Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
Open accessAbstract
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, α-granules, release proteins that participate in thrombus formation and hemostasis. Proteins stored in α-granules are also thought to play a role in inflammation and wound healing, but their functional significance in vivo is unknown. Mutations in NBEAL2 have been linked to gray platelet syndrome (GPS), a rare bleeding disorder characterized by macrothrombocytopenia, with platelets lacking α-granules. Here we show that Nbeal2-knockout mice display the characteristics of human GPS, with defective α-granule biogenesis in MKs and their absence from platelets. Nbeal2 deficiency did not affect MK differentiation and proplatelet formation in vitro or platelet life span in vivo. Nbeal2-deficient platelets displayed impaired adhesion, aggregation, and coagulant activity ex vivo that translated into defective arterial thrombus formation and protection from thrombo-inflammatory brain infarction following focal cerebral ischemia. In a model of excisional skin wound repair, Nbeal2-deficient mice exhibited impaired development of functional granulation tissue due to severely reduced differentiation of myofibroblasts in the absence of α-granule secretion. This study demonstrates that platelet α-granule constituents are critically required not only for hemostasis but also thrombosis, acute thrombo-inflammatory disease states, and tissue reconstitution after injury.
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The relevance of platelets and their products for successful tissue reconstitution is reflected in the clinical use of platelet-rich plasma to promote healing and in impaired healing in preclinical models recapitulating platelet disorders.
“The relevance of platelets and their products for successful tissue reconstitution is reflected in the clinical use of platelet-rich plasma to promote healing (22) and impaired healing in preclinical models recapitulating platelet disorders (23).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [23]
Inflammatory cell recruitment and activation at wound sites are driven by multiple signals, including factors released by degranulating platelets and by DAMPs and PAMPs from damaged cells and microbes.
“Inflammatory cell recruitment and activation are a consequence of many signals that occur at the wound site. Some of the earliest signals include factors released by degranulating platelets (23) and by damage- and pathogen-associated molecular patterns (DAMPs and PAMPs, respectively) where cells are damaged and microbes gain access (107).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [23]
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Self-citation
- Authors
- Deppermann, C., Cherpokova, D., Nurden, P., Schulz, J.-N., Thielmann, I., Kraft, P., Vögtle, T., Kleinschnitz, C., Dütting, S., Krohne, G., Eming, S. A., Nurden, A. T., Eckes, B., Stoll, G., Stegner, D., & Nieswandt, B.
- Affiliations
- University of Würzburg (DE)
- University of Cologne (DE)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2013-07-01
- Volume
- 123
- Issue
- 8
- Pages
- 3331-3342
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4011026
- OpenAlex
- W1982213737
- Cited by
- 200
- References
- 66
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 6 · 2021: 16 · 2020: 15 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 22 · 2015: 19 · 2014: 22 · 2013: 5
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB829, SFB 688)
- Julius-Maximilians-Universität Würzburg
- Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- gray platelet syndrome, NBEAL2, alpha-granules, megakaryocytes, thromboinflammation, arterial thrombus formation, focal cerebral ischemia, cerebral infarction, platelet adhesion and aggregation, coagulant activity, hemostasis, wound healing, myofibroblast differentiation, granulation tissue, bleeding disorders
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