Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution
Abstract
OBJECTIVE: Intracellular tumor necrosis factor receptor-associated factors (TRAFs) translocation to lipid rafts is a key element in CD40-induced signaling. The purpose of this study was to investigate the influence of anthocyanin on CD40-mediated proinflammatory events in human endothelial cells and the underlying possible molecular mechanism. METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. TRAF-2 played pivotal role in CD40-NF-kappaB pathway as TRAF-2 small interference RNA (siRNA) diminished CD40-induced NF-kappaB activation and inflammation. TRAF-2 overexpression increased CD40-mediated NF-kappaB activation. Moreover, TRAF-2 almost totally recruited to lipid rafts after stimulation by CD40 ligand and depletion of cholesterol diminished CD40-mediated NF-kappaB activation. Exposure to anthocyanin not only interrupted TRAF-2 recruitment to lipid rafts but also decreased cholesterol content in Triton X-100 insoluble lipid rafts. However, anthocyanin did not influence the interaction between CD40 ligand and CD40 receptor. CONCLUSIONS: Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin.
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Berry anthocyanins affect lipid metabolism in cellular and animal models of dyslipidemia.
“Berry anthocyanins have also been shown to affect lipid metabolism in cellular and animal models of dyslipidemia.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [72]
Anthocyanin treatment of human umbilical vein endothelial cells regulates cholesterol distribution by interfering with the recruitment of TRAF-2 in lipid rafts, thereby inhibiting CD40-induced proinflammatory signaling.
“Anthocyanin treatment of human umbilical vein endothelial cells was further demonstrated to regulate cholesterol distribution by interfering with the recruitment of tumor necrosis factor receptor-associated factors (TRAF)-2 in lipid rafts, thereby inhibiting CD40-induced proinflammatory signaling.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [72]
Cites
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Functions of lipid rafts in biological membranes.
Brown, D. A., & London, E. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.111 · Cited by 3,027 · see citing works
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615 · see citing works
Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts
Brown, D. A., & London, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000005200 · Cited by 2,344 · see citing works
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091 · see citing works
Analysis and biological activities of anthocyanins
Kong, J.-M., Chia, L. S., Goh, N.-K., Chia, T., & Brouillard, R. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00438-2 · Cited by 1,689 · see citing works
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
Rothe, M., Sarma, V. J., Dixit, V. M., & Goeddel, D. V. (1995) · Science · doi:10.1126/science.7544915 · Cited by 1,050 · see citing works
Reduction of atherosclerosis in mice by inhibition of CD40 signalling
Mach, F., Schönbeck, U., Sukhova, G. K., Atkinson, E., & Libby, P. (1998) · Nature · doi:10.1038/28204 · Cited by 910 · see citing works
Mach, F., Schönbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1931 · Cited by 730 · see citing works
Scheiffele, P., Roth, M. G., & Simons, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5501 · Cited by 638 · see citing works
Emerging Themes in Lipid Rafts and Caveolae
Galbiati, F., Razani, B., & Lisanti, M. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00472-x · Cited by 567 · see citing works
CD40 Signaling and Plaque Instability
Schönbeck, U., & Libby, P. (2001) · Circulation Research · doi:10.1161/hh2401.101272 · Cited by 566 · see citing works
Inflammation, Immunity, and HMG-CoA Reductase Inhibitors
Schönbeck, U., & Libby, P. (2004) · Circulation · doi:10.1161/01.cir.0000129505.34151.23 · Cited by 497 · see citing works
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
Wong, B. R., Josien, R., Lee, S. Y., Vologodskaia, M., Steinman, R. M., & Choi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28355 · Cited by 458 · see citing works
Jou, S., Carpino, N., Takahashi, Y., Piekorz, R. P., Chao, J.-R., Carpino, N., Wang, D., & Ihle, J. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8580-8591.2002 · Cited by 357 · see citing works
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
Schönbeck, U., Sukhova, G. K., Shimizu, K., Mach, F., & Libby, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7458 · Cited by 356 · see citing works
A novel RING finger protein interacts with the cytoplasmic domain of CD40.
Hu, H., O’Rourke, K. M., Boguski, M. S., & Dixit, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43772-6 · Cited by 341 · see citing works
Ishida, T., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T., & Inoue, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9437 · Cited by 337 · see citing works
Ding, M., Feng, R., Wang, S. Y., Bowman, L. L., Lu, Y., Qian, Y. R., Castranova, V., Jiang, B., & Shi, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600861200 · Cited by 331 · see citing works
Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype
Lutgens, E., Cleutjens, K. B. J. M., Heeneman, S., Koteliansky, V., Burkly, L. C., & Daemen, M. J. A. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7464 · Cited by 272 · see citing works
Hauer, J., Püschner, S., Ramakrishnan, P., Simon, U., Bongers, M., Federle, C., & Engelmann, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500187102 · Cited by 242 · see citing works
Hostager, B. S., Catlett, I. M., & Bishop, G. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909520199 · Cited by 202 · see citing works
Atherosclerosis: The emerging role of inflammation and the CD40–CD40 ligand system
Phipps, R. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.6930 · Cited by 197 · see citing works
CD40 signaling in vascular cells: A key role in atherosclerosis?
Mach, F., Schönbeck, U., & Libby, P. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00309-2 · Cited by 193 · see citing works
CD40-CD40L Interactions in Atherosclerosis
Lutgens, E. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00142-6 · Cited by 183 · see citing works
Anthocyanins Induce Cholesterol Efflux from Mouse Peritoneal Macrophages
Xia, M., Hou, M., Zhu, H., Ma, J., Tang, Z., Wang, Q., Li, Y., Chi, D.-S., Yu, X., Zhao, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505047200 · Cited by 147 · see citing works
Arron, J. R., Pewzner‐Jung, Y., Walsh, M. C., Kobayashi, T., & Choi, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020774 · Cited by 142 · see citing works
Kim, H. J., Tsoy, I., Park, J. M., Chung, J. I., Shin, S. C., & Chang, K. C. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.062 · Cited by 123 · see citing works
Kalfin, R. E., Righi, A., Rosso, A. D., Bagchi, D., Generini, S., Guiducci, S., Matucci‐Cerinic, M., & Das, D. K. (2002) · Free Radical Research · doi:10.1080/1071576021000005249 · Cited by 90 · see citing works
TRAF6 Is Required for TRAF2-Dependent CD40 Signal Transduction in Nonhemopoietic Cells
Davies, C. C., Mak, T. W., Young, L. S., & Eliopoulos, A. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9806-9819.2005 · Cited by 64 · see citing works
Atherosclerosis and innate immune signaling
Laberge, M. A., Moore, K. J., & Freeman, M. W. (2005) · Annals of Medicine · doi:10.1080/07853890510007304 · Cited by 45 · see citing works
Zhang-Hoover, J., Sutton, A., & Stein‐Streilein, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3556 · Cited by 29 · see citing works
Chaudhuri, A., Orme, S., Eilam, S., & Cherayil, B. J. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.9.4244 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of NF-κB by TNF family cytokines
Hayden, M. S., & Ghosh, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.004 · Cited by 1,116 · see citing works
Nutraceuticals: Facts and fiction
Espı́n, J. C., García‐Conesa, M., & Tomás-Barberán, F. A. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.09.014 · Cited by 815 · see citing works
Basic biochemical mechanisms behind the health benefits of polyphenols
Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.006 · Cited by 748 · see citing works
Effects of Flavonoids and other Polyphenols on Inflammation
González, R., Ballester, I., López-Posadas, R., Suárez, M. D., Zarzuelo, A., Martínez‐Augustin, O., & de Medina, F. S. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903584094 · Cited by 572 · see citing works
Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence
de Pascual‐Teresa, S., Moreno, D. A., & García‐Viguera, C. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041679 · Cited by 560 · see citing works
Anthocyanins: from plant to health
de Pascual‐Teresa, S., & Sánchez-Ballesta, M. T. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9074-0 · Cited by 537 · see citing works
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1030064 · Cited by 489 · see citing works
“Xia et al. (2007) demonstrated that intracellular tumor necrosis factor receptor-associated factors’ (TRAFs) translocation to lipid rafts played pivotal role in CD40-mediated NF-kB activation, which induced inflammatory response in human endothelial cells.”
BackgroundAnthocyanins in Cardiovascular Disease
Wallace, T. C. (2011) · Advances in Nutrition · doi:10.3945/an.110.000042 · Cited by 474 · see citing works
Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
Krga, I., & Milenković, D. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06737 · Cited by 277 · see citing works
Regulation of anthocyanin biosynthesis in peach fruits
Rahim, A., Busatto, N., & Trainotti, L. (2014) · Planta · doi:10.1007/s00425-014-2078-2 · Cited by 269 · see citing works
Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review
Gonçalves, A. C., Nunes, A. R., Falcão, A. C., Alves, G., & Silva, L. R. (2021) · Pharmaceuticals · doi:10.3390/ph14070690 · Cited by 258 · see citing works
Proanthocyanidins, anthocyanins and cardiovascular diseases
Kruger, M. J., Davies, N. H., Myburgh, K. H., & Lecour, S. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.046 · Cited by 250 · see citing works
Guo, H., Xia, M., Zou, T., Ling, W., Zhong, R., & Zhang, W. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.12.013 · Cited by 221 · see citing works
Peterson, J. J., Dwyer, J. T., Jacques, P. F., & McCullough, M. L. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00508.x · Cited by 203 · see citing works
Woodward, G., Kroon, P. A., Cassidy, A., & Kay, C. D. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900602b · Cited by 198 · see citing works
The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
Kay, C. D., Kroon, P. A., & Cassidy, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800461 · Cited by 192 · see citing works
Effects of resveratrol and other wine polyphenols on vascular function: an update
Gresele, P., Cerletti, C., Guglielmini, G., Pignatelli, P., de Gaetano, G., & Violi, F. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.004 · Cited by 175 · see citing works
Red raspberry and its anthocyanins: Bioactivity beyond antioxidant capacity
Teng, H., Fang, T., Lin, Q., Song, H., Liu, B., & Chen, L. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.05.015 · Cited by 164 · see citing works
Amin, H., Czank, C., Raheem, S., Zhang, Q., Botting, N. P., Cassidy, A., & Kay, C. D. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400803 · Cited by 150 · see citing works
Metzger, B. T., Barnes, D. M., & Reed, J. D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073494t · Cited by 125 · see citing works
Guo, H., Ling, W., Wang, Q., Liu, C., Hu, Y., & Xia, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.11.016 · Cited by 121 · see citing works
Rub, A., Dey, R., Jadhav, M., Kamat, R. H., Chakkaramakkil, S., Majumdar, S., Mukhopadhyaya, R., & Saha, B. (2009) · Nature Immunology · doi:10.1038/ni.1705 · Cited by 117 · see citing works
Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art
Pagliaro, B., Santolamazza, C., Simonelli, F., & Rubattu, S. D. (2015) · BioMed Research International · doi:10.1155/2015/918069 · Cited by 115 · see citing works
Joven, J., Micol, V., Segura‐Carretero, A., Alonso‐Villaverde, C., Menéndez, J. A., & for the Bioactive Food Components, P. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.621772 · Cited by 114 · see citing works
Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases.
Janabi, A. H. W., Kamboh, A. A., Saeed, M., Lu, X., Bibi, J., Majeed, F., Naveed, M., Jameel, M., Korejo, N. A., Kamboh, R., et al. (2020) · PubMed Central · doi:10.22038/ijbms.2019.35125.8353 · Cited by 106 · see citing works
Barrajón‐Catalán, E., Herranz‐López, M., Joven, J., Segura‐Carretero, A., Alonso‐Villaverde, C., Menéndez, J. A., & Micol, V. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_11 · Cited by 106 · see citing works
Yang, Y., Shi, Z., Adili, R., Jin, J. W., Li, C., Wang, Y., Andrews, M. C., Chen, P., Zhu, G., Ling, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037323 · Cited by 99 · see citing works
Liu, Y., Yuan, Ž., Chen, H., Wang, D., Wang, M., Ou, J., & Xia, M. (2017) · Circulation · doi:10.1161/circulationaha.116.024503 · Cited by 96 · see citing works
Meng, G., Liu, Y., Lou, C.-C., & Yang, H. S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00993.x · Cited by 92 · see citing works
Bioavailability and molecular activities of anthocyanins as modulators of endothelial function
Speciale, A., Cimino, F., Saija, A., Canali, R., & Virgili, F. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0404-8 · Cited by 89 · see citing works
Gentile, D., Fornai, M., Pellegrini, C., Colucci, R., Blandizzi, C., & Antonioli, L. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000082 · Cited by 80 · see citing works
Uptake of grape anthocyanins into the rat kidney and the involvement of bilitranslocase
Vanzo, A., Terdoslavich, M., Brandoni, A., Torres, A. M., Vrhovšek, U., & Passamonti, S. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700505 · Cited by 72 · see citing works
The Molecular Basis for the Pharmacological Activity of Anthocyans
Domitrović, R. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797287601 · Cited by 70 · see citing works
Zou, J., Feng, D., Ling, W., & Duan, R. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.011 · Cited by 68 · see citing works
Yin, K., Chen, W., Zhou, Z., Zhao, G., Lv, Y.-C., Ouyang, X.-P., Yu, X.-H., Fu, Y., Jiang, Z., & Tang, C. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12823 · Cited by 62 · see citing works
Lipid rafts: A signalling platform linking lipoprotein metabolism to atherogenesis
Lemaire‐Ewing, S., Lagrost, L., & Néel, D. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.016 · Cited by 57 · see citing works
Targeting metabolic syndrome: Candidate natural agents
Xia, X., & Weng, J. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00090.x · Cited by 51 · see citing works
Olivares-Vicente, M., & Herranz-López, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178544 · Cited by 59 · see citing works
Song, Z., Jin, R., Yu, S., Rivet, J. J., Smyth, S. S., Nanda, A., Granger, D. N., & Li, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023239 · Cited by 44 · see citing works
Jayarathne, S., Stull, A. J., Miranda, A., Scoggin, S. O., Larson, K., Kim, J. H., & Moustaïd‐Moussa, N. (2018) · Nutrients · doi:10.3390/nu10111576 · Cited by 42 · see citing works
Rahim, A., Resentini, F., Vecchia, F. D., & Trainotti, L. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01143 · Cited by 40 · see citing works
Zhang, J., Wang, L., Gao, J., Xu, Y., Li, L., & Li, C. (2011) · Phytochemical Analysis · doi:10.1002/pca.1320 · Cited by 38 · see citing works
Linghu, K., Lin, D., Yang, H. S., Xu, Y., Zhang, Y., Tao, L., Chen, Y., & Shen, X. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.07.039 · Cited by 36 · see citing works
Aarsland, D., Khalifa, K., Bergland, A. K., Soennesyn, H., Oppedal, K., Holteng, L. B. A., Oesterhus, R., Nakling, A., Jarholm, J. A., de Lucia, C., et al. (2023) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.10.002 · Cited by 36 · see citing works
Sirijan, M., Pipattanawong, N., Saeng-on, B., & Chaiprasart, P. (2020) · Journal of Berry Research · doi:10.3233/jbr190487 · Cited by 35 · see citing works
Kabiri, N., Asgary, S., & Setorki, M. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-89 · Cited by 34 · see citing works
Łysiak, G. P. (2022) · Foods · doi:10.3390/foods11070948 · Cited by 33 · see citing works
Oyeyinka, B. O., & Afolayan, A. J. (2020) · Molecules · doi:10.3390/molecules25215036 · Cited by 28 · see citing works
Bergland, A. K., Soennesyn, H., Dalen, I., Rodriguez‐Mateos, A., Berge, R. K., Giil, L. M., Rajendran, L., Siow, R. C. M., Tassotti, M., Larsen, A. I., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00536 · Cited by 25 · see citing works
LeFevre, M. L., Wiles, J. E., Zhang, X., Howard, L. R., Gupta, S., Smith, A. A., Ju, Z. Y., & DeLany, J. P. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.005 · Cited by 24 · see citing works
Zhong, S. S., Yang, Y., Huo, J., Sun, Y., Zhao, H., Dong, X., Feng, J.-Y., Zhao, J., Wu, C., & Li, Y.-G. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109834 · Cited by 21 · see citing works
Khalifa, K. N., Bergland, A. K., Soennesyn, H., Oppedal, K., Oesterhus, R., Dalen, I., Larsen, A. I., Fladby, T., Brooker, H. J., Wesnes, K. A., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00916 · Cited by 21 · see citing works
Zhu, W., Xiong, L., Peng, J., Deng, X., Gao, J., & Li, C. (2016) · Scientific Reports · doi:10.1038/srep37680 · Cited by 20 · see citing works
Mahmoud, M. Y. (2013) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2013.665.672 · Cited by 18 · see citing works
XIA, M., Li, G., Ma, J., & Ling, W. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03683.x · Cited by 17 · see citing works
Inhibitory Effect of Carotenoids on Ligand-induced Lipid Raft Translocation of Immunoreceptors
Manabe, Y., Hirata, T., & Sugawara, T. (2019) · Journal of Oleo Science · doi:10.5650/jos.ess18204 · Cited by 16 · see citing works
Health-Promoting Effects of Wine Phenolics
Dávalos, A., & Lasunción, M. A. (2008) · Springer eBooks · doi:10.1007/978-0-387-74118-5_25 · Cited by 16 · see citing works
Hariri, M., Amirkalali, B., & Gholami, A. (2024) · Phytotherapy Research · doi:10.1002/ptr.8124 · Cited by 13 · see citing works
Protein Kinase C beta Mediates CD40 Ligand-Induced Adhesion of Monocytes to Endothelial Cells
Wu, Z., Zhao, G., Lin, P., Du, J., Wang, S., Huang, Y., Ou, J., & Jian, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072593 · Cited by 13 · see citing works
RetractedSeljåsen, R., Kristensen, H. L., Kretzschmar, U., Birlouez‐Aragon, I., Paoletti, F., Lauridsen, C., Wyss, G., Busscher, N., Mengheri, E., Sinesio, F., et al. (2015) · Organic Agriculture · doi:10.1007/s13165-015-0112-8 · Cited by 10 · see citing works
Chin, C. K., Stanly, C., Muniandy, A., Ramanathan, S., Murugaiyah, V., Chew, B. L., & Subramanıam, S. (2021) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-021-10159-3 · Cited by 9 · see citing works
Lipid rafts regulate cellular CD40 receptor localization in vascular endothelial cells
Xia, M., Wang, Q., Zhu, H., Ma, J., Hou, M., Tang, Z., Li, J., & Ling, W. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.102 · Cited by 9 · see citing works
Shahsavandi, S., Ebrahimi, M. M., & Farahani, A. H. (2017) · Europe PMC (PubMed Central) · Cited by 8 · see citing works
Liu, Y., Deng, G., Wang, X., Luo, J., Qian, X., & Ling, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104314 · Cited by 8 · see citing works
Anthocyanins in Vascular Diseases
Speciale, A., Virgili, F., Saija, A., & Cimino, F. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00072-4 · Cited by 8 · see citing works
Iranian traditional medicinal plants for management of chronic heart failure: A review
Keihanian, F., Moohebati, M., Saeidinia, A., & Mohajeri, S. A. (2023) · Medicine · doi:10.1097/md.0000000000033636 · Cited by 7 · see citing works
Acquisition, identification and analysis of an interspecificCapsicumhybrid (C. annuum × C. chinense)
Sui, Y. H., & Hui, N. B. (2015) · The Journal of Horticultural Science and Biotechnology · doi:10.1080/14620316.2015.11513150 · Cited by 7 · see citing works
de Pascual‐Teresa, S., Sánchez-Ballesta, M. T., & García‐Viguera, C. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_59 · Cited by 6 · see citing works
Metabolism of Anthocyanins and Modulation of Gut Microbiome in Inflammatory Bowel Disease
Alnadari, F., Abdin, M., Ennab, W., Ahmed, A. M. M., & Nasiru, M. M. (2020) · Journal of Food Chemistry and Nanotechnology · doi:10.17756/jfcn.2020-103 · Cited by 5 · see citing works
Kay, C. D., Kroon, P. A., & Cassidy, A. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108009828 · Cited by 4 · see citing works
Setiawan, M., & Nadhil, F. (2019) · Journal of Public Health in Africa · doi:10.4081/jphia.2019.1187 · Cited by 4 · see citing works
PHYTOTHERAPIES—PAST, PRESENT, AND FUTURE
Ramzan, I. M., & Li, G. Q. (2015) · doi:10.1002/9781119006039.ch1 · Cited by 4 · see citing works
The Modern Art of Atherosclerosis
Frolov, A., & Hui, D. Y. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000257134.75071.cb · Cited by 4 · see citing works
Sustainable Application of Flavonoid‐Based Natural Colorants
Salman, M., Adeel, S., Batool, F., Usama, M., Hassan, A., Özomay, M., & Hosseinnezhad, M. (2022) · doi:10.1002/9781119905332.ch15 · Cited by 4 · see citing works
Carrot Bisacetylenic Oxylipins – Phytochemicals Behind the Mask of the Superfood
Metzger, B. T. (2012) · ACS symposium series · doi:10.1021/bk-2012-1093.ch010 · Cited by 3 · see citing works
Dragano, N. R. V., & Marques, A. Y. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00011-7 · Cited by 3 · see citing works
Pharmacological profile of active phytometabolites from traditional medicinal plants
Nafees, S., Nafees, H., Nizamudeen, S., & Rather, R. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91883-1.00012-7 · Cited by 2 · see citing works
Wang, S., Xiong, F., Liu, Y., & Feng, Z. (2024) · Nutrition · doi:10.1016/j.nut.2024.112556 · Cited by 2 · see citing works
Immunoinflammatory effects of dietary bioactive compounds
Giampieri, F., Cianciosi, D., Ansary, J., Elexpuru-Zabaleta, M., Forbes-Hernández, T. Y., & Battino, M. A. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2020.12.001 · Cited by 2 · see citing works
Potent Beneficial Effects of Vegetables and Fruits on Cardiovascular Diseases
Nalini, N., & Santiago, J. V. A. (2013) · CRC Press eBooks · doi:10.1201/b14663-27 · Cited by 2 · see citing works
Perspectives of phytotherapeutics: Diagnosis and cure
Azmi, L., & Shukla, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824109-7.00010-8 · Cited by 1 · see citing works
Role of Anthocyanins in Neurological Disorders
Basheer, V. A., Maity, P., Sofalas, P. S., Vallinayagam, S., Ravi, S. N., & Packirisamy, A. S. B. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815223880124010013 · Cited by 1 · see citing works
Polyphenols: the hallmark of endothelial dysfunction combatants
Margina, D. M., Ungurianu, A., Purdel, C. N., Nițulescu, G., & Nițulescu, G. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85215-9.00040-4 · Cited by 1 · see citing works
Anthocyanins in metabolic health and disease
Overall, J., Lila, M. A., & Komarnytsky, S. (2017) · Wiley eBooks · doi:10.1002/9781119101277.ch5 · Cited by 1 · see citing works
Curtis, P. J., Kroon, P. A., Hollands, W. J., Walls, R. W., Kay, C. D., Jenkins, G., & Cassidy, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109992813
Genetic Engineering in Ornamental Plants
Dubey, R. K., Singh, P., Sidhu, P., & Dubey, M. (2013) · CRC Press eBooks · doi:10.1201/b16352-13
Jain, A., & Rani, V. (2016) · IGI Global eBooks · doi:10.4018/978-1-5225-1762-7.ch024
PROTECTIVE ROLE OF DIETARY BIOACTIVE COMPOUNDS: MECHANISMS AND HYPOTHESIS
Bonacina, G. (2010) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/bonacina-gaia_phd2010-12-17
Recent Advances in Temperate Fruit Crops
Rahim, A., & Trainotti, L. (2013) · CRC Press eBooks · doi:10.1201/b16352-9
Łysiak, G. P. (2021) · Preprints.org · doi:10.20944/preprints202110.0265.v1
Jain, A., & Rani, V. (2016) · Advances in environmental engineering and green technologies book series · doi:10.4018/978-1-5225-0591-4.ch001
Performance Benchmarking of Different Convolutional Neural Network Architectures on Covid-19 Dataset
Mishra, H. K., Singh, A., & Rastogi, A. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238846124010013
de Pascual‐Teresa, S., & Sánchez-Ballesta, M. T. (2025) · Springer eBooks · doi:10.1007/978-3-642-36202-6_59-1
- Authors
- Xia, M., Ling, W., Zhu, H., Wang, Q., Ma, J., Hou, M., Tang, Z., Li, L., & Ye, Q.
- Affiliations
- Sun Yat-sen University (CN)
- Venue
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2007-03
- Volume
- 27
- Issue
- 3
- Pages
- 519-524
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2074317596
- Cited by
- 96
- References
- 33
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- anthocyanins, CD40 signaling, TRAF2, lipid rafts, cholesterol distribution, NF-κB activation, endothelial inflammation, inflammatory cytokines, anti-inflammatory activity, CD40 ligand, siRNA knockdown
- MeSH terms
- Analysis of Variance, Anthocyanins, Arteriosclerosis, Cholesterol, Humans, Inflammation, Probability, Sensitivity and Specificity, Immunoblotting, Signal Transduction, CD40 Antigens, Endothelial Cells, TNF Receptor-Associated Factor 2
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