Cited by 107Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

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Thorp, Edward, Subramanian, Manikandan, Tabas, Ira·2011·European Journal of Immunology

Abstract

Accumulating evidence supports the notion that defective phagocytic clearance of dying cells, or defective “efferocytosis,” is causally linked to the progression of advanced atherosclerosis. In advanced atherosclerotic lesions, defective efferocytosis leads to post‐apoptotic necrosis, expansion of plaque necrotic cores, and susceptibility to atherothrombosis. Both macrophages and DC‐like efferocytes are juxtaposed near expanding necrotic cores, where they engage apoptotic cells. In this Viewpoint , we discuss how reduced efferocytosis by macrophages and CD11c HI DC‐like cells may combine to reduce overall plaque stability and therefore promote susceptibility to acute atherothrombosis.

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Research works printed but not linked: 2

  1. [18]Tabas I Nat. Rev. Immunol 2010 10 34 36 PMC2854623 19960040
  2. [44]Miksa M Int. J. Mol. Med 2008 22 743 748 19020771 PMC2787083

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Authors
Thorp, E., Subramanian, M., & Tabas, I.
Affiliations
  • Northwestern University (US)
  • Columbia University (US)
Corresponding author
  • Thorp, Edward
  • Tabas, Ira
Venue
European Journal of Immunology
Publisher
Wiley
Published
2011-08-26
Volume
41
Issue
9
Pages
2515-2518
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
OpenAlex
W2158038694
Cited by
107
References
51
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 14 · 2013: 9 · 2012: 10
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (K99HL097021, HL-75662, P01HL054591, R01HL075662, R01HL107497, HL 54591)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
efferocytosis, macrophages, dendritic cells, advanced atherosclerosis, atherothrombosis, plaque stability, phagocytosis
MeSH terms
Animals, Dendritic Cells, Disease Susceptibility, Humans, Macrophages, Necrosis, Phagocytosis, Thrombosis, Apoptosis, Disease Progression, CD11c Antigen, Atherosclerosis

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