The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Platelets, inflammation and tissue regeneration
Abstract
Summary: Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, they store and release a wide range of biologically active substances including the panoply of growth factors, chemokines and cytokines released from α-granules. Membrane budding gives rise to microparticles (MPs), another active participant within the blood stream. Platelets are essential for the innate immune response and combat infection (viruses, bacteria, micro-organisms). They help maintain and modulate inflammation and are a major source of pro-inflammatory molecules (e.g. P-selectin, tissue factor, CD40L, metalloproteinases). As well as promoting coagulation, they are active in fibrinolysis; wound healing, angiogenesis and bone formation as well as in maternal tissue and foetal vascular remodelling. Activated platelets and MPs intervene in the propagation of major diseases. They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth. They participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth. The above mentioned roles of platelets are now discussed.
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Cites
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Membrane Fusion: Grappling with SNARE and SM Proteins
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Matrix metalloproteinases as modulators of inflammation and innate immunity
Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
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Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
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Novel functions of TIMPs in cell signaling
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Cited by
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 474
Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
Deppermann, C., Cherpokova, D., Nurden, P., Schulz, J.-N., Thielmann, I., Kraft, P., Vögtle, T., Kleinschnitz, C., Dütting, S., Krohne, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69210 · Cited by 200
Self-citationBlood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Dewitte, A., Lepreux, S., Villeneuve, J., Rigothier, C., Combe, C., Ouattara, A., & Ripoche, J. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0337-7 · Cited by 194
Doni, A., Musso, T., Morone, D., Bastone, A., Zambelli, V., Sironi, M., Castagnoli, C., Cambieri, I., Stravalaci, M., Pasqualini, F., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141268 · Cited by 151
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
Fuentes, E., Caballero, J., Alarcón, M., Rojas, A., & Palomo, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090699 · Cited by 115
Metadata
- Authors
- Nurden, A.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2011
- Volume
- 105
- Issue
- S 06
- Pages
- S13-S33
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2080900526
- Cited by
- 791
- References
- 8
- FWCI
- 37.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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