The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Formation and Metabolism of Prebeta-Migrating, Lipid-Poor Apolipoprotein A-I
Open accessAbstract
The preferred extracellular acceptor of cell phospholipids and unesterified cholesterol in the process mediated by the ATP-binding cassette A1 (ABCA1) transporter is a monomolecular, prebeta-migrating, lipid-poor or lipid-free form of apolipoprotein (apo) A-I. This monomolecular form of apoA-I is quite distinct from the prebeta-migrating, discoidal high-density lipoprotein (HDL) that contains two or three molecules of apoA-I per particle and which are present as minor components of the HDL fraction in human plasma. The mechanism of the ABCA1-mediated efflux of phospholipid and cholesterol from cells has been studied extensively. In contrast, much less attention has been given to the origin and subsequent metabolism of the acceptor lipid-free/lipid-poor apoA-I. There is a substantial body of evidence from studies conducted in vitro that a monomolecular, lipid-free/lipid-poor form of apoA-I dissociates from HDL during the remodeling of HDLs by plasma factors such as cholesteryl ester transfer protein, hepatic lipase, and phospholipid transfer protein. The rate at which apoA-I dissociates from HDL is influenced by the phospholipid composition of the particles and by the presence of apoA-II. This review describes current knowledge regarding the formation, metabolism, and regulation of monomolecular, lipid-free/lipid-poor apoA-I in plasma.
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Cited by
Cholesterol Efflux and Atheroprotection: Advancing the Concept of Reverse Cholesterol Transport
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Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice
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High-density lipoprotein heterogeneity and function in reverse cholesterol transport
Rothblat, G. H., & Phillips, M. C. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328338472d · Cited by 340
Metadata
- Authors
- Rye, K.-A., & Barter, P. J.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-03
- Volume
- 24
- Issue
- 3
- Pages
- 421-428
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2155406689
- Cited by
- 309
- References
- 66
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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