The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice
Open accessAbstract
Objective— We sought to define the temporal characteristics of angiotensin II (AngII)-induced abdominal aortic aneurysms (AAAs) and to provide mechanistic insight into the development of this vascular pathology in apolipoprotein E-deficient (apoE-/-) mice. Methods and Results— Male apoE-/- mice were infused with AngII for 1 to 56 days. Suprarenal arteries were sequentially sectioned, and cellular features were defined by histologic and immunocytochemical techniques. The initial identified event was medial accumulation of macrophages in regions of elastin degradation. Subsequent medial dissection was associated with luminal dilation and thrombus formation. Thrombi were usually constrained by adventitial tissue, although ≈10% of mice died due to rupture. Thrombi led to profound inflammation that was characterized by infiltration of macrophages and T and B lymphocytes. Remodeling of the tissues was associated with regeneration of elastin fibers and reendothelialization of the dilated luminal surface. Aneurysmal tissue underwent profound neovascularization. Atherosclerotic lesions were only detected after development of the aneurysms. Conclusions— The initial event in AngII-induced AAA is a focal dissection in the suprarenal region. The progression of AAA precedes the development of overt atherosclerotic lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice
Daugherty, A., Manning, M. W., & Cassis, L. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7818 · Cited by 1,368
Self-citationFaggiotto, A., Ross, R., & Harker, L. (1984) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.4.4.323 · Cited by 984
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
Longo, G. M., Xiong, W., Greiner, T. C., Zhao, Y., Fiotti, N., & Baxter, B. T. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215334 · Cited by 877
Pyo, R., Lee, J. K., Shipley, J. M., Curci, J. A., Mao, D., Ziporin, S. J., Ennis, T. L., Shapiro, S. D., Senior, R. M., & Thompson, R. W. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8931 · Cited by 830
Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms
Golub, L. M., Lee, H.-M., Ryan, M. E., Giannobile, W. V., Payne, J., & Sorsa, T. (1998) · Advances in Dental Research · doi:10.1177/08959374980120010501 · Cited by 687
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaître, V., Tipping, P., Drew, A., Eeckhout, Y., Shapiro, S., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 661
Kuhlencordt, P. J., Gyurko, R., Han, F., Scherrer-Crosbie, M., Aretz, T. H., Hajjar, R., Picard, M. H., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc2901.091399 · Cited by 630
Vascular inflammation and the renin-angiotensin system
Brasier, A. R., Recinos, A., & Eledrisi, M. S. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000021412.56621.a2 · Cited by 586
Cited by
Monocytes and macrophages in abdominal aortic aneurysm
Raffort, J., Lareyre, F., Clément, M., Hassen-Khodja, R., Chinetti, G., & Mallat, Z. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.52 · Cited by 432
Wang, Y., Ait-Oufella, H., Herbin, O., Bonnin, P., Ramkhelawon, B., Taleb, S., Huang, J., Offenstadt, G., Combadière, C., Rénia, L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38136 · Cited by 414
Clarke, M. C. H., Littlewood, T. D., Figg, N., Maguire, J. J., Davenport, A. P., Goddard, M., & Bennett, M. R. (2008) · Circulation Research · doi:10.1161/circresaha.108.175976 · Cited by 396
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Jana, S., Hu, M., Shen, M., & Kassiri, Z. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0286-3 · Cited by 226
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis
Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1501132 · Cited by 149
Metadata
- Authors
- Saraff, K., Babamusta, F., Cassis, L. A., & Daugherty, A.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-09
- Volume
- 23
- Issue
- 9
- Pages
- 1621-1626
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2159351650
- Cited by
- 428
- References
- 40
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice. https://app.cochat.ai/papers/10.1161/01.atv.0000085631.76095.64
- The paper
- Saraff, K., Babamusta, F., Cassis, L. A., & Daugherty, A. (2003). Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000085631.76095.64
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
