Cited by 509Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

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Phagocytosis of Apoptotic Cells by Macrophages Is Impaired in Atherosclerosis

Schrijvers, Dorien M., De Meyer, Guido R.Y., Kockx, Mark M., Herman, Arnold G., Martinet, Wim·2005·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/01.atv.0000166517.18801.a7

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Abstract

OBJECTIVE: Apoptotic cell death has been demonstrated in advanced human atherosclerotic plaques. Apoptotic cells (ACs) should be rapidly removed by macrophages, otherwise secondary necrosis occurs, which in turn elicits inflammatory responses and plaque progression. Therefore, we investigated the efficiency of phagocytosis of ACs by macrophages in atherosclerosis. METHODS AND RESULTS: Human endarterectomy specimens and human tonsils were costained for CD68 (macrophages) and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) (apoptosis). Free and phagocytized ACs were counted in both tissues. The ratio of free versus phagocytized AC was 19-times higher in human atherosclerotic plaques as compared with human tonsils, indicating a severe defect in clearance of AC. Impaired phagocytosis of AC was also detected in plaques from cholesterol-fed rabbits and did not further change with plaque progression. In vitro experiments with J774 or peritoneal mouse macrophages showed that several factors caused impaired phagocytosis of AC including cytoplasmic overload of macrophages with indigestible material (beads), free radical attack, and competitive inhibition among oxidized red blood cells, oxidized low-density lipoprotein and ACs for the same receptor(s) on the macrophage. CONCLUSIONS: Our data demonstrate that phagocytosis of ACs is impaired in atherosclerotic plaques, which is at least partly attributed to oxidative stress and cytoplasmic saturation with indigestible material.

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Authors: Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W.
Affiliations: University of Antwerp (BE)
From the Division of Pharmacology (D.M.S., G.R.Y.D.M., M.M.K., A.G.H., W.M.), University of Antwerp, Wilrijk, Belgium; and the Department of Pathology (M.M.K.), AZ Middelheim, Antwerp, Belgium
ORCID: Schrijvers, Dorien M.
Kockx, Mark M.
Martinet, Wim
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-06
Volume: 25
Issue: 6
Pages: 1256-1261
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000166517.18801.a7
OpenAlex: W2163327518
Cited by: 509
References: 42
Citations by year: 2026: 13 · 2025: 32 · 2024: 34 · 2023: 31 · 2022: 34 · 2021: 33 · 2020: 21 · 2019: 24 · 2018: 29 · 2017: 32 · 2016: 20 · 2015: 25 · 2014: 21 · 2013: 24 · 2012: 16
FWCI: 6.74
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: phagocytosis of apoptotic cells, macrophages, atherosclerosis, atherosclerotic plaque, secondary necrosis, oxidative stress, oxidized LDL, plaque progression, cholesterol-fed rabbits, tonsil
MeSH terms: Aged, Animals, Carotid Artery Diseases, Cytoplasm, Erythrocytes, Female, Humans, Lipoproteins, LDL, Male, Necrosis, Phagocytosis, Rabbits, Palatine Tonsil, Apoptosis, Macrophages, Peritoneal, Oxidative Stress, U937 Cells, Mice

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Phagocytosis of Apoptotic Cells by Macrophages Is Impaired in Atherosclerosis

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