Inflammation and thrombosis

Esmon, C.T.

doi:10.1046/j.1538-7836.2003.00261.x

Cited by 442Blood Coagulation and Thrombosis MechanismsBlood properties and coagulationPlatelet Disorders and Treatments

Inflammation and thrombosis

Open access

Esmon, C.T.·2003·Journal of Thrombosis and Haemostasis

DOI 10.1046/j.1538-7836.2003.00261.x

Open this paper in CoChat — free account Open PDF

Abstract

Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms upregulate procoagulant factors, downregulate natural anticoagulants and inhibit fibrinolytic activity. In addition to modulating plasma coagulation mechanisms, inflammatory mediators appear to increase platelet reactivity. In vivo, however, natural anticoagulants not only prevent thrombosis, but they also dampen inflammatory activity. Some insights into the evolution and linkages between inflammatory mechanisms and the coagulation/anticoagulation mechanisms have become evident from recent structural studies. This review will summarize the interactions between inflammation and coagulation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.1538-7836.2003.00261.x

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Estrogens have a divergent effect on inflammation and immune modulation based on the dose and duration of treatment.
“Estrogens have a divergent effect on inflammation and immune modulation [74, 75] based on the dose and duration of treatment of the drug.”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [75]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Activated Protein C Reduces the Severity of Compression-Induced Spinal Cord Injury in Rats by Inhibiting Activation of Leukocytes
Taoka, Y., Okajima, K., Uchiba, M., Murakami, K., Harada, N., Johno, M., & Naruo, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01393.1998 · Cited by 116 · see citing works
Retracted
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., MÜLLER‐BERGHAUS, G., & Kroczek, R. A. (1998) · Nature · doi:10.1038/35393 · Cited by 2,082 · see citing works
Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.
Drake, T. A., Morrissey, J. H., & Edgington, T. S. (1989) · Europe PMC (PubMed Central) · Cited by 1,192 · see citing works
Blood-borne tissue factor: Another view of thrombosis
Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimón, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2311 · Cited by 990 · see citing works
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Riewald, M., Petrovan, R. J., Donner, A. J., Mueller, B. M., & Ruf, W. (2002) · Science · doi:10.1126/science.1071699 · Cited by 832 · see citing works
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.
Taylor, F. B., Chang, A. C. K., Esmon, C. T., D’Angelo, A., Vigano’D’Angelo, S., & Blick, K. E. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112902 · Cited by 820 · see citing works
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
Palabrica, T. M., Lobb, R. R., Furie, B. C., Aronovitz, M. J., Benjamin, C. D., Hsu, Y., Sajer, S. A., & Furie, B. (1992) · Nature · doi:10.1038/359848a0 · Cited by 811 · see citing works
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism
André, P., Prasad, K. S. S., Denis, C. V., He, M.-S., Papalia, J. M., Hynes, R. O., Phillips, D. R., & Wagner, D. D. (2002) · Nature Medicine · doi:10.1038/nm0302-247 · Cited by 725 · see citing works
Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis
Faust, S. N., Levin, M., Harrison, O. B., Goldin, R. D., Lockhart, M. S., Kondaveeti, S., Laszik, Z. G., Esmon, C. T., & Heyderman, R. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108093450603 · Cited by 688 · see citing works
Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.
Sims, P. J., Faioni, E. M., Wiedmer, T., & Shattil, S. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81346-7 · Cited by 673 · see citing works
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis
Joyce, D. E., Gelbert, L., Ciaccia, A., DeHoff, B., & Grinnell, B. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100017200 · Cited by 649 · see citing works
TAFI, or Plasma Procarboxypeptidase B, Couples the Coagulation and Fibrinolytic Cascades through the Thrombin-Thrombomodulin Complex
Bajzar, L., Morser, J., & Nesheim, M. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16603 · Cited by 649 · see citing works
Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils.
Lorant, D. E., Patel, K. D., McIntyre, T. M., McEver, R. P., Prescott, S. M., & Zimmerman, G. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.1.223 · Cited by 576 · see citing works
The Structural Biology of Expression and Function of Tissue Factor
Edgington, T. S., Mackman, N., Brand, K., & Ruf, W. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646375 · Cited by 550 · see citing works
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
Fukudome, K., & Esmon, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47220-1 · Cited by 520 · see citing works
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
Moody, D. B., Ulrichs, T., Mühlecker, W., Young, D. C., Gurcha, S. S., Grant, E. P., Rosat, J., Brenner, M. B., Costello, C. E., Besra, G. S., et al. (2000) · Nature · doi:10.1038/35009119 · Cited by 456 · see citing works
Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
Fisher, C. J., & Yan, S.-C. B. (2000) · Critical Care Medicine · doi:10.1097/00003246-200009001-00011 · Cited by 416 · see citing works
Tumor Necrosis Factor Suppresses Transcription of the Thrombomodulin Gene in Endothelial Cells
Conway, E. M., & ROSENBERG, R. D. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.12.5588-5592.1988 · Cited by 392 · see citing works
Plasma thrombomodulin in health and diseases
Takano, S., Kimura, S., Ohdama, S., & Aoki, N. (1990) · Blood · doi:10.1182/blood.v76.10.2024.bloodjournal76102024 · Cited by 377 · see citing works
Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C Anticoagulant System
Dahlbäck, B. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646373 · Cited by 358 · see citing works
Regulation of coagulation by a multivalent Kunitz-type inhibitor
Broze, G., Girard, T., & Novotny, W. F. (1990) · Biochemistry · doi:10.1021/bi00485a001 · Cited by 354 · see citing works
The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways
Conway, E. M., de Wouwer, M. V., Pollefeyt, S., Jurk, K., Aken, H. V., Vriese, A. D., Weitz, J. I., Weiler-Guettler, H., Hellings, P. W., Schaeffer, P., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020077 · Cited by 352 · see citing works
Soluble Thrombomodulin Antigen in Conditioned Medium Is Increased by Damage of Endothelial Cells
Ishii, H., Uchiyama, H., & Kazama, M. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648199 · Cited by 344 · see citing works
Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade
Morrissey, J. H., Fakhrai, H., & Edgington, T. S. (1987) · Cell · doi:10.1016/0092-8674(87)90669-6 · Cited by 325 · see citing works
Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis.
Opal, S. M., & Esmon, C. T. (2002) · Critical Care · doi:10.1186/cc1854 · Cited by 308 · see citing works
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
Taylor, F. B., Stearns-Kurosawa, D. J., Kurosawa, S., Ferrell, G. L., Chang, A. C. K., Laszik, Z. G., Kosanke, S. D., Peer, G., & Esmon, C. T. (2000) · Blood · doi:10.1182/blood.v95.5.1680.005k33_1680_1686 · Cited by 297 · see citing works
Initiation and regulation of tissue factor-dependent blood coagulation.
Rapaport, S. I., & Rao, L. V. M. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.10.1111 · Cited by 280 · see citing works
Surface expression and functional characterization of α-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin
Alberio, L., Safa, O., Clemetson, K. J., Esmon, C. T., & Dale, G. L. (2000) · Blood · doi:10.1182/blood.v95.5.1694.005k24_1694_1702 · Cited by 278 · see citing works
Tissue Factor Pathway Inhibitor Gene Disruption Produces Intrauterine Lethality in Mice
Huang, Z.-F., Higuchi, D. A., Lasky, N. M., & Broze, G. (1997) · Blood · doi:10.1182/blood.v90.3.944 · Cited by 262 · see citing works
Cytokines in the Pathogenesis of Atherosclerosis
Young, J. B., Libby, P., & Schönbeck, U. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613256 · Cited by 249 · see citing works
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.
Glaser, C. B., Morser, J., Clarke, J., Blasko, E., Mclean, K., Kuhn, I., Chang, R. J., Lin, J.-H., Vilander, L., & Andrews, W. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116151 · Cited by 233 · see citing works
Inactivation of C3a and C5a Octapeptides by Carboxypeptidase R and Carboxypeptidase N
Campbell, W. D., Lazoura, E., Okada, N., & Okada, H. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02669.x · Cited by 224 · see citing works
Activated protein C inhibits lipopolysaccharide‐induced nuclear translocation of nuclear factor κB (NF‐κB) and tumour necrosis factor α (TNF‐α) production in the THP‐1 monocytic cell line
White, B., Schmidt, M., Murphy, C., Livingstone, W. J., O’Toole, D., Lawler, M., O'Neill, L. A. J., Kelleher, D. P., Schwarz, H. P., & Smith, O. P. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02128.x · Cited by 222 · see citing works
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage
Taylor, F. B., Chang, A., Peer, G. T., Mather, T., Blick, K. E., Catlett, R., Lockhart, M. S., & Esmon, C. T. (1991) · Blood · doi:10.1182/blood.v78.2.364.364 · Cited by 211 · see citing works
The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid
Oganesyan, V., Oganesyan, N., Terzyan, S. S., Qu, D., Dauter, Z., Esmon, N. L., & Esmon, C. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200163200 · Cited by 203 · see citing works
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans–associated meningococcemia
White, B., Livingstone, W. J., Murphy, C., Hodgson, A. J., Rafferty, M., & Smith, O. P. (2000) · Blood · doi:10.1182/blood.v96.12.3719 · Cited by 195 · see citing works
Thrombomodulin Structure and Function
Sadler, J. E. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657558 · Cited by 186 · see citing works
Activated Protein C Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes
Yuksel, M., Uchiba, M., Horiuchi, S., Okabe, H., & Okajima, K. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613197 · Cited by 181 · see citing works
Metalloproteolytic Release of Endothelial Cell Protein C Receptor
Xu, J., Qu, D., Esmon, N. L., & Esmon, C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.6038 · Cited by 177 · see citing works
Characterization of the protein Z–dependent protease inhibitor
Han, X., Fiehler, R. W., & Broze, G. J. (2000) · Blood · doi:10.1182/blood.v96.9.3049 · Cited by 162 · see citing works
CD40L-CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expression
Miller, D. L., Yaron, R., & Yellin, M. J. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.3.373 · Cited by 158 · see citing works
Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells
Oelschläger, C., Römisch, J., Staubitz, A., Stauss, H. M., Leithäuser, B., Tillmanns, H., & Hölschermann, H. (2002) · Blood · doi:10.1182/blood.v99.11.4015 · Cited by 156 · see citing works
Prothrombotic phenotype of protein Z deficiency
Yin, Z.-F., Huang, Z.-F., Cui, J., Fiehler, R. W., Lasky, N. M., Ginsburg, D., & Broze, G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120081897 · Cited by 154 · see citing works
Characterization of the protein Z–dependent protease inhibitor
Han, X., Fiehler, R. W., & Broze, G. (2000) · Blood · doi:10.1182/blood.v96.9.3049.h8003049_3049_3055 · Cited by 147 · see citing works
Complex-dependent inhibition of factor VIIa by antithrombin III and heparin.
Lawson, J. H., Butenas, S., Ribarik, N., & Mann, K. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53998-3 · Cited by 138 · see citing works
Down-Regulation of Endothelial Expression of Endothelial Cell Protein C Receptor and Thrombomodulin in Coronary Atherosclerosis
Laszik, Z. G., Zhou, X. J., Ferrell, G. L., Silva, F. G., & Esmon, C. T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61753-1 · Cited by 136 · see citing works
Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality
Gu, J.-M., Crawley, J. T. B., Ferrell, G. L., Zhang, F., Li, W., Esmon, N. L., & Esmon, C. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207538200 · Cited by 134 · see citing works
Cell Mediated Events that Control Blood Coagulation and Vascular Injury
Esmon, C. T. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.000245 · Cited by 134 · see citing works
Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells
Yamauchi, T., Umeda, F., Inoguchi, T., & Nawata, H. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91135-2 · Cited by 134 · see citing works
Frequency of protein Z deficiency in patients with ischaemic stroke
Vasse, M., Guegan-Massardier, E., Borg, J. Y., Woimant, F., & Soria, C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04218-5 · Cited by 130 · see citing works
Identification of a thrombin sequence with growth factor activity on macrophages.
Bar‐Shavit, R., Kahn, A. J., Mann, K. G., & Wilner, G. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.976 · Cited by 129 · see citing works
The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18
Kurosawa, S., Esmon, C. T., & Stearns-Kurosawa, D. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4697 · Cited by 127 · see citing works
New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins
Esmon, C. T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021088 · Cited by 127 · see citing works
Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood
Souter, P., Thomas, S., Hubbard, A. R., Poole, S., Römisch, J., & Gray, E. (2001) · Critical Care Medicine · doi:10.1097/00003246-200101000-00027 · Cited by 120 · see citing works
Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice
Hong, S., Scherer, D. C., Singh, N., Mendiratta, S. K., Serizawa, I., Koezuka, Y., & Kaer, L. V. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01304.x · Cited by 119 · see citing works
BINDING OF ACTIVATED PROTEIN C TO A SPECIFIC RECEPTOR ON HUMAN MONONUCLEAR PHAGOCYTES INHIBITS INTRACELLULAR CALCIUM SIGNALING AND MONOCYTE-DEPENDENT PROLIFERATIVE RESPONSES1,2
Hancock, W. W., Grey, S. T., Hau, L., Akalin, E., Orthner, C. L., Sayegh, M. H., & Salem, H. H. (1995) · Transplantation · doi:10.1097/00007890-199560120-00026 · Cited by 117 · see citing works
The Influence of Capsulation and Lipooligosaccharide Structure on Neutrophil Adhesion Molecule Expression and Endothelial Injury by Neisseria meningitidis
Klein, N. J., ISON, C. A., Peakman, M., Levin, M., Hammerschmidt, S., Frosch, M., & Heyderman, R. S. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.1.172 · Cited by 111 · see citing works
Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction
Sandset, P., Warn-Cramer, B. J., Maki, S., & Rapaport, S. (1991) · Blood · doi:10.1182/blood.v78.6.1496.1496 · Cited by 110 · see citing works
Thrombin Induces the Redistribution and Acute Release of Tissue Factor Pathway Inhibitor From Specific Granules Within Human Endothelial Cells in Culture
Lupu, C., Lupu, F., Dennehy, U., Kakkar, V. V., & Scully, M. F. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.2055 · Cited by 107 · see citing works
Thrombin receptor function and cardiovascular disease
Coughlin, S. R. (1994) · Trends in Cardiovascular Medicine · doi:10.1016/1050-1738(94)90013-2 · Cited by 102 · see citing works
Carboxypeptidase R is an inactivator of complement‐derived inflammatory peptides and an inhibitor of fibrinolysis
Campbell, W. D., Okada, N., & Okada, H. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800114.x · Cited by 100 · see citing works
Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy
Wakefield, T. W., Strieter, R. M., Schaub, R., Myers, D. D., Prince, M. R., Wrobleski, S. K., Londy, F. J., Kadell, A. M., Brown, S. L., Henke, P. K., et al. (2000) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(00)90162-9 · Cited by 95 · see citing works
Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase
Pendurthi, U. R., Deoraj, A., & Rao, L. V. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12598 · Cited by 94 · see citing works
Local Overexpression of Thrombomodulin for In Vivo Prevention of Arterial Thrombosis in a Rabbit Model
Waugh, J. M., Yüksel, E., Li, J., Kuo, M. D., Kattash, M., Saxena, R., Geske, R. S., Thung, S. N., Shenaq, S. M., & Woo, S. L. C. (1999) · Circulation Research · doi:10.1161/01.res.84.1.84 · Cited by 91 · see citing works
Structural and Functional Implications of the Intron/Exon Organization of the Human Endothelial Cell Protein C/Activated Protein C Receptor (EPCR) Gene: Comparison With the Structure of CD1/Major Histocompatibility Complex 1 and 2 Domains
Simmonds, R. E., & Lane, D. A. (1999) · Blood · doi:10.1182/blood.v94.2.632 · Cited by 86 · see citing works
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation
Liaw, P. C., FERRELL, G. L., & Esmon, C. T. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00153.x · Cited by 83 · see citing works
Complement Activation in Patients with Sepsis Is in Part Mediated by C‐Reactive Protein
Wolbink, G., Bossink, A. W. J., Groeneveld, A. B. J., de Groot, M. C. M., THIJS, L. G., & Hack, C. E. (1998) · The Journal of Infectious Diseases · doi:10.1086/513803 · Cited by 81 · see citing works
Cytokines, platelet production and hemostasis
Burstein, S. A. (1997) · Platelets · doi:10.1080/09537109709169324 · Cited by 78 · see citing works
Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor‐dependent manner
Shu, F., Kobayashi, H., Fukudome, K., Tsuneyoshi, N., Kimoto, M., & Terao, T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01740-3 · Cited by 73 · see citing works
Antithrombin III in Animal Models of Sepsis and Organ Failure
Dickneite, G. (1998) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-995824 · Cited by 71 · see citing works
Thrombomodulin Overexpression to Limit Neointima Formation
Waugh, J. M., Li-Hawkins, J., Yüksel, E., Kuo, M. D., Cifra, P. N., Hilfiker, P. R., Geske, R. S., Chawla, M., Thomas, J. E., Shenaq, S. M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.3.332 · Cited by 69 · see citing works
Recombinant Tissue Factor Pathway Inhibitor Reduces Lipopolysaccharide-Induced Pulmonary Vascular Injury by Inhibiting Leukocyte Activation
Enkhbaatar, P., Okajima, K., Murakami, K., Uchiba, M., Okabe, H., Okabe, K., & YAMAGUCHI, Y. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.9911018 · Cited by 69 · see citing works
Antithrombin III (AT III) Prevents LPS-Induced Pulmonary Vascular Injury: Novel Biological Activity of AT III
Uchiba, M., & Okajima, K. (1997) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-996140 · Cited by 62 · see citing works
A combination of factor Xa and phosphatidylcholine‐phosphatidylserine vesicles bypasses factor VIII in vivo
Giles, A. R., Mann, K. G., & Nesheim, M. E. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.00483.x-i1 · Cited by 59 · see citing works
A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo
Giles, A. R., Mann, K. G., & Nesheim, M. E. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb02405.x · Cited by 50 · see citing works
Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA: modulation of effects on CD11b and CD14 but not CD25 or CD54 induction.
Grey, S. T., Hau, H., Salem, H., & Hancock, W. W. (1993) · PubMed · Cited by 49 · see citing works
Platelet-Mediated Trigger Mechanisms in the Contact Phase of Blood Coagulation
Walsh, P. (1987) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-1003478 · Cited by 28 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Raczkowski CA, Reichlin M, Esmon CT, Comp PC. Protein Z is a negatively responding acute phase protein. Blood 1987; 70: 393a (abstract #1427).
Glaser CB, Morser J, Clarke JH, Blasko E, McLean K, Kuhn I, Chang RJ, Lin JH, Vilander L, Andrews WH, et al. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. J Clin Invest 1992; 90: 2565-73.
Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L. Lipid antigen presentation in the immune system learned from CD1d knockout mice. Immunol Rev 1999; 169: 31-44.

Sorted by citations

Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548 · see citing works
Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.
Melamed, S., Shirom, A., Toker, S., Berliner, S., & Shapira, I. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.327 · Cited by 943 · see citing works
Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms
Jain, M. K., & Ridker, P. M. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1901 · Cited by 920 · see citing works
The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management
Abou-Ismail, M. Y., Diamond, A., Kapoor, S., Arafah, Y., & Nayak, L. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.06.029 · Cited by 694 · see citing works
A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*
Gando, S., Iba, T., Eguchi, Y., Ohtomo, Y., Okamoto, K., Koseki, K., Mayumi, T., Murata, A., Ikeda, T., Ishikura, H., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000202209.42491.38 · Cited by 647 · see citing works
Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo
Nieuwdorp, M., van Haeften, T. W., Gouverneur, M., Mooij, H. L., van Lieshout, M. H. P., Levi, M. M., Meijers, J. C. M., Holleman, F., Hoekstra, J. B. L., Vink, H., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1103 · Cited by 621 · see citing works
Disseminated intravascular coagulation
Gando, S., Levi, M. M., & Toh, C. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.37 · Cited by 598 · see citing works
The multifaceted role of fibrinogen in tissue injury and inflammation
Luyendyk, J. P., Schoenecker, J. G., & Flick, M. J. (2018) · Blood · doi:10.1182/blood-2018-07-818211 · Cited by 560 · see citing works
The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair
Vollmar, B., & Menger, M. D. (2009) · Physiological Reviews · doi:10.1152/physrev.00027.2008 · Cited by 505 · see citing works
Obesity: A Chronic Low-Grade Inflammation and Its Markers
Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022) · Cureus · doi:10.7759/cureus.22711 · Cited by 531 · see citing works
Interplay between platelets and coagulation
Sang, Y., Roest, M., de Laat, B., de Groot, P. G., & Huskens, D. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100733 · Cited by 406 · see citing works
Mechanisms of Venous Thrombosis and Resolution
Wakefield, T. W., Myers, D. D., & Henke, P. K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162289 · Cited by 387 · see citing works
Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function
Lin, Z., Kumar, A., SenBanerjee, S., Staniszewski, K. E., Parmar, K. M., Vaughan, D. E., Gimbrone, M. A., Balasubramanian, V., García‐Cardeña, G., & Jain, M. K. (2005) · Circulation Research · doi:10.1161/01.res.0000159707.05637.a1 · Cited by 385 · see citing works
Thrombomodulin-Protein C-EPCR System
de Wouwer, M. V., Collen, D., & Conway, E. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000134298.25489.92 · Cited by 370 · see citing works
Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells
SenBanerjee, S., Mir, S. S., Lin, Z., Hamik, A., Atkins, G. B., Das, H., Banerjee, P., Kumar, A., & Jain, M. K. (2005) · Circulation · doi:10.1161/circulationaha.104.525774 · Cited by 348 · see citing works
Serpins in thrombosis, hemostasis and fibrinolysis
Rau, J. C., Beaulieu, L. M., Huntington, J. A., & Church, F. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02516.x · Cited by 349 · see citing works
Blood Coagulation: Hemostasis and Thrombin Regulation
Tanaka, K. A., Key, N. S., & Levy, J. H. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31819bcc9c · Cited by 343 · see citing works
Thrombin
Di, E. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.01.001 · Cited by 335 · see citing works
Sepsis, thrombosis and organ dysfunction
Semeraro, N., Ammollo, C. T., Semeraro, F., & Colucci, M. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.10.013 · Cited by 331 · see citing works
Air particulate matter and cardiovascular disease: A narrative review
Martinelli, N., Olivieri, O., & Girelli, D. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.04.001 · Cited by 315 · see citing works
The endothelial glycocalyx: a potential barrier between health and vascular disease
Nieuwdorp, M., Meuwese, M. C., Vink, H., Hoekstra, J. B. L., Kastelein, J. J. P., & Stroes, E. S. G. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000181325.08926.9c · Cited by 311 · see citing works
Microvascular thrombosis and multiple organ dysfunction syndrome
Gando, S. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c9e31d · Cited by 308 · see citing works
Efficacy and Safety of Anticoagulant Treatment in Acute Cardioembolic Stroke: A Meta-Analysis of Randomized Controlled Trials
Paciaroni, M., Agnelli, G., Micheli, S., & Caso, V. (2007) · Stroke · doi:10.1161/01.str.0000254600.92975.1f · Cited by 307 · see citing works
Estrogen and thrombosis: a bench to bedside review
Abou-Ismail, M. Y., Citla Sridhar, D., & Nayak, L. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.008 · Cited by 261 · see citing works
Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy
Moik, F., Chan, W.-S. E., Wiedemann, S., Höeller, C., Tuchmann, F., Aretin, M., Fuereder, T., Zöchbauer‐Müller, S., Preusser, M., Pabinger, I., et al. (2020) · Blood · doi:10.1182/blood.2020007878 · Cited by 235 · see citing works
Inflammation and Stroke Risk: A New Target for Prevention
Kelly, P. J., Lemmens, R., & Tsivgoulis, G. K. (2021) · Stroke · doi:10.1161/strokeaha.121.034388 · Cited by 217 · see citing works
Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease
Ha, C. Y., Magowan, S., Accortt, N., Chen, J., & Stone, C. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.81 · Cited by 231 · see citing works
Challenges and emerging technologies in the immunoisolation of cells and tissues.
Wilson, J. T., & Chaikof, E. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.034 · Cited by 197 · see citing works
Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents
Lordan, R., Τσούπρας, Α., & Zabetakis, I. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100694 · Cited by 179 · see citing works
Inflammation and hemostasis
Margetić, S. (2012) · Biochemia Medica · doi:10.11613/bm.2012.006 · Cited by 179 · see citing works
Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome
Mertens, I. L., Verrijken, A., Michiels, J. J., van der Planken, M., Ruige, J. B., & Gaal, L. F. V. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803189 · Cited by 176 · see citing works
Trauma, Shock, and Disseminated Intravascular Coagulation
Gando, S., Sawamura, A., & Hayakawa, M. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e31821221b1 · Cited by 170 · see citing works
Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease
Zhang, Z., Dalan, R., Hu, Z., Wang, J., Chew, N., Poh, K. K., Tan, R., Soong, T. W., Dai, Y., Ye, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202169 · Cited by 174 · see citing works
Coagulopathy of Acute Sepsis
Ammollo, C. T., Semeraro, F., Colucci, M., & Semeraro, N. (2015) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0035-1556730 · Cited by 167 · see citing works
SEPSIS-ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION AND THROMBOEMBOLIC DISEASE
Semeraro, N., Ammollo, C. T., Semeraro, F., & Colucci, M. (2010) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2010.024 · Cited by 166 · see citing works
Tumor necrosis factor-α-induced TRPC1 expression amplifies store-operated Ca2+influx and endothelial permeability
Paria, B. C., Vogel, S. M., Ahmmed, G. U., Alamgir, S., Shroff, J., Malik, A. B., & Tiruppathì, C. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00240.2004 · Cited by 157 · see citing works
Inflammation and haemostasis.
Margetić, S. (2012) · PubMed Central · Cited by 155 · see citing works
Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction
Timmer, J. R., Ottervanger, J. P., de Boer, M., Dambrink, J. E., Hoorntje, J. C. A., Gosselink, A. T. M., Suryapranata, H., Zijlstra, F., & Hof, A. W. J. V. ’. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.050 · Cited by 150 · see citing works
Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease
Picco, M. F. (2009) · Yearbook of Gastroenterology · doi:10.1016/s0739-5930(09)79360-2 · Cited by 147 · see citing works
Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock
Gando, S., & Otomo, Y. (2015) · Critical Care · doi:10.1186/s13054-015-0735-x · Cited by 144 · see citing works
Platelets as Mediators of Neuroinflammation and Thrombosis
Rawish, E., Nording, H., Münte, T., & Langer, H. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.548631 · Cited by 143 · see citing works
Inflammatory bowel disease
Yoshida, H., & Granger, N. D. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20896 · Cited by 141 · see citing works
Polyphosphate elicits pro‐inflammatory responses that are counteracted by activated protein C in both cellular and animal models
Bae, J.-E., Lee, W., & Rezaie, A. R. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04671.x · Cited by 138 · see citing works
Anticoagulants in heart disease: current status and perspectives
Caterina, R. D., Husted, S., Wallentin, L. C., Agnelli, G., Bachmann, F., Baigent, C., Jespersen, J., Kristensen, S., Montalescot, G., Siegbahn, A. G., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl492 · Cited by 137 · see citing works
Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization
Vanthienen, J., Fledderus, J. O., Dekker, R. J., Rohlena, J., VANIJZENDOORN, G., Kootstra, N. A., Pannekoek, H., & Horrevoets, A. J. G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.07.008 · Cited by 134 · see citing works
Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.
Contreras, J., Eckstein, C., Smyth, C. A., Bilbao, G., Vilatoba, M., Ringland, S., Young, C., Thompson, J., Fernández, J. A., Griffin, J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2804 · Cited by 138 · see citing works
Targeting drug delivery in the vascular system: Focus on endothelium
Glassman, P. M., Myerson, J. W., Ferguson, L. T., Kiseleva, R. Y., Shuvaev, V. V., Brenner, J. S., & Muzykantov, V. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.013 · Cited by 133 · see citing works
Blood coagulation-dependent inflammation. Coagulation-dependent inflammation and inflammation-dependent thrombosis
Strukova, S. M. (2006) · Frontiers in bioscience · doi:10.2741/1780 · Cited by 133 · see citing works
Ovarian cancer, the coagulation pathway, and inflammation
Wang, X., Wang, E., Kavanagh, J. J., & Freedman, R. S. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-25 · Cited by 132 · see citing works
The coagulopathy and thrombotic risk associated with L-Asparaginase treatment in adults with acute lymphoblastic leukaemia
Truelove, E., Fielding, A. K., & Hunt, B. J. (2012) · Leukemia · doi:10.1038/leu.2012.290 · Cited by 130 · see citing works
Elevated Levels of High-Sensitivity C-Reactive Protein and Serum Amyloid-A Late After Kawasaki Disease
Mitani, Y., Sawada, H., Hayakawa, H., Aoki, K., Ohashi, H., Matsumura, M., Kuroe, K., Shimpo, H., Nakano, M., & Komada, Y. (2004) · Circulation · doi:10.1161/01.cir.0000151311.38708.29 · Cited by 128 · see citing works
NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis
Qiao, J., Wu, X., Luo, Q., Wei, G., Xu, M., Wu, Y., Liu, Y., Li, X., Zi, J., Ju, W., et al. (2018) · Haematologica · doi:10.3324/haematol.2018.191700 · Cited by 127 · see citing works
Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease
Scaldaferri, F., Sans, M., Vetrano, S., Graziani, C., CRISTOFARO, R. D., Gerlitz, B., Repici, A., Arena, V., Malesci, A., Panés, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31027 · Cited by 127 · see citing works
Platelet-derived microvesicles transfer tissue factor to monocytes but not to neutrophils
Lösche, W., Scholz, T., Temmler, U., Oberle, V., & Claus, R. A. (2004) · Platelets · doi:10.1080/09537100310001649885 · Cited by 116 · see citing works
The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?
Altman, R., Luciardi, H. L., Muntaner, J. A., & Herrera, R. N. (2004) · Thrombosis Journal · doi:10.1186/1477-9560-2-1 · Cited by 115 · see citing works
Blood coagulation and the risk of atherothrombosis: a complex relationship.
Spronk, H. M. H., van der Voort, D., & Cate, H. T. (2004) · Thrombosis Journal · doi:10.1186/1477-9560-2-12 · Cited by 116 · see citing works
Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B
Sohn, R. H., Deming, C., Johns, D. C., Champion, H. C., Bian, C., Gardner, K. L., & Rade, J. J. (2005) · Blood · doi:10.1182/blood-2004-03-0928 · Cited by 110 · see citing works
Cerebral Microvascular Responses to Hypercholesterolemia
Ishikawa, M., Stokes, K. Y., Zhang, J. H., Nanda, A., & Granger, D. N. (2003) · Circulation Research · doi:10.1161/01.res.0000111524.05779.60 · Cited by 109 · see citing works
Fibrin(ogen)-α M β 2 Interactions Regulate Leukocyte Function and Innate Immunity In Vivo
Flick, M. J., Du, X., & Degen, J. L. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901104 · Cited by 107 · see citing works
Structure and functions of the endothelial cell protein C receptor
Esmon, C. T. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000126128.64614.81 · Cited by 107 · see citing works
Genetic and Plasma Markers of Venous Thromboembolism in Patients with High Grade Glioma
Sciacca, F. L., Ciusani, E., Silvani, A., Corsini, E., Frigerio, S., Pogliani, S., Parati, E. A., Croci, D., Boiardi, A., & Salmaggi, A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0198 · Cited by 102 · see citing works
Advanced drug delivery systems for antithrombotic agents
Greineder, C. F., Howard, M. D., Carnemolla, R., Cines, D. B., & Muzykantov, V. R. (2013) · Blood · doi:10.1182/blood-2013-03-453498 · Cited by 97 · see citing works
The influence of clinical characteristics, laboratory and inflammatory markers on ‘high on-treatment platelet reactivity’ as measured with different platelet function tests
Elsenberg, E. H. A. M., van de Wal, R. M. A., Zomer, C. A., Bouman, H. J., Verheugt, F. W. A., ten Berg, J. M., Hackeng, C. M., & van Werkum, J. W. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-05-0285 · Cited by 97 · see citing works
Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy
Yao, M., Ma, J., Wu, D.-W., Fang, C., Wang, Z.-L., Guo, T., & Mo, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1198952 · Cited by 89 · see citing works
Therapy Insight: vascular complications in patients with inflammatory bowel disease
Κoutroubakis, I. E. (2005) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0190 · Cited by 97 · see citing works
microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis
Santulli, G. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22380-3_4 · Cited by 96 · see citing works
Heart failure and anti tumor necrosis factor-alpha in systemic chronic inflammatory diseases
Sinagra, E., Perricone, G., Romano, C., & Cottone, M. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.12.015 · Cited by 95 · see citing works
Protease-activated Receptor-1 Activation of Endothelial Cells Induces Protein Kinase Cα-dependent Phosphorylation of Syntaxin 4 and Munc18c
Fu, J., Naren, A. P., Gao, X., Ahmmed, G. U., & Malik, A. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410044200 · Cited by 95 · see citing works
Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post‐thrombotic syndrome
Rabinovich, A., Cohen, J. M., Cushman, M., Wells, P. S., Rodger, M. A., Kovacs, M. J., Anderson, D. R., Tagalakis, V., Lazo‐Langner, A., Solymoss, S., et al. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12814 · Cited by 93 · see citing works
Coagulation, Inflammation, and the Risk of Neonatal White Matter Damage
Leviton, A., & Dammann, O. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000121197.24154.82 · Cited by 93 · see citing works
C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke: An Individual Participant Data Meta-Analysis
McCabe, J. J., Walsh, C., Gorey, S., Harris, K., Hervella, P., Iglesias‐Rey, R., Jern, C., Li, L., Miyamoto, N., Montaner, J., et al. (2023) · Stroke · doi:10.1161/strokeaha.122.040529 · Cited by 92 · see citing works
Expression of complement components and inhibitors on platelet microparticles
Yin, W., Ghebrehiwet, B., & Peerschke, E. I. B. (2008) · Platelets · doi:10.1080/09537100701777311 · Cited by 92 · see citing works
Thrombophilia and Arteriovenous Fistula Survival in ESRD
Salmela, B., Hartman, J., Peltonen, S., Albäck, A., & Lassila, R. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03860412 · Cited by 88 · see citing works
Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke
Griffin, J. H., Zloković, B. V., & Fernández, J. A. (2002) · Seminars in Hematology · doi:10.1053/shem.2002.34093 · Cited by 84 · see citing works
The roles of cellular and molecular components of a hematoma at early stage of bone healing
Shiu, H. T., Leung, P., & Ko, C. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2622 · Cited by 83 · see citing works
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation
Vetrano, S., Ploplis, V. A., Sala, E., Sandoval-Cooper, M. J., Donahue, D. L., Correale, C., Arena, V., Spinelli, A., Repici, A., Malesci, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107140108 · Cited by 83 · see citing works
Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability
de Waal, G. M., de Villiers, W. J. S., Forgan, T., Roberts, T. J., & Pretorius, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-65324-2 · Cited by 82 · see citing works
Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin
Starr, M. E., Ueda, J., Takahashi, H., Weiler-Guettler, H., Esmon, C. T., Evers, B. M., & Saitō, H. (2010) · Blood · doi:10.1182/blood-2009-10-246678 · Cited by 82 · see citing works
Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis.
Ramacciotti, E., Hawley, A. E., Farris, D. M., Ballard, N., Wrobleski, S. K., Myers, D. D., Henke, P. K., & Wakefield, T. W. (2009) · PubMed · Cited by 81 · see citing works
SIRS-ASSOCIATED COAGULOPATHY AND ORGAN DYSFUNCTION IN CRITICALLY ILL PATIENTS WITH THROMBOCYTOPENIA
Ogura, H., Gando, S., Iba, T., Eguchi, Y., Ohtomo, Y., Okamoto, K., Koseki, K., Mayumi, T., Murata, A., Ikeda, T., et al. (2007) · Shock · doi:10.1097/shk.0b013e31804f7844 · Cited by 79 · see citing works
Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability
Maestri, E., Pavlićević, M., Montorsi, M., & Marmiroli, N. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12402 · Cited by 78 · see citing works
Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis
Hawley, A. E., Farris, D. M., Ballard, N., Wrobleski, S. K., Myers, D. D., Henke, P. K., Wakefield, T. W., & Ramacciotti, E. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-09-0620 · Cited by 78 · see citing works
C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S–independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies
Buil, A., Trégouët, D., Souto, J. C., Saut, N., Germain, M., Rotival, M., Tiret, L., Cambien, F., Lathrop, M. G., Zeller, T., et al. (2010) · Blood · doi:10.1182/blood-2010-01-263038 · Cited by 76 · see citing works
Biomaterials Regulating Bone Hematoma for Osteogenesis
Yang, Y., & Xiao, Y. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000726 · Cited by 75 · see citing works
Hematologic concerns in extracorporeal membrane oxygenation
Sniderman, J. D. S., Monagle, P., Annich, G. M., & MacLaren, G. (2020) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12346 · Cited by 73 · see citing works
From normal to pathological hemostasis
Lasne, D., Jude, B., & Susen, S. (2006) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03022247 · Cited by 73 · see citing works
Practical Hemostasis and Thrombosis
(2005) · Wiley eBooks · doi:10.1002/9780470988633 · Cited by 73 · see citing works
PLATELET-LEUKOCYTE INTERACTIONS : MULTIPLE LINKS BETWEEN INFLAMMATION , BLOOD COAGULATION AND VASCULAR RISK
Cerletti, C., de Gaetano, G., & Lorenzet, R. (2010) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2010.023 · Cited by 72 · see citing works
Thrombolytic Agents: Nanocarriers in Controlled Release
Hassanpour, S., Kim, H., Saadati, A., Tebon, P. J., Xue, C., van den Dolder, F. W., Thakor, J., Baradaran, B., Mosafer, J., Baghbanzadeh, A., et al. (2020) · Small · doi:10.1002/smll.202001647 · Cited by 70 · see citing works
Endometriosis and cardiovascular disease
Marchandot, B., Curtiaud, A., Matsushita, K., Trimaille, A., Host, A., Faller, É., Garbin, O., Akladios, C. Y., Jesel, L., & Morel, O. (2022) · European Heart Journal Open · doi:10.1093/ehjopen/oeac001 · Cited by 72 · see citing works
Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy
Musumba, C. O. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12490 · Cited by 69 · see citing works
Pathological Findings in Dogs with Fatal Heatstroke
Bruchim, Y., Loeb, E., Saragusty, J., & Aroch, I. (2008) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2008.07.011 · Cited by 69 · see citing works
Class prediction models of thrombocytosis using genetic biomarkers
Gnatenko, D. V., Zhu, W., Xu, X., Samuel, E. T., Monaghan, M., Zarrabi, M. H., Kim, C., Dhundale, A., & Bahou, W. F. (2009) · Blood · doi:10.1182/blood-2009-05-224477 · Cited by 69 · see citing works
Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2
Pircher, J., Merkle, M., Wörnle, M., Ribeiro, A., Czermak, T., Stampnik, Y., Mannell, H., Niemeyer, M., Vielhauer, V., & Krötz, F. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4064 · Cited by 69 · see citing works
Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis
Zaitsev, S. V., Kowalska, M. A., Neyman, M., Carnemolla, R., Tliba, S., Ding, B., Stonestrom, A. J., Spitzer, D., Atkinson, J. P., Poncz, M., et al. (2012) · Blood · doi:10.1182/blood-2011-12-398149 · Cited by 68 · see citing works
Further evidence for sustained systemic inflammation in xenograft recipients ( SIXR )
Iwase, H., Ekser, B., Zhou, H., Liu, H., Satyananda, V., Humar, R., Humar, P., Hara, H., Long, C. E., Bhama, J. K., et al. (2015) · Xenotransplantation · doi:10.1111/xen.12182 · Cited by 68 · see citing works
Ambient air pollution and cardiovascular diseases: From bench to bedside
Vidale, S., & Campana, C. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318766638 · Cited by 67 · see citing works
Stored red blood cell supernatant facilitates thrombin generation
Sweeney, J. D., KOUTTAB, N. M., & Kurtis, J. D. (2009) · Transfusion · doi:10.1111/j.1537-2995.2009.02196.x · Cited by 66 · see citing works
Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?
Poredoš, P., Spirkoska, A., Ručigaj, T. P., Fareed, J., & Jezovnik, M. K. (2015) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2015.04.031 · Cited by 65 · see citing works
The Role of Microvascular Thrombosis in Sepsis
Dixon, B. (2004) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0403200502 · Cited by 63 · see citing works

Authors: Esmon, C. T.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Esmon, C.T.
Venue: Journal of Thrombosis and Haemostasis
Publisher: Elsevier BV
Published: 2003-07
Volume: 1
Issue: 7
Pages: 1343-1348
ISSN: 1538-7836 (ISSN-L)
DOI: 10.1046/j.1538-7836.2003.00261.x
OpenAlex: W2024773717
Cited by: 442
References: 75
Citations by year: 2026: 17 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 16 · 2021: 22 · 2020: 29 · 2019: 15 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 15 · 2014: 5 · 2013: 18 · 2012: 23
FWCI: 3.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7104 d)
Locations: Journal of Thrombosis and Haemostasis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords: systemic inflammation, thrombosis, procoagulant factors, natural anticoagulants, fibrinolysis, platelet reactivity, coagulation, inflammatory mediators
MeSH terms: Animals, Anticoagulants, Antithrombins, Endothelium, Vascular, Humans, Inflammation, Lipoproteins, Models, Biological, Protein C, Thrombin, Thrombosis, Down-Regulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and thrombosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks