Cited by 563Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.

Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

Moore, Kathryn J., Freeman, Mason W.·2006·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/01.atv.0000229218.97976.43

Open this paper in CoChat — free account

Abstract

Atherosclerotic vascular disease arises as a consequence of the deposition and retention of serum lipoproteins in the artery wall. Macrophages in lesions have been shown to express > or = 6 structurally different scavenger receptors for uptake of modified forms of low-density lipoproteins (LDLs) that promote the cellular accumulation of cholesterol. Because cholesterol-laden macrophage foam cells are the primary component of the fatty streak, the earliest atherosclerotic lesion, lipid uptake by these pathways has long been considered a requisite and initiating event in the pathogenesis of atherosclerosis. Although the removal of proinflammatory modified LDLs from the artery wall via scavenger receptors would seem beneficial, the pathways distal to scavenger receptor uptake that metabolize the modified lipoproteins appear to become overwhelmed, leading to the accumulation of cholesterol-laden macrophages and establishment of a chronic inflammatory setting. These observations have led to the current dogma concerning scavenger receptors, which is that they are proatherogenic molecules. However, recent studies suggest that the effects of scavenger receptors on atherogenesis may be more complex. In addition to modified lipoprotein uptake, these proteins are now known to regulate apoptotic cell clearance, initiate signal transduction, and serve as pattern recognition receptors for pathogens, activities that may contribute both to proinflammatory and anti-inflammatory forces regulating atherogenesis. In this review, we focus on recent advances in our knowledge of scavenger receptor regulation and signal transduction, their roles in sterile inflammation and infection, and the potential impact of these pathways in regulating the balance of lipid accumulation and inflammation in the artery wall.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.0000229218.97976.43

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,026
An endothelial receptor for oxidized low-density lipoprotein
Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T., et al. (1997) · Nature · doi:10.1038/386073a0 · Cited by 1,386
CD36 is a receptor for oxidized low density lipoprotein
Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., & Protter, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50272-1 · Cited by 1,282
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages*
Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064
Self-citation
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Kodama, T., Freeman, M. W., Rohrer, L., Zabrecky, J. R., Matsudaira, P. T., & Krieger, M. (1990) · Nature · doi:10.1038/343531a0 · Cited by 1,036
Self-citation
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403249101 · Cited by 1,019
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000) · Nature Medicine · doi:10.1038/71517 · Cited by 1,014
CD36 is a sensor of diacylglycerides
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U., et al. (2005) · Nature · doi:10.1038/nature03253 · Cited by 873

Show all 94 references

Research works printed but not linked: 12

1980, Artery, 8, 208
1992, Am J Pathol, 141, 591
10.1161/atvb.17.11.2369 · DOI
1998, Lab Invest, 78, 423
10.1161/atvb.19.8.1960 · DOI
10.1161/atvb.20.12.2593 · DOI
10.1161/atvb.20.12.2600 · DOI
10.1161/atvb.19.5.1299 · DOI
10.1161/res.90.3.270 · DOI
10.1161/atvb.20.3.721 · DOI
10.1161/circ.99.24.3110 · DOI
10.1161/atvb.20.4.1107 · DOI

Sorted by citations

Items 101–200 of 563

The Role of Lipids and Lipoproteins in Atherosclerosis
Linton, M. F., Yancey, P. G., Davies, S. S., Jerome, W. G., Linton, E. F., Song, W., Doran, A. C., & Vickers, K. C. (2015) · Europe PMC (PubMed Central) · Cited by 108
Deletion of the murine scavenger receptor CD68
Song, L., Lee, C., & Schindler, C. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015412 · Cited by 108
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis
Joffre, J., Potteaux, S., Zeboudj, L., Loyer, X., Boufenzer, A., Laurans, L., Esposito, B., Vandestienne, M., de Jager, S. C. A., Hénique, C., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.10.015 · Cited by 117
The role of CD4+CD25+ regulatory T cells in macrophage-derived foam-cell formation
Lin, J., Li, M., Wang, Z., He, S., Ma, X., & Li, D. (2009) · Journal of Lipid Research · doi:10.1194/jlr.d000497 · Cited by 110
Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: Effects on uptake of oxidized LDL in macrophages as a potential mechanism
Fairé, U. D., Su, J., Hua, X., Frostegård, A. G., Halldin, M., Hellénius, M.-L., Wikström, M., Dahlbom, I., Grönlund, H., & Frostegård, J. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.05.003 · Cited by 104
Danger Signaling in Atherosclerosis
Zimmer, S., Grebe, A., & Latz, E. (2015) · Circulation Research · doi:10.1161/circresaha.116.301135 · Cited by 106
Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
Stancu, C. S., Toma, L., & Sima, A. V. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1437-1 · Cited by 110
Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis
Gleissner, C. A., Leitinger, N., & Ley, K. F. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.089854 · Cited by 103
CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding
Jay, A. G., Chen, A. N., Paz, M. A., Hung, J. P., & Hamilton, J. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.627026 · Cited by 99
Inhibition of epidermal growth factor receptor attenuates atherosclerosis via decreasing inflammation and oxidative stress
Wang, L., Huang, Z., Huang, W., Chen, X., Shan, P., Zhong, P., Khan, Z. A., Wang, J., Fang, Q., Liang, G., et al. (2017) · Scientific Reports · doi:10.1038/srep45917 · Cited by 96
Endoplasmic reticulum stress and lipid dysregulation
Colgan, S. M., Al‐Hashimi, A., & Austin, R. C. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001742 · Cited by 97
NASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages
Bieghs, V., Rensen, P. C. N., Hofker, M. H., & Shiri‐Sverdlov, R. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.08.041 · Cited by 96
Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease
Stephen, S. L., Freestone, K., Dunn, S., Twigg, M. W., Homer‐Vanniasinkam, S., Walker, J. H., Wheatcroft, S. B., & Ponnambalam, S. (2010) · International Journal of Hypertension · doi:10.4061/2010/646929 · Cited by 97
Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis
Gibson, F. C. (2007) · Frontiers in bioscience · doi:10.2741/2822 · Cited by 93
Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice: Role of Lipoxidation via Receptor-Mediated Mechanisms
Iacobini, C., Menini, S., Ricci, C., Scipioni, A., Sansoni, V., Cordone, S., Taurino, M., Serino, M., Marano, G., Federici, M., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.186791 · Cited by 91
CD36/Fatty Acid Translocase, An Inflammatory Mediator, Is Involved in Hyperlipidemia-Induced Exacerbation in Ischemic Brain Injury
Kim, E., Tolhurst, A. T., Qin, L. Y., Chen, X.-Y., Febbraio, M., & Cho, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0982-08.2008 · Cited by 81
Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity
Zhang, Y., Li, Q., Welsh, W. J., Moghe, P. V., & Uhrich, K. E. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.028 · Cited by 87
Lipid scavenging macrophages and inflammation
Vogel, A., Brunner, J. S., Hajto, A., Sharif, O., & Schabbauer, G. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159066 · Cited by 92
Low levels of IgM antibodies against phosphorylcholine—A potential risk marker for ischemic stroke in men
Sjöberg, B. G., Su, J., Dahlbom, I., Grönlund, H., Wikström, M., Hedblad, B., Berglund, G. L., Fairé, U. D., & Frostegård, J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.009 · Cited by 87
Biocompatibility of total joint replacements: A review
Goodman, S. B., Gómez‐Barrena, E., Takagi, M., & Konttinen, Y. T. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32063 · Cited by 91
Reduction in dietary omega-6 polyunsaturated fatty acids: Eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
Wang, S., Wu, D., Matthan, N. R., Lamon‐Fava, S., Lecker, J. L., & Lichtenstein, A. H. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.024 · Cited by 85
Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys
Tang, C., Kanter, J. E., Bornfeldt, K., LeBoeuf, R. C., & Oram, J. F. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m003525 · Cited by 85
Dietary Green Tea Extract Lowers Plasma and Hepatic Triglycerides and Decreases the Expression of Sterol Regulatory Element-Binding Protein-1c mRNA and Its Responsive Genes in Fructose-Fed, Ovariectomized Rats
Shrestha, S., Ehlers, S. J., Lee, J., Fernández, M. L., & Koo, S. I. (2009) · Journal of Nutrition · doi:10.3945/jn.108.103341 · Cited by 85
CXCL16/SR-PSOX—A friend or a foe in atherosclerosis?
Sheikine, Y., & Sirsjö, A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.034 · Cited by 82
Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice
Jagavelu, K., Tietge, U. J. F., Gaestel, M., Drexler, H., Schieffer, B., & Bavendiek, U. (2007) · Circulation Research · doi:10.1161/circresaha.107.156075 · Cited by 78
Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI
Sun, B., Boyanovsky, B. B., Connelly, M. A., Shridas, P., van der Westhuyzen, D. R., & Webb, N. R. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700163-jlr200 · Cited by 80
Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis
Liu, Z., Zhu, H., Dai, X., Wang, C., Ding, Y., Song, P., & Zou, M. (2017) · Circulation Research · doi:10.1161/circresaha.117.311546 · Cited by 79
Oxidized Low Density Lipoprotein Induced Caspase-1 Mediated Pyroptotic Cell Death in Macrophages: Implication in Lesion Instability?
Lin, J., Shou, X., Mao, X., Dong, J., Mohabeer, N., Kushwaha, K. K., Wang, L., Su, Y., Fang, H., & Li, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062148 · Cited by 79
The TNF-Like Protein 1A–Death Receptor 3 Pathway Promotes Macrophage Foam Cell Formation In Vitro
McLaren, J. E., Calder, C. J., McSharry, B. P., Sexton, K., Salter, R. C., Singh, N. N., Wilkinson, G. W. G., Wang, E. C. Y., & Ramji, D. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903782 · Cited by 79
Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis
Lien, C., Chen, S., Tsai, M., & Lin, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716332 · Cited by 77
A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation
Lee, J., Lim, E., Park, D., Lee, S.-H., Kim, J.-R., & Baek, S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.08.022 · Cited by 76
Advanced lipoxidation end‐products mediate lipid‐induced glomerular injury: role of receptor‐mediated mechanisms
Iacobini, C., Menini, S., Ricci, P. C., Scipioni, A., Sansoni, V., Mazzitelli, G., Cordone, S., Pesce, C. M., Pugliese, F. R., Pricci, F., et al. (2009) · The Journal of Pathology · doi:10.1002/path.2536 · Cited by 76
Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response
Ding, X., Zheng, L., Yang, B., Wang, X., & Yin, Y. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s207185 · Cited by 75
Immunometabolism of AMPK in insulin resistance and atherosclerosis
Fullerton, M. D., Steinberg, G. R., & Schertzer, J. D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.02.004 · Cited by 73
Polymer‐based therapeutics: nanoassemblies and nanoparticles for management of atherosclerosis
Lewis, D. R., Kamisoglu, K., York, A. W., & Moghe, P. V. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.145 · Cited by 74
MK2: a novel molecular target for anti-inflammatory therapy
Duraisamy, S., Bajpai, M., Bughani, U., Dastidar, S. G., Ray, A., & Chopra, P. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.8.921 · Cited by 77
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment
Zhang, X., Centurion, F., Misra, A., Patel, S., & Gu, Z. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114709 · Cited by 76
Pathways of smooth muscle foam cell formation in atherosclerosis
Pryma, C. S., Ortega, C., Dubland, J. A., & Francis, G. A. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000574 · Cited by 72
The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health
Bui, T. V. A., Hwangbo, H., Lai, Y., Hong, S. B., Choi, Y.-J., Park, H., & Ban, K. (2023) · Korean Circulation Journal · doi:10.4070/kcj.2023.0048 · Cited by 70
Myeloid cells in atherosclerosis: initiators and decision shapers
Soehnlein, O., & Weber, C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0141-z · Cited by 70
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling
Zhou, M.-S., Chadipiralla, K., Mendez, A. J., Jaimes, E. A., Silverstein, R. L., Webster, K. A., & Raij, L. R. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00042.2013 · Cited by 78
Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
Fullerton, M. D., Ford, R. J., McGregor, C., LeBlond, N. D., Snider, S. A., Stypa, S., Day, E. A., Lhoták, Š., Schertzer, J. D., Austin, R. C., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m058875 · Cited by 70
Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation
Suzuki, Y., Tada‐Oikawa, S., Ichihara, G., Yabata, M., Izuoka, K., Suzuki, M., Sakai, K., & Ichihara, S. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.010 · Cited by 70
Linkage of Infection to Adverse Systemic Complications: Periodontal Disease, Toll-Like Receptors, and Other Pattern Recognition Systems
Wallet, S. M., Puri, V., & Gibson, F. C. (2018) · Vaccines · doi:10.3390/vaccines6020021 · Cited by 69
Nanotechnology applications for cardiovascular disease treatment: Current and future perspectives
Wang, D. K., Rahimi, M., & Filgueira, C. S. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102387 · Cited by 71
Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression
Cui, K., Gao, X., Wang, B., Wu, H., Kulandaisamy, A., Dong, Y., Xiao, Y., Jiang, X., Malovichko, M. V., Li, K. S., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.321723 · Cited by 70
Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
Su, J., Hua, X., Vikström, M., Leander, K., Gigante, B., Hellénius, M.-L., Fairé, U. D., & Frostegård, J. (2013) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-13-1 · Cited by 68
Role of Scavenger Receptor A Family in Lung Inflammation from Exposure to Environmental Particles
Thakur, S. A., Hamilton, R. F., & Holian, A. (2008) · Journal of Immunotoxicology · doi:10.1080/15476910802085863 · Cited by 66
Scavenger Receptor-AI–Targeted Iron Oxide Nanoparticles for In Vivo MRI Detection of Atherosclerotic Lesions
Segers, F. M., den Adel, B., Bot, I., van der Graaf, L. M., van der Veer, E. P., Gonzalez, W., Raynal, I., de Winther, M. P. J., Wodzig, W. K. W. H., Poelmann, R. E., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300707 · Cited by 66
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
Jeong, S.-J., Lee, M.-N., & Oh, G. T. (2017) · Endocrinology and Metabolism · doi:10.3803/enm.2017.32.1.41 · Cited by 65
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis
Zheng, G., Zhao, Y., Li, Z., Hua, Y., Zhang, J., Miao, Y., Guo, Y., Li, L., Shi, J., Dong, Z., et al. (2023) · Theranostics · doi:10.7150/thno.80250 · Cited by 66
Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease
Okamura, D. M., & Himmelfarb, J. (2009) · Pediatric Nephrology · doi:10.1007/s00467-009-1199-5 · Cited by 63
Vascular Endothelium: Functioning in Norm, Changes in Atherosclerosis and Current Dietary Approaches to Improve Endothelial Function
Chistiakov, D. A., Ревин, В. В., Sobenin, I. A., Orekhov, A. N., & Bobryshev, Y. V. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150226114031 · Cited by 71
From proliferation to proliferation: monocyte lineage comes full circle
Świrski, F. K., Hilgendorf, I., & Robbins, C. S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-013-0409-1 · Cited by 69
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential
Di, L., & Maiseyeu, A. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1886199 · Cited by 63
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease
Cho, K.-H., Kim, H.-J., Kamanna, V. S., & Vaziri, N. D. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.10.009 · Cited by 63
Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice
Usui, F., Kimura, H. J., Ohshiro, T., Tatsumi, K., Kawashima, A., Nishiyama, A., Iwakura, Y., Ishibashi, S., & Takahashi, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.02.117 · Cited by 62
Antigen-Induced Immunomodulation in the Pathogenesis of Atherosclerosis
Milioti, N., Bermúdez-Fajardo, A., Penichet, M. L., & Oviedo‐Orta, E. (2008) · Clinical and Developmental Immunology · doi:10.1155/2008/723539 · Cited by 62
Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Rojas, J., Salazar, J. J., Martínez, M. S., Palmar, J., Bautista, J., Chávez-Castillo, M., Gómez, A., & Bermúdez, V. (2015) · Scientifica · doi:10.1155/2015/851252 · Cited by 65
CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
Fan, J. J., Liu, L., Liu, Q., Cui, Y., Yao, B., Zhang, M., Gao, Y., Fu, Y., Dai, H., Pan, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07895-3 · Cited by 62
The mechanisms of traditional Chinese medicine underlying the prevention and treatment of atherosclerosis
Li, T., Zhi-Bin, W. A. N. G., Yang, L., Feng, C. A. O., Yang, B., & Kuang, H. (2019) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(19)30048-2 · Cited by 61
Formulation, characteristics and antiatherogenic bioactivities of CD36-targeted epigallocatechin gallate (EGCG)-loaded nanoparticles
Zhang, J., Nie, S., Martı́nez–Zaguilán, R., Sennoune, S. R., & Wang, S. F. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.001 · Cited by 60
Applying nanomedicine in maladaptive inflammation and angiogenesis
Alaarg, A., Pérez‐Medina, C., Metselaar, J. M., Nahrendorf, M., Fayad, Z. A., Storm, G., & Mulder, W. J. M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.009 · Cited by 60
Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis
Gleissner, C. A., Sanders, J. M., Nadler, J. L., & Ley, K. F. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158295 · Cited by 58
Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways
Wang, M., Kiss, R. S., Franklin, V., McBride, H. M., Whitman, S. C., & Marcel, Y. L. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600470-jlr200 · Cited by 59
Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice
Dai, X.-Y., Cai, Y., Mao, D.-D., Qi, Y., Tang, C., Xu, Q., Zhu, Y., Xu, M., & Wang, X. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.07.006 · Cited by 57
Effect of the oxLDL Binding Protein Fc-CD68 on Plaque Extension and Vulnerability in Atherosclerosis
Zeibig, S., Li, Z., Wagner, S., Holthoff, H., Ungerer, M., Bültmann, A., Uhland, K., Vogelmann, J., Simmet, T., Gawaz, M., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.240515 · Cited by 56
The Vascular Biology of Atherosclerosis
Libby, P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00043-3 · Cited by 57
Dietary Apigenin Reduces Induction of LOX-1 and NLRP3 Expression, Leukocyte Adhesion, and Acetylated Low-Density Lipoprotein Uptake in Human Endothelial Cells Exposed to Trimethylamine-N-Oxide
Yamagata, K., Hashiguchi, K., Yamamoto, H., & Tagami, M. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000747 · Cited by 57
Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis
Liu, Y., Yuan, P.-Z., Wu, J., & Hu, B. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02109-8 · Cited by 56
Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways
Li, Y., Zhou, M., Li, H., Dai, C., Yin, L., Liu, C., Li, Y., Zhang, E., Dong, X., Ji, H., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad796 · Cited by 55
Macrophage Heterogeneity: Relevance and Functional Implications in Atherosclerosis
Stöger, J. L., Goossens, P., & de Winther, M. P. J. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110790886983 · Cited by 54
Real‐time Raman and SRS imaging of living human macrophages reveals cell‐to‐cell heterogeneity and dynamics of lipid uptake
Stiebing, C., Meyer, T., Rimke, I., Matthäus, C., Schmitt, M. P., Stefan Lorkowski, A., & Popp, J. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201600279 · Cited by 55
Loss of the Lysophosphatidylcholine Effector, G2A, Ameliorates Aortic Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice
Parks, B. W., Lusis, A. J., & Kabarowski, J. H. S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000246774.02426.71 · Cited by 55
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Tahir, U. A., Katz, D. H., Ávila-Pacheco, J., Bick, A. G., Pampana, A., Robbins, J., Yu, Z., Chen, Z., Benson, M. D., Cruz, D. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32275-3 · Cited by 52
A Secreted Soluble Form of LR11, Specifically Expressed in Intimal Smooth Muscle Cells, Accelerates Formation of Lipid-Laden Macrophages
Ohwaki, K., Bujo, H., Jiang, M., Yamazaki, H., Schneider, W. J., & Saitō, Y. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.137091 · Cited by 54
PRR Function of Innate Immune Receptors in Recognition of Bacteria or Bacterial Ligands
Gulati, A., Kaur, D., Prasad, G. V. R. K., & Mukhopadhaya, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3065-0_18 · Cited by 61
Cardiac CT angiography in current practice: An American society for preventive cardiology clinical practice statement✰
Budoff, M. J., Lakshmanan, S., Toth, P. P., Hecht, H. S., Shaw, L. J., Maron, D. J., Michos, E. D., Williams, K. A., Sr., Nasir, K., Choi, A., et al. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100318 · Cited by 54
Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles
Wang, S., He, H., Mao, Y., Zhang, Y., & Gu, N. (2024) · Advanced Science · doi:10.1002/advs.202308298 · Cited by 59
IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages
Gabunia, K., Ellison, S. P., Kelemen, S. E., Kako, F., Cornwell, W. D., Rogers, T. J., Datta, P. K., Ouimet, M. I., Moore, K. J., & Autieri, M. V. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.023 · Cited by 53
Self-citation
Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway
Zhao, Z.-W., Zhang, M., Chen, L., Gong, D., Xia, X.-D., Yu, X.-H., Wang, S., Ou, X., Dai, X.-Y., Zheng, X., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.04.011 · Cited by 53
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska, P., Tipping, W. J., Marhuenda, E., Severi, P., Fomin, V., Yang, Z., Xiao, Q., Graham, D., Shanahan, C. M., & Iskratsch, T. (2023) · Advanced Science · doi:10.1002/advs.202308686 · Cited by 52
Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosis
Liu, H., Pietersz, G. A., Peter, K., & Wang, X. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01279-y · Cited by 53
TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2–CD36 inflammatory axis in macrophages
Zong, P., Feng, J., Yue, Z., Yu, A. S., Vacher, J., Jellison, E. R., Miller, B. A., Mori, Y., & Yue, L. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00027-7 · Cited by 51
Therapeutic approaches to drug targets in atherosclerosis
Jamkhande, P. G., Chandak, P. G., Dhawale, S. C., Barde, S. R., Tidke, P. S., & Sakhare, R. S. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.04.005 · Cited by 53
Conditional Targeting of Tumor Necrosis Factor Receptor–Associated Factor 6 Reveals Opposing Functions of Toll-Like Receptor Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis
Polykratis, A., Loo, G., Xanthoulea, S., Hellmich, M., & Pasparakis, M. (2012) · Circulation · doi:10.1161/circulationaha.112.100339 · Cited by 50
Intake of 3 Eggs per Day When Compared to a Choline Bitartrate Supplement, Downregulates Cholesterol Synthesis without Changing the LDL/HDL Ratio
Lemos, B. S., Vera, I., Blesso, C. N., & Fernández, M. L. (2018) · Nutrients · doi:10.3390/nu10020258 · Cited by 51
Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location
Xiang, P., Blanchard, V., & Francis, G. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.921597 · Cited by 53
Nur77 Decreases Atherosclerosis Progression in apoE−/− Mice Fed a High-Fat/High-Cholesterol Diet
Hu, Y., Zhang, P., Yang, J., Huang, J.-L., Ma, X., Li, S., Zhao, J., Hu, Y.-R., Wang, Y., Gao, J.-J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087313 · Cited by 50
Reverse Cholesterol Transport Pathway in Experimental Chronic Renal Failure
Moradi, H., Yuan, J. J., Ni, Z., Norris, K. C., & Vaziri, N. D. (2009) · American Journal of Nephrology · doi:10.1159/000210020 · Cited by 50
Inflammation and beyond: new directions and emerging drugs for treating atherosclerosis
Bertrand, M.-J., & Tardif, J. (2016) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2017.1269743 · Cited by 52
Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages
Liao, D., Wang, X., Li, M., Lin, P. H., Yao, Q. C., & Chen, C. (2008) · Blood · doi:10.1182/blood-2008-05-158048 · Cited by 49
Statins and foam cell formation: Impact on LDL oxidation and uptake of oxidized lipoproteins via scavenger receptors
Hofnagel, O., Luechtenborg, B., Weißen-Plenz, G., & Robenek, H. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.06.003 · Cited by 48
The Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease
Bezhaeva, T., Karper, J. C., Quax, P. H. A., & de Vries, M. R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.820962 · Cited by 48
Vav Family Rho Guanine Nucleotide Exchange Factors Regulate CD36-mediated Macrophage Foam Cell Formation
Rahaman, S. O., Swat, W., Febbraio, M., & Silverstein, R. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192450 · Cited by 47
Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells
Yew, K.-H., Carsten, B., & Harrison, C. J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.10.009 · Cited by 47
Effects of Egg Consumption and Choline Supplementation on Plasma Choline and Trimethylamine-N-Oxide in a Young Population
Lemos, B. S., Vera, I., Malysheva, O., Caudill, M. A., & Fernández, M. L. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1466213 · Cited by 46
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway
Zhuang, J., Liu, Y., Li, Z., Zhuang, Q.-Z., Tang, W., Xiong, Y., & Huang, X. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115733 · Cited by 45
The cell origins of foam cell and lipid metabolism regulated by mechanical stress in atherosclerosis
Ouyang, Z., Zhong, J., Shen, J., & Zeng, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1179828 · Cited by 44
Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes
Kuniyasu, A., Tokunaga, M., Yamamoto, T., Inoue, S., Obama, K., Kawahara, K., & Nakayama, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.11.011 · Cited by 44

Authors: Moore, K. J., & Freeman, M. W.
Affiliations: Harvard University (US)
ORCID: Moore, Kathryn J.
Freeman, Mason W.
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-08
Volume: 26
Issue: 8
Pages: 1702-1711
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000229218.97976.43
OpenAlex: W2093979977
Cited by: 562
References: 94
Citations by year: 2026: 16 · 2025: 20 · 2024: 26 · 2023: 25 · 2022: 32 · 2021: 30 · 2020: 23 · 2019: 27 · 2018: 22 · 2017: 16 · 2016: 26 · 2015: 27 · 2014: 28 · 2013: 36 · 2012: 37
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: scavenger receptors, atherosclerosis, modified low-density lipoprotein, foam cells, cholesterol accumulation, foam cell formation, lipid uptake, sterile inflammation, pattern recognition receptors, efferocytosis, signal transduction, atherogenesis
MeSH terms: Animals, Humans, Atherosclerosis, Lipid Metabolism, Receptors, Scavenger

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks