The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
More than an anticoagulant: Do heparins have direct anti-inflammatory effects?
Abstract
Summary: The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases. This review focuses on the inflammatory pathophysiology that underlies the development of thrombosis and the putative effects of heparin on these pathways. We present evidence supporting the use of heparin for other indications, including autoimmune disease, malignancy, and disseminated intravascular coagulation. These considerations highlight the need for further research to elucidate the mechanisms of the possible pleiotropic effects of the heparins, with a view to advancing treatments based upon heparin derivatives.
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Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614
Neutrophil extracellular traps: Is immunity the second function of chromatin?
Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021
Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799
Self-citationWang, L., Brown, J. R., Varki, A., & Esko, J. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214996 · Cited by 288
Cited by
ISTH interim guidance on recognition and management of coagulopathy in COVID‐19
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Thrombotic complications of COVID-19
Avila, J., Long, B., Holladay, D., & Gottlieb, M. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.09.065 · Cited by 143
The looming storm: Blood and cytokines in COVID-19
Kaur, S., Bansal, R., Kollimuttathuillam, S., Gowda, A. M., Singh, B., Mehta, D., & Maroules, M. (2021) · Blood Reviews · doi:10.1016/j.blre.2020.100743 · Cited by 113
Metadata
- Authors
- Poterucha, T. J., Libby, P., & Goldhaber, S. Z.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2017
- Volume
- 117
- Issue
- 03
- Pages
- 437-444
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2567022534
- Cited by
- 199
- References
- 5
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
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