inflammation and Coagulation

Levi, M. M., & van der Poll, T. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.07.004 · Cited by 334 · see citing works

Inflammation-Induced Thrombosis: Mechanisms, Disease Associations and Management

Keser, G. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504731 · Cited by 326 · see citing works

Platelets as Cellular Effectors of Inflammation in Vascular Diseases

Rondina, M. T., Weyrich, A. S., & Zimmerman, G. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.300512 · Cited by 315 · see citing works

Residual inflammatory risk: addressing the obverse side of the atherosclerosis prevention coin

Ridker, P. M. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw024 · Cited by 309 · see citing works

The cytokine‐mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia

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Intertwining of thrombosis and inflammation in atherosclerosis

Croce, K., & Libby, P. (2007) · Current Opinion in Hematology · doi:10.1097/00062752-200701000-00011 · Cited by 285 · see citing works

Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)

Ridker, P. M. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03404.x · Cited by 269 · see citing works

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

Savchenko, A. S., Martinod, K., Seidman, M. A., Wong, S. L., Borissoff, J. I., Piazza, G., Libby, P., Goldhaber, S. Z., Mitchell, R. N., & Wagner, D. D. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12571 · Cited by 268 · see citing works

Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives

Undas, A., Zawilska, K., Cieśla‐Dul, M., Lehmann-Kopydłowska, A., Skubiszak, A., Ciepłuch, K., & Tracz, W. (2009) · Blood · doi:10.1182/blood-2009-05-222380 · Cited by 260 · see citing works

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial

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Cardiovascular Event Reduction and Adverse Events Among Subjects Attaining Low-Density Lipoprotein Cholesterol <50 mg/dl With Rosuvastatin

Hsia, J., MacFadyen, J. G., Monyak, J., & Ridker, P. M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.082 · Cited by 231 · see citing works

Proneness to Formation of Tight and Rigid Fibrin Gel Structures in Men with Myocardial Infarction at a Young Age

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Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials

Naci, H., Brugts, J. J., Fleurence, R., Tsoi, B., Toor, H., & Ades, A. (2013) · European Journal of Preventive Cardiology · doi:10.1177/2047487313480435 · Cited by 202 · see citing works

Sepsis and Thrombosis

Schultz, M. J., van der Poll, T., & Levi, M. M. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1343894 · Cited by 202 · see citing works

Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: Effects of inflammation and oxidative stress

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Fibrin(ogen) and thrombotic disease

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The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

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General mechanisms of coagulation and targets of anticoagulants (Section I)

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Inflammation and hemostasis

Margetić, S. (2012) · Biochemia Medica · doi:10.11613/bm.2012.006 · Cited by 179 · see citing works

Fibrin Gel Network Characteristics and Coronary Heart Disease: Relations to Plasma Fibrinogen Concentration, Acute Phase Protein, Serum Lipoproteins and Coronary Atherosclerosis

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Fibrinogen and red blood cells in venous thrombosis

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Inflammatory bowel disease and thromboembolism

Zezos, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i38.13863 · Cited by 160 · see citing works

CD40 Ligation Induces Tissue Factor Expression in Human Vascular Smooth Muscle Cells

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Thrombosis in vasculitis: from pathogenesis to treatment

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The role of T and B cells in human atherosclerosis and atherothrombosis

Ammirati, E., Moroni, F., Magnoni, M., & Camici, P. G. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12477 · Cited by 157 · see citing works

Risk of Venous Thromboembolism in Patients With Rheumatoid Arthritis and Association With Disease Duration and Hospitalization

Holmqvist, M. E., Neovius, M., Eriksson, J. K., Mantel, Ä., Wållberg‐Jonsson, S., Jacobsson, L., & Askling, J. (2012) · JAMA · doi:10.1001/2012.jama.11741 · Cited by 156 · see citing works

Inflammation and haemostasis.

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Risk of Venous Thromboembolism in Patients With Rheumatoid Arthritis

Kim, S. C., Schneeweiß, S., Liu, J., & Solomon, D. H. (2013) · Arthritis Care & Research · doi:10.1002/acr.22039 · Cited by 147 · see citing works

The JUPITER Trial

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Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis.

Libby, P., Salomon, R., Payne, D. D., Schöen, F. J., & Pober, J. S. (1989) · PubMed · Cited by 141 · see citing works

The risk of pulmonary embolism and deep vein thrombosis in rheumatoid arthritis: a UK population-based outpatient cohort study

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Venous Thromboembolism and Atherothrombosis An Integrated Approach

Piazza, G., & Goldhaber, S. Z. (2010) · Circulation · doi:10.1161/circulationaha.110.951236 · Cited by 133 · see citing works

Arterial Thrombosis and the Role of Thrombophilia

Boekholdt, S. M., & Kramer, M. H. H. (2007) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-985755 · Cited by 123 · see citing works

EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries

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Inflammation as a cause of venous thromboembolism

Saghazadeh, A., & Rezaei, N. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.01.007 · Cited by 120 · see citing works

Inflammation and thrombosis in cardiovascular disease

Nagareddy, P. R., & Smyth, S. S. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328364219d · Cited by 119 · see citing works

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

Robbins, G. R., Wen, H., & Ting, J. P. ‐. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.029 · Cited by 114 · see citing works

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

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Risk of venous thromboembolism occurrence among adults with selected autoimmune diseases: A study among a U.S. cohort of commercial insurance enrollees

Yusuf, H. R., Hooper, W. C., Grosse, S. D., Parker, C. S., Boulet, S. L., & Ortel, T. L. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.10.012 · Cited by 110 · see citing works

Venous thrombosis and prothrombotic factors in inflammatory bowel disease

Magro, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i17.4857 · Cited by 99 · see citing works

The role of inflammation in venous thromboembolism and the link between arterial and venous thrombosis.

Poredoš, P., & Jezovnik, M. K. (2007) · PubMed · Cited by 95 · see citing works

The Reciprocal Relationship Between Inflammation and Coagulation

O'Brien, M. (2012) · Topics in companion animal medicine · doi:10.1053/j.tcam.2012.06.003 · Cited by 89 · see citing works

Act Local, Act Global⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

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Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis

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Inherited Thrombophilia in Arterial Disease: A Selective Review

de Moerloose, P., & Boehlen, F. (2007) · Seminars in Hematology · doi:10.1053/j.seminhematol.2007.01.008 · Cited by 78 · see citing works

Venous and arterial disease in inflammatory bowel disease

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Hemostasis and inflammation: two of a kind?

Verhamme, P. B., & Hoylaerts, M. (2009) · Thrombosis Journal · doi:10.1186/1477-9560-7-15 · Cited by 69 · see citing works

Association between venous and arterial thrombosis: Clinical implications

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The relationship between unprovoked venous thromboembolism, age, and acute myocardial infarction

Spencer, F. A., Ginsberg, J. S., Chong, A. S., & Alter, D. A. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03062.x · Cited by 65 · see citing works

Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Tamaki, H., & Khasnis, A. A. (2015) · Vascular Medicine · doi:10.1177/1358863x15573838 · Cited by 62 · see citing works

Taming the inflammasome

Levy, M., Thaiss, C. A., & Elinav, E. (2015) · Nature Medicine · doi:10.1038/nm.3808 · Cited by 46 · see citing works

Risk of Venous Thromboembolism in Patients with Rheumatoid Arthritis: Initiating Disease-Modifying Antirheumatic Drugs

Kim, S. C., Solomon, D. H., Liu, J., Franklin, J. M., Glynn, R. J., & Schneeweiß, S. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.11.025 · Cited by 45 · see citing works

Activation of Blood Coagulation in Two Prototypic Autoimmune Skin Diseases: A Possible Link with Thrombotic Risk

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Endothelial dysfunction

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Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update

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Microparticles as Regulators of Cardiovascular Inflammation

Andriantsitohaina, R., Gaceb, A., Vergori, L., & Martínez, M. C. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.07.001 · Cited by 37 · see citing works

Microparticles: Bridging the Gap between Autoimmunity and Thrombosis

Niccolai, E., Emmi, G., Squatrito, D., Silvestri, E., Emmi, L., Prisco, D., & Amedei, A. (2015) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0035-1549850 · Cited by 36 · see citing works

Fanning the flames: inflammation in cardiovascular diseases

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Microvesicles at the Crossroads Between Infection and Cardiovascular Diseases

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Are Microparticles the Missing Link between Thrombosis and Autoimmune Diseases? Involvement in Selected Rheumatologic Diseases

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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

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Atherosclerosis and inflammation: overview and updates

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Inflammation, Immunity, and Infection in Atherothrombosis

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Superhydrophobic Blood‐Repellent Surfaces

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A Comparative Study of Rutin and Rutin Glycoside: Antioxidant Activity, Anti-Inflammatory Effect, Effect on Platelet Aggregation and Blood Coagulation

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The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms

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Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases

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Adenosine and the Cardiovascular System

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The Role of Inflammation in Cardiovascular Outcome

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Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis

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Platelets and von Willebrand factor in atherogenesis

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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

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Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

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Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression

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Bleeding Complications in Patients Undergoing Percutaneous Coronary Intervention

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Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities

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Colchicine and myocardial infarction: A review

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Antioxidant, Anti-Inflammatory and Antithrombotic Effects of Ginsenoside Compound K Enriched Extract Derived from Ginseng Sprouts

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Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis

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Recent advances in therapeutic targeting of inflammation in atherosclerosis

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Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study

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Aqueous extract of Paeoniae Radix Rubra prevents deep vein thrombosis by ameliorating inflammation through inhibiting GSK3β activity

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Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers

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Morroniside on anti-inflammation activities in rats following acute myocardial infarction

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Driver Genes Associated With the Incidence of Venous Thromboembolism in Patients With Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

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Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

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Vaccination for Respiratory Infections in Patients with Heart Failure

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Coagulation System Activation for Targeting of COVID-19: Insights into Anticoagulants, Vaccine-Loaded Nanoparticles, and Hypercoagulability in COVID-19 Vaccines

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Thromboinflammation and Vascular Dysfunction

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Amaranth peptides decreased the activity and expression of cellular tissue factor on LPS activated THP-1 human monocytes

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Combining Colchicine and Antiplatelet Therapy to Tackle Atherothrombosis: A Paradigm in Transition?

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Metabolomic profiling of deep vein thrombosis

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Evaluation of low-dose colchicine in patients with cardiopulmonary bypass: study protocol for a randomised controlled trial

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Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression

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Incident Gout and Risk of First‐Time Acute Coronary Syndrome: A Prospective, Population‐Based Cohort Study in Sweden

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Potential causal relationships between blood metabolites, inflammatory cytokines, and venous thromboembolism

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First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

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Dysfunction of aorta is prevented by whey protein concentrate-80 in venous thrombosis-induced rats

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Infections and inflammation in the development of stroke

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Vaccination in patients with heart failure in practice

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Ticagrelor versus clopidogrel in reducing inflammatory cell infiltration of thrombus aspirated in patients with ST-elevation myocardial infarction

Shen, J., Liu, G., Wu, G., Sheng, L., Cao, Z., Guo, S., Dong, S., Sun, X., & Tian, Y. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-022-03348-5 · Cited by 6 · see citing works

Depression and myocardial injury in ST-segment elevation myocardial infarction: A cardiac magnetic resonance imaging study

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Immunologic and inflammatory pathogenesis of chronic coronary syndromes: A review

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An Exploration of Anti-Inflammatory Therapy in Acute/Subacute Severe Cerebral Venous Thrombosis with Hereditary Protein C/S Deficiency: Case Series

Hao, W., Gu, Y., Hu, S., Ji, X., Wang, Y., & Duan, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s428589 · Cited by 4 · see citing works

Effect of cardiac rehabilitation on mortality related inflammatory markers

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A novel cyanoacrylate-based matrix excipient in HPMCP capsules forms a sustained intestinal delivery system for orally administered drugs with enhanced absorption efficiency

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Colchicine in acute coronary syndromes: a systematic review and meta-analysis of randomised controlled trials

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Clustering of blood cell count abnormalities and future risk of death

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INDICATORS OF NONSPECIFIC SYSTEMIC INFLAMMATION AS CRITERIA FOR DESTABILIZATION OF THE COURSE OF CORONARY ARTERY DISEASE

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Effect of the Anti-inflammatory and Antioxidant Effects of Salvia miltiorrhiza On Diabetic Nephropathy in Induced Diabetic Rats

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CRITERIA FOR DESTABILIZATION OF THE DISEASE COURSE IN PATIENTS WITH CORONARY HEART DISEASE

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PROGNOSTIC SIGNIFICANCE OF NON-SPECIFIC SYSTEMIC INFLAMMATION MARKERS IN PATIENTS WITH CORONARY HEART DISEASE

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Administration of Slit2 analogs to minimize vascular injuries, inflammation, and kidney involvement in β-thalassemia: A hypothesis

Noulsri, E., & Lerdwana, S. (2024) · Medical Hypotheses · doi:10.1016/j.mehy.2024.111547

Research Progress on the Predictive Value of Composite Inflammatory Indicators for Intermuscular Venous Thrombosis in the Calf Following Intertrochanteric Fracture Surgery in Elderly Patients

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Inflammation and atherosclerotic cardiovascular disease: lights and shadows

Caterina, R. D. (2025) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/gbh7x7

A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications

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Inflammation And Atherothrombosis: The Beginning Of The End Of A Hypothesis

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Interplay between inflammation and thrombosis in cardiovascular pathology

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Anti-inflammatory therapies for cardiovascular disease

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