Premature Senescence of Vascular Cells Is Induced by HIV Protease Inhibitors: Implication of Prelamin A and Reversion by Statin

Oxidative Stress and Vascular Disease

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Risk of Myocardial Infarction in Patients with HIV Infection Exposed to Specific Individual Antiretroviral Drugs from the 3 Major Drug Classes: The Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) Study

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Direct Evidence of Endothelial Oxidative Stress With Aging in Humans

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

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Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

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A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

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Increased risk of myocardial infarction in HIV-infected patients in France, relative to the general population

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Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome

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Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

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Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence

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A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

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Hutchinson–Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody

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New Links Between Inflammation and Thrombosis

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Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Vascular cell senescence and vascular aging

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HIV Protease Inhibitor Ritonavir Induces Cytotoxicity of Human Endothelial Cells

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Mechanisms of cardiovascular disease in accelerated aging syndromes

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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

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Coronary Aging in HIV‐Infected Patients

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Edible vaccines: not quite ready for prime time

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Senescence-associated cell death of human endothelial cells: the role of oxidative stress

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Molecular Mechanisms of HIV Protease Inhibitor-Induced Endothelial Dysfunction

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Contribution of Mitochondrial Dysfunction and Oxidative Stress to Cellular Premature Senescence Induced by Antiretroviral Thymidine Analogues

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HAART Drugs Induce Oxidative Stress in Human Endothelial Cells and Increase Endothelial Recruitment of Mononuclear Cells: Exacerbation by Inflammatory Cytokines and Amelioration by Antioxidants

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Cardiovascular complications and atherosclerotic manifestations in the HIV-infected population: type, incidence and associated risk factors

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Introduction: HIV/AIDS and Aging.

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Roles and Mechanisms of Human Immunodeficiency Virus Protease Inhibitor Ritonavir and Other Anti-Human Immunodeficiency Virus Drugs in Endothelial Dysfunction of Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells

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Human immunodeficiency virus per se exerts atherogenic effects

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Cardiovascular Risk in Patients with HIV Infection

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A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

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Antiretrovirals Induce Direct Endothelial Dysfunction In Vivo

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HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries

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HIV-protease inhibitors block the enzymatic activity of purified Ste24p

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HIV protease inhibitor ritonavir increases endothelial monolayer permeability

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How HIV protease inhibitors promote atherosclerotic lesion formation

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HIV and Coronary Heart Disease

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p53 and metabolism: from mechanism to therapeutics

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Premature and accelerated aging: HIV or HAART?

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Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses

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Basic science and pathogenesis of ageing with HIV

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MicroRNA-34a: the bad guy in age-related vascular diseases

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Cellular senescence is associated with reorganization of the microtubule cytoskeleton

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Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

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HIV protease inhibitor exposure predicts cerebral small vessel disease

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HIV-associated cellular senescence: A contributor to accelerated aging

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White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on combination antiretroviral therapy

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The Oxygen Paradox, the French Paradox, and age-related diseases

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Role of inflammation in HIV-1 disease progression and prognosis

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HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin

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Nuclear envelope-related lipodystrophies

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Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

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Astrocyte senescence and metabolic changes in response to HIV antiretroviral therapy drugs

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LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

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Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment

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The struggle of a good friend getting old: cellular senescence in viral responses and therapy

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Dissecting the molecular mechanisms that impair stress granule formation in aging cells

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Mechanisms of immune aging in HIV

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A pathway linking oxidative stress and the Ran GTPase system in progeria

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Arterial Ageing

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Impact of Darunavir, Atazanavir and Lopinavir Boosted with Ritonavir on Cultured Human Endothelial Cells: Beneficial Effect of Pravastatin

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Association of antiretroviral therapy with brain aging changes among HIV-infected adults

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Pediatric Human Immunodeficiency Virus infection and cancer in the Highly Active Antiretroviral Treatment (HAART) era

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