Havekes, Louis M.

Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3

Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 539

Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models

den Boer, M., Voshol, P. J., Kuipers, F., Havekes, L. M., & Romijn, J. A. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 260

Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity

Coomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., van Dijk, K. W., Biermasz, N. R., et al. (2013) · The FASEB Journal

Circadian rhythm and melatoninSleep and Work-Related Fatigue

Cited by 252

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J., Frants, R. R., & Havekes, L. M. (1993) · Journal of Biological Chemistry

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 214

Induction of Atherosclerotic Plaque Rupture in Apolipoprotein E −/− Mice After Adenovirus-Mediated Transfer of p53

von der Thüsen, J. H., van Vlijmen, B. J. M., Hoeben, R. C., Kockx, M. M., Havekes, L. M., van Berkel, T. J. C., & Biessen, E. A. L. (2002) · Circulation

Atherosclerosis and Cardiovascular DiseasesCerebrovascular and Carotid Artery Diseases

Cited by 203

The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?

Willems van Dijk, K., Rensen, P. C., Voshol, P. J., & Havekes, L. M. (2004) · Current Opinion in Lipidology

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 154

Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies

Geerling, J. J., Boon, M. R., Kooijman, S., Parlevliet, E. T., Havekes, L. M., Romijn, J. A., Meurs, I. M., & Rensen, P. C. N. (2014) · Journal of Lipid Research

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 137

Protection From Obesity in Mice Lacking the VLDL Receptor

Goudriaan, J. R., Tacken, P. J., Dahlmans, V. E. H., Gijbels, M. J. J., van Dijk, K. W., Havekes, L. M., & Jong, M. C. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersLipid metabolism and biosynthesis

Cited by 133

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age

Mooijaart, S. P., Berbée, J. F. P., van Heemst, D., Havekes, L. M., de Craen, A. J. M., Slagboom, P. E., Rensen, P. C. N., & Westendorp, R. G. J. (2006) · PLoS Medicine

Lipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Cited by 129

Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels

Smit, M., de Knijff, P., Rosseneu, M., Bury, J., Klasen, E., Frants, R., & Havekes, L. (1988) · Human Genetics

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 127

Exendin‐4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration

Wang, Y., Parlevliet, E. T., Geerling, J. J., van der Tuin, S. J. L., Zhang, H., Bieghs, V, Jawad, A. H. M., Shiri‐Sverdlov, R., Bot, I., de Jager, S. C. A., et al. (2014) · British Journal of Pharmacology

Atherosclerosis and Cardiovascular DiseasesLiver Disease Diagnosis and Treatment

Cited by 126

White Adipose Tissue: Getting Nervous

Fliers, E., Kreier, F., Voshol, P. J., Havekes, L. M., Sauerwein, H. P., Kalsbeek, A., Buijs, R. M., & Romijn, J. A. (2003) · Journal of Neuroendocrinology

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 114

Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin

van den Hoek, A. M., Voshol, P. J., Karnekamp, B. N., Buijs, R. M., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 109

Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree.

de Knijff, P., van den Maagdenberg, A. M., Stalenhoef, A. F., Leuven, J. A., Demacker, P. N., Kuyt, L. P., Frants, R. R., & Havekes, L. M. (1991) · Journal of Clinical Investigation

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 100

The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis

Goudriaan, J. R., Santo, S. M. S. E., Voshol, P. J., Teusink, B., van Dijk, K. W., van Vlijmen, B. J. M., Romijn, J. A., Havekes, L. M., & Rensen, P. C. N. (2004) · Journal of Lipid Research

Lipid metabolism and disordersLipid metabolism and biosynthesis

Cited by 100

Apolipoprotein E3-Leiden. A new variant of human apolipoprotein E associated with familial type III hyperlipoproteinemia

Havekes, L., de Wit, E., Leuven, J. G., Klasen, E., Utermann, W., Weber, W., & Beisiegel, U. (1986) · Human Genetics

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 99

Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

Mulder, M., Jansen, P. J., Janssen, B. J. A., van de Berg, W. D. J., van der Boom, H., Havekes, L. M., de Kloet, R. E., Ramaekers, F. C. S., & Blokland, A. (2004) · Neurobiology of Disease

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 98

GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

Parlevliet, E. T., Wang, Y., Geerling, J. J., Schröder-Van der Elst, J. P., Picha, K., O'Neil, K., Stojanovic-Susulic, V., Ort, T., Havekes, L. M., Romijn, J. A., et al. (2012) · PLoS ONE

Lipid metabolism and disordersLiver Disease Diagnosis and Treatment

Cited by 97

Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo

Rensen, P. C. N., Jong, M. C., van Vark, L. C., van der Boom, H., Hendriks, W. L., van Berkel, T. J. C., Biessen, E. A. L., & Havekes, L. M. (2000) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 86

Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127

Wardell, M. R., Weisgraber, K. H., Havekes, L. M., & Rall, S. C. (1989) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 80

Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 → Cys) homozygotes is associated with hyperinsulinemia

de Beer, F., Stalenhoef, A. F. H., Hoogerbrugge, N., Kastelein, J. J. P., Gevers Leuven, J. A., van Duijn, C. M., Havekes, L. M., & Smelt, A. H. M. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 74

Apolipoprotein E Protects against Neuropathology Induced by a High-Fat Diet and Maintains the Integrity of the Blood-Brain Barrier during Aging

Mulder, M., Blokland, A., van den Berg, D.-J., Schulten, H., Bakker, A. H. F., Terwel, D., Honig, W., de Kloet, E. R., Havekes, L. M., Steinbusch, H. W. M., et al. (2001) · Laboratory Investigation

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 74

Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

Boesten, L. S. M., Zadelaar, S. M., De Clercq, S., Francoz, S., van Nieuwkoop, A., Biessen, E. A. L., Hofmann, F., Feil, S., Feil, R., Jochemsen, A. G., et al. (2006) · Cell Death & Differentiation

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 70

Domains of Apolipoprotein E Contributing to Triglyceride and Cholesterol Homeostasis in Vivo

Kypreos, K. E., van Dijk, K. W., van der Zee, A., Havekes, L. M., & Zannis, V. I. (2001) · Journal of Biological Chemistry

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 62