Cited by 1,024Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

Seppala-Lindroos, A.·2002·Journal of Clinical Endocrinology & Metabolism

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Crossref · 10.1210/jc.87.7.3023

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0 citation errors · 0 not checkable

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  • Even small amounts of weight loss induced by a negative energy balance affect many variables pertaining to body-fat composition and lipid metabolism.

    “Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
  • Variables pertaining to body-fat composition and lipid metabolism probably contribute to the metabolic abnormalities associated with obesity.

    “Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
  • Several studies have shown a strong relationship among nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes mellitus.

    “Several studies have shown a strong relationship among nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes mellitus.1–3”
  • Nonalcoholic fatty liver disease has an important role in causing hepatic insulin resistance.

    “There is now strong evidence that nonalcoholic fatty liver disease has an important role in causing hepatic insulin resistance.1–3,23–27”
  • There is increasing evidence for a causal relationship between hepatic steatosis and hepatic insulin resistance in rodent models and in patients with nonalcoholic fatty liver disease.

    “There is increasing evidence for a causal relationship between hepatic steatosis and hepatic insulin resistance both in rodent models with hepatic steatosis and in patients with nonalcoholic fatty liver disease (4, 18-25).”

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Authors
Seppala-Lindroos, A.
Corresponding author
Seppala-Lindroos, A.
Venue
Journal of Clinical Endocrinology & Metabolism
Published
2002-07-01
Volume
87
Issue
7
Pages
3023-3028
ISSN
0021-972X (ISSN-L)
OpenAlex
W4237246788
Cited by
168
References
0
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2020: 2 · 2018: 2 · 2016: 7 · 2015: 3 · 2014: 7 · 2013: 13 · 2012: 23
FWCI
4.04
Type
journal article
Language
en
Open access
closed
Locations
The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
hepatic lipid accumulation, insulin suppression, glucose production, serum free fatty acids, obesity, insulin resistance, hepatic glucose metabolism, non-obese men

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