The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models
Abstract
Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and dyslipidemia, insulin resistance, and type 2 diabetes mellitus. Recently, attention has been focused on the excessive accumulation of triglycerides (TG) in the liver as part of this syndrome. In this review, important principles of the pathophysiological involvement of the liver in the metabolic syndrome obtained in rodent models are summarized. We focus on non-alcoholic causes of steatosis, because the animal experiments we refer to did not include alcohol as an experimental condition. In general, there is continuous cycling and redistribution of non-oxidized fatty acids between different organs. The amount of TG in an intrinsically normal liver is not fixed but can readily be increased by nutritional, metabolic, and endocrine interactions involving TG/free fatty acid (FFA) partitioning and TG/FFA metabolism. Several lines of evidence indicate that hepatic TG accumulation is also a causative factor involved in hepatic insulin resistance. Complex interactions between endocrine, metabolic, and transcriptional pathways are involved in TG-induced hepatic insulin resistance. Therefore, the liver participates passively and actively in the metabolic derangements of the metabolic syndrome. We speculate that similar mechanisms may also be involved in human pathophysiology.
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“The metabolic syndrome is also an independent indicator for chronic kidney disease [636] and may be related to liver steatosis [637].”
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“Steatosis has often been associated with hepatic IR in the context of obesity [43].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [43]
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Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
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Research works printed but not linked: 3
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- 10.1210/jcem.87.7.8638 · DOI · Paper page
- 2001, Int J Obes Relat Metab Disord, 25, S35
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Neuschwander‐Tetri, B. A. (2010) · Hepatology · doi:10.1002/hep.23719 · Cited by 1,077
Triglyceride Metabolism in the Liver
Alves‐Bezerra, M., & Cohen, D. E. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170012 · Cited by 1,324
Fructose, insulin resistance, and metabolic dyslipidemia
Basciano, H., Federico, L. M., & Adeli, K. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-5 · Cited by 858
Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types
Buettner, R., Parhofer, K. G., Woenckhaus, M., Wrede, C. E., Kunz-Schughart, L. A., Schölmerich, J., & Bollheimer, L. C. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01909 · Cited by 704
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Metadata
- Authors
- den Boer, M., Voshol, P. J., Kuipers, F., Havekes, L. M., & Romijn, J. A.
- Affiliations
- From TNO Prevention and Health (M.d.B., P.J.V., L.M.H.), Gaubius Laboratory Leiden, Leiden, The Netherlands; Department of Endocrinology and Diabetes (M.d.B., P.J.V., J.A.R.), Department of General Internal Medicine (L.M.H.), and Department of Cardiology (L.M.H.), Leiden University Medical Center, Leiden, The Netherlands; and Center for Liver, Digestive, and Metabolic Diseases (F.K.), Department of Pediatrics, University Hospital Groningen, Groningen, The Netherlands.
- Leiden University (NL)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-04
- Volume
- 24
- Issue
- 4
- Pages
- 644-649
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2160518844
- Cited by
- 260
- References
- 49
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 15 · 2015: 17 · 2014: 5 · 2013: 6 · 2012: 16
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- hepatic steatosis, metabolic syndrome, non-alcoholic fatty liver disease, triglyceride accumulation, hepatic insulin resistance, visceral obesity, dyslipidemia, type 2 diabetes, rodent models
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Dogs, Fatty Acids, Fatty Liver, Glucose, Homeostasis, Humans, Hyperlipidemias, Insulin Resistance, Liver, Models, Biological, Obesity, Rats, Zucker, Transcription, Genetic, Triglycerides, Models, Animal, Metabolic Syndrome, Mice, Rats
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