The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis
Open accessAbstract
Accumulating evidence supports the notion that defective phagocytic clearance of dying cells, or defective “efferocytosis,” is causally linked to the progression of advanced atherosclerosis. In advanced atherosclerotic lesions, defective efferocytosis leads to post‐apoptotic necrosis, expansion of plaque necrotic cores, and susceptibility to atherothrombosis. Both macrophages and DC‐like efferocytes are juxtaposed near expanding necrotic cores, where they engage apoptotic cells. In this Viewpoint , we discuss how reduced efferocytosis by macrophages and CD11c HI DC‐like cells may combine to reduce overall plaque stability and therefore promote susceptibility to acute atherothrombosis.
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Failure to clear dead cells in atherosclerotic lesions causes accumulation of secondarily necrotic cells and formation of a highly inflammatory necrotic core.
“Failure to clear dead cells in the atherosclerotic lesion leads to the accumulation of secondarily necrotic cells and the formation of a highly inflammatory necrotic core188,189.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [189]
Defective efferocytosis has a particularly prominent role in atherosclerosis.
“The inability to clear apoptotic cells efficiently drives many diseases, but defective effero-cytosis has a particularly prominent role in atheroscle-rosis188–190.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [189]
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- Authors
- Thorp, E., Subramanian, M., & Tabas, I.
- Affiliations
- Northwestern University (US)
- Columbia University (US)
- Corresponding author
- Thorp, Edward
- Tabas, Ira
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2011-08-26
- Volume
- 41
- Issue
- 9
- Pages
- 2515-2518
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- PMC
- PMC3289088
- OpenAlex
- W2158038694
- Cited by
- 107
- References
- 51
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 14 · 2013: 9 · 2012: 10
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K99HL097021, HL-75662, P01HL054591, R01HL075662, R01HL107497, HL 54591)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- efferocytosis, macrophages, dendritic cells, advanced atherosclerosis, atherothrombosis, plaque stability, phagocytosis
- MeSH terms
- Animals, Dendritic Cells, Disease Susceptibility, Humans, Macrophages, Necrosis, Phagocytosis, Thrombosis, Apoptosis, Disease Progression, CD11c Antigen, Atherosclerosis
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