Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men
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Even small amounts of weight loss induced by a negative energy balance affect many variables pertaining to body-fat composition and lipid metabolism.
“Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [24]
Variables pertaining to body-fat composition and lipid metabolism probably contribute to the metabolic abnormalities associated with obesity.
“Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [24]
Several studies have shown a strong relationship among nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes mellitus.
“Several studies have shown a strong relationship among nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes mellitus.1–3”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [2]
Nonalcoholic fatty liver disease has an important role in causing hepatic insulin resistance.
“There is now strong evidence that nonalcoholic fatty liver disease has an important role in causing hepatic insulin resistance.1–3,23–27”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [2]
There is increasing evidence for a causal relationship between hepatic steatosis and hepatic insulin resistance in rodent models and in patients with nonalcoholic fatty liver disease.
“There is increasing evidence for a causal relationship between hepatic steatosis and hepatic insulin resistance both in rodent models with hepatic steatosis and in patients with nonalcoholic fatty liver disease (4, 18-25).”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [20]
Fatty acid-induced reductions in insulin receptor number and function in the liver may also reduce hepatic insulin clearance, causing systemic hyperinsulinemia, itself a contributor to both insulin resistance and reduced mitochondrial function.
“Fatty acid-induced reductions in insulin receptor number and function in the liver (211) may also reduce hepatic insulin clearance (226), causing systemic hyperinsulinemia, itself a contributor to both insulin resistance and reduced mitochondrial function (214,227,228).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [226]
The associations between liver fat and hepatic insulin resistance have previously been reported by Bajaj et al in 14 type 2 diabetic patients, and by us in nondiabetic subjects and type 2 diabetic patients treated with insulin.
“The associations between liver fat and hepatic insulin resistance have previously been reported by Bajaj et al, 62 who studied 14 type 2 diabetic patients, and by us in nondiabetic subjects 24,39 and type 2 diabetic patients treated with insulin. 36,38”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [39]
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- Authors
- Seppala-Lindroos, A.
- Corresponding author
- Seppala-Lindroos, A.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-07-01
- Volume
- 87
- Issue
- 7
- Pages
- 3023-3028
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4237246788
- Cited by
- 168
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2020: 2 · 2018: 2 · 2016: 7 · 2015: 3 · 2014: 7 · 2013: 13 · 2012: 23
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- hepatic lipid accumulation, insulin suppression, glucose production, serum free fatty acids, obesity, insulin resistance, hepatic glucose metabolism, non-obese men
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