Cited by 1,618Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Oxidative Stress and Vascular Disease

Madamanchi, Nageswara R., Vendrov, Aleksandr, Runge, Marschall S.·2005·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000150649.39934.13

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Abstract

Growing evidence indicates that chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is integral in the development of cardiovascular diseases (CVD). These ROS can be released from nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, lipoxygenase, mitochondria, or the uncoupling of nitric oxide synthase in vascular cells. ROS mediate various signaling pathways that underlie vascular inflammation in atherogenesis: from the initiation of fatty streak development through lesion progress to ultimate plaque rupture. Various animal models of oxidative stress support the notion that ROS have a causal role in atherosclerosis and other cardiovascular diseases. Human investigations also support the oxidative stress hypothesis of atherosclerosis. Oxidative stress is the unifying mechanism for many CVD risk factors, which additionally supports its central role in CVD. Despite the demonstrated role of antioxidants in cellular and animal studies, the ineffectiveness of antioxidants in reducing cardiovascular death and morbidity in clinical trials has led many investigators to question the importance of oxidative stress in human atherosclerosis. Others have argued that the prime factor for the mixed outcomes from using antioxidants to prevent CVD may be the lack of specific and sensitive biomarkers by which to assess the oxidative stress phenotypes underlying CVD. A better understanding of the complexity of cellular redox reactions, development of a new class of antioxidants targeted to specific subcellular locales, and the phenotype-genotype linkage analysis for oxidative stress will likely be avenues for future research in this area as we move toward the broader use of pharmacological and regenerative therapies in the treatment and prevention of CVD.

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“…such as cancer (Toyokuni, 1998), autoimmune disorders (Gilgun-Sherki et al., 2004), diabetes (Matteucci et al., 2004), atherosclerosis and stroke (Madamanchi et al., 2005), supporting the hypothesis that oxidative stress is a normal by-product of ageing rather than the principal cause of…”
Background
Vascular Dysfunction and Chronic Obstructive Pulmonary Disease
Ives, S. J., Harris, R. A., Witman, M. A., Fjeldstad, A. S., Garten, R. S., McDaniel, J., Wray, D. W., & Richardson, R. S. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02255 · Cited by 82
“Numerous mechanisms could contribute to this reduced total antioxidant capacity, such as reduced activity of superoxide dismutase, catalase, and glutathione peroxidase.(36,54,55) In the current study, basal levels of factors contributing to the antioxidant defense system, including superoxide dismutase activity and vi…”
Result
Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam
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“Oxidative damage by free radicals has been well investigated within the context of oxidant/antioxidant balance [8].”
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ROS-activated calcium signaling mechanisms regulating endothelial barrier function
Di, A., Mehta, D., & Malik, A. B. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.02.002 · Cited by 83
“ROS stimulate the activation of NF-κB[103], which in turn controls the expression of key genes involved in mediating lung vascular inflammation and injury[103-105].”
Background
The role of oxidative stress in patients with recurrent pregnancy loss: a review
Zejnullahu, V. A., Zejnullahu, V. A., & Kosumi, E. (2021) · Reproductive Health · doi:10.1186/s12978-021-01257-x · Cited by 88
“Therefore, the beneficial effects of ROS are achievable within physiological levels and deviation from redox window (as oxidative or reductive stresses) [29] will be associated with different pathologies including neurodegenerative diseases [30] diabetes [31] cardiovascular disease and atherosclerosis [32] rheumatoid…”
Background
Influence of Antiretroviral Therapy on Oxidative Stress and Cardiovascular Risk: A Prospective Cross-Sectional Study in HIV-Infected Patients
Masiá, M., Padilla, S., Bernal, E., Almenar, M., Molina, J., Hernández‐Aguado, I., Graells, M. L., & Gutiérrez, F. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.07.025 · Cited by 81
Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice
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Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Ecotoxicological Impacts
Berríos-Rolón, P. J., Cotto, M. C., & Márquez, F. (2025) · Toxics · doi:10.3390/toxics13040321 · Cited by 80
Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation
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Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast
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“The underlying reason for most of these shortcomings lies in the fact that the current therapies do not address the underlying pathophysiology of AF.”
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Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease
Grahame, T. J., & Schlesinger, R. B. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-21 · Cited by 87
“Thus, it may be that the mixed results in reducing CVD with antioxidants may be due partly to the types of anti-oxidants customarily used, and/or in part to the lack of specific and sensistive biomarkers by which to assess oxidative stress phenotypes that underly CVD [108].”
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Current concepts on the pathophysiology of portal hypertension
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An Easy and Reliable Automated Method to Estimate Oxidative Stress in the Clinical Setting
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Human Paraoxonase-2 (PON2): Protein Functions and Modulation
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Time-Restricted Eating to Improve Cardiovascular Health
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Background
Platelets in Thrombosis and Atherosclerosis
Bravo, G. M., Annarapu, G. K., Carmona, E., Nawarskas, J. J., Clark, R. M., Novelli, E. M., & Mota, R. I. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.05.010 · Cited by 92
The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications
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“Monocytes LOX-1 mainly derived from membrane-bound NAD(P)H oxidase and mitochondria, whereas additional superoxide is generated by XO catalyzing hypoxanthine and xanthine to uric acid [10].”
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling
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“Pathophysiological stimuli that induce endothelial activation via NADPH oxidase-mediated ROS-induced signal transduction and alteration of intracellular Ca(2) ion homeostasis are now considered to be major contributors to the pathogenesis of atherosclerotic coronary artery diseases (32).”
Background
Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells
Ramprasath, T., Manivasagam, S., Vasudevan, V., Sasikumar, S., Yuvaraj, S., & Selvam, G. S. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0318-3 · Cited by 77
Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis
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Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium
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Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: An open question
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Control of SUMO and Ubiquitin by ROS: Signaling and disease implications
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Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway
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Planar Catechin Analogues with Alkyl Side Chains: A Potent Antioxidant and an α-Glucosidase Inhibitor
Hakamata, W., Nakanishi, I., Masuda, Y., Shimizu, T., Higuchi, H., Nakamura, Y., Saito, S., Urano, S., Oku, T., Ozawa, T., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057763c · Cited by 76
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“Additionally, elevated ROS production has been implicated in the pathogenesis of numerous diseases (Madamanchi et al., 2005; Lin and Beal, 2006; Rezaie et al., 2007).”
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Mean Corpuscular Volume and Mortality in Patients with CKD
Hsieh, Y., Chang, C., Kor, C., Yang, Y., Wen, Y., & Chiu, P. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00970116 · Cited by 75
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis
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“and proinflammatory conditioning, which are integral in the development of CVD (12,13).”
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Notoginsenoside R1 inhibits TNF-α-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway
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IL-9 aggravates the development of atherosclerosis in ApoE-/- mice
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Oxidative Stress and Microvessel Barrier Dysfunction
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Authors: Madamanchi, N. R., Vendrov, A., & Runge, M. S.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Madamanchi, Nageswara R.
Vendrov, Aleksandr
Runge, Marschall S.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-01
Volume: 25
Issue: 1
Pages: 29-38
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000150649.39934.13
OpenAlex: W2109698138
Cited by: 1,618
References: 135
Citations by year: 2026: 47 · 2025: 46 · 2024: 42 · 2023: 53 · 2022: 61 · 2021: 62 · 2020: 73 · 2019: 73 · 2018: 57 · 2017: 75 · 2016: 78 · 2015: 105 · 2014: 111 · 2013: 104 · 2012: 95
FWCI: 7.02
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, reactive oxygen species, atherosclerosis, vascular disease, cardiovascular disease, NADPH oxidase, xanthine oxidase, lipoxygenase, nitric oxide synthase uncoupling, vascular inflammation, atherogenesis, antioxidants, redox signaling, biomarkers, cardiovascular risk factors
MeSH terms: Animals, Humans, Vascular Diseases, Oxidative Stress

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