Inflammation and Immunity in Diseases of the Arterial Tree: Players and Layers
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The hypothesis that immunity and inflammation participate in the pathogenesis of vascular diseases has now gained widespread recognition and stimulated work around the globe. Broadening knowledge has extended the recognition of the role of immune and inflammatory mechanisms to all of the layers of the artery, to all levels of the arterial tree, and implicated virtually all arms, cellular players, and effector molecules and pathways involved in these crucial host defenses, that turn against us in disease. We provide here a guide to a compendium series of articles that aimed to look forward and broaden the traditional focus of immunopathogenesis of arterial disease, with the goal of integrating the players and the layers involved. Although the field has advanced remarkably, much remains to be done, and this commentary also aims to highlight some of the gaps that future research should strive to close on the participation of inflammation and immunity in arterial diseases.
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Important ramifications of low-grade inflammation include insulin resistance, endothelial dysfunction, atherosclerosis, neuroinflammation, and immunodeficiency due to impaired dendritic cell, T, and B cell functions, which can promote failure of tumor and pathogen defense.
“Important ramifications of low-grade inflammation are insulin resistance, endothelial dysfunction, atherosclerosis, and neuroinflammation (109, 244, 336, 485, 572), as well as immunodeficiency due to impaired DC, T, and B cell functions (80, 199, 422), which in turn can promote failure of tumor and pathogen defense (123, 426) (reviewed in Ref. 198).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [336]
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- Authors
- Libby, P., & Hansson, G. K.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Libby, Peter
- Venue
- Circulation Research
- Published
- 2015-01-16
- Volume
- 116
- Issue
- 2
- Pages
- 307-311
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4299915
- OpenAlex
- W1985554823
- Cited by
- 372
- References
- 23
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 20 · 2023: 16 · 2022: 27 · 2021: 30 · 2020: 27 · 2019: 44 · 2018: 49 · 2017: 51 · 2016: 38 · 2015: 21 · 2014: 2
- FWCI
- 26.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- European Commission
- Fondation Leducq
- Hjärt-Lungfonden
- Stockholms Läns Landsting
- Vetenskapsrådet
- National Institutes of Health
- National Heart, Lung, and Blood Institute (U01HL080731, HL080731, HL080472, R01HL080472)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- inflammation, immunity, arterial disease, immunopathogenesis, vascular disease pathogenesis, immune cells, effector molecules
- MeSH terms
- Animals, Arteries, Humans, Immunity, Innate, Inflammation, Vascular Diseases
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