Cited by 160Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

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Influx in vivo of low density, intermediate density, and very low density lipoproteins into aortic intimas of genetically hyperlipidemic rabbits. Roles of plasma concentrations, extent of aortic lesion, and lipoprotein particle size as determinants.

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Nordestgaard, B G, Tybjaerg-Hansen, A, Lewis, B·1992·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

DOI 10.1161/01.atv.12.1.6

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Abstract

To compare the atherogenic potential of low density lipoprotein (LDL), intermediate density lipoprotein (IDL), and very low density lipoprotein (VLDL) under conditions where plasma levels of these lipoproteins are elevated, the influx of cholesterol in these lipoproteins into the aortic intima was measured in vivo in genetically hyperlipidemic rabbits from the St. Thomas's Hospital strain, an animal model that shares many of the features of the human disorder familial combined hyperlipidemia. Univariate linear regression showed that the arterial influx of LDL cholesterol (n = 25), IDL cholesterol (n = 14), and VLDL cholesterol (n = 10) was positively and linearly associated with plasma concentrations of LDL cholesterol in the range 0.2-6.4 mmol/l, of IDL cholesterol in the range 0.1-7.0 mmol/l, and of VLDL cholesterol in the range 0.7-8.5 mmol/l, respectively, and also with the extent of lesions in the arterial intima in the range 0-100% of the surface area. Multiple linear regression suggested that the arterial influx of LDL, IDL, and VLDL cholesterol was linearly dependent on plasma concentration, independent of lesion size. Furthermore, it appeared that the arterial influx of the three lipoproteins was linearly dependent on the extent of the lesions, independent of lipoprotein concentration. When influx was normalized for plasma concentration (intimal clearance) and for lesion size (compared within the same aorta), the intimal clearance of the larger IDL and VLDL particles was 15-35% less than that of the smaller LDL particles. These findings suggest that the quantitatively most important mechanism for transfer of plasma lipoproteins into the arterial intima involves nonspecific molecular sieving and that at elevated plasma levels, IDL and VLDL share with LDL the potential for causing atherosclerosis.

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Efficient Trace-labelling of Proteins with Iodine
McFarlane, A. S. (1958) · Nature · doi:10.1038/182053a0 · Cited by 2,559
The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,815
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA
Goldstein, J. L., Schrott, H. G., Hazzard, W. R., Bierman, E. L., & Motulsky, A. G. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107332 · Cited by 1,444
[1] Introduction to the plasma lipoproteins
Gotto, A. M., Pownall, H. J., & Havel, R. J. (1986) · Methods in Enzymology · doi:10.1016/0076-6879(86)28061-1 · Cited by 421
Enhanced macrophage uptake of low density lipoprotein after self-aggregation.
Khoo, J. C., Miller, E. R., McLoughlin, P., & Steinberg, D. H. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.4.348 · Cited by 367
FAMILY STUDY OF SERUM LIPIDS AND LIPOPROTEINS IN CORONARY HEART-DISEASE
Nikkilä, E., & Aro, A. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91598-5 · Cited by 291
Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions.
Schwenke, D. C., & Carew, T. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.895 · Cited by 272
INTERMEDIATE-DENSITY LIPOPROTEINS AND PROGRESSION OF CORONARY ARTERY DISEASE IN HYPERCHOLESTEROLAEMIC MEN
Krauss, R., Williams, P. T., Brensike, J. F., Detre, K. M., Lindgren, F. T., Kelsey, S. F., VRANIZAN, K. M., & Levy, R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92734-6 · Cited by 256
Kinetic bases of the primar hperlipidaemias: studies of apolipoprotein B turnover in geneticall defined subjects
Janus, E. D., Nicoll, A. D., TURNER, P. R., MAGILL, P., & Lewis, B. (1980) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1980.tb02076.x · Cited by 248
Self-citation
Increased Lipoprotein-Remnant Formation in Chronic Renal Failure
Nestel, P. J., Fidge, N., & Tan, M. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198208053070601 · Cited by 240

Show all 37 references

Research works printed but not linked: 11

Grundy SM, Chait A, Brunzell JD: Familial combined hyper- lipidemia workshop. Arteriosclerosis 1987;7:203-207
Janus ED, Nicoll AM, Turner PR, Magill P, Lewis B: Kinetic bases of the primary hyperlipidaemias: Studies of apolipopro- tein B turnover in genetically defined subjects. Eurl Clin Invest 1980;10:161-172
Tatami R, Mabuchi H, Ueda K, Ueda R, Hara T, Kametani T, Ito S, Koizumi J, Ohta M, Miyamoto S, Nakayama A, Kanaya H, Oiwake H, Genda A, Takeda R: Intermediate-density lipoprotein and cholesterol-rich very low density lipoprotein in angiographically determined coronary artery disease. Circula- tion 1981;64:1174-1184
Reardon MF, Nestel PJ, Craig IH, Harper RW: Lipoprotein predictors of the severity of coronary artery disease in men and women. Circulation 1985;71:881-888
Steiner G, Schwartz L, Shumak S, Poapst M: The association of increased levels of intermediate-density lipoproteins with smoking and with coronary artery disease. Circulation 1987;75: 124-130
Ryan BF, Joiner BL, Ryan TA Jr: MINITAB Handbook, ed 2. Boston, Duxbury Press, 1985, pp 218-259
Forte TM, Nordhausen RW: Electron microscopy of nega- tively stained lipoproteins. Methods Enzymol 1986;128: 442-457
Newman HAI, Zilversmit DB: Uptake and release of choles- terol by rabbit atheromatous lesions. Ore Res 1966;18:293-302
Stender S, Zilversmit DB: Arterial influx of esterified choles- terol from two plasma lipoprotein fractions and its hydrolysis in vivo in hypercholesterolemic rabbits. Atherosclerosis 1981; 39:97-109
Brown MS, Goldstein JL, Fredrickson DS: Familial type 3 hyperlipidemia (dysbetalipoproteinemia), in Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds): The Metabolic Basis of Inherited Disease, ed 5. New York, McGraw-Hill Book Co, Inc, 1983, pp 655-671
NikkilS EA: Familial lipoprotein lipase deficiency and related disorders of chylomicron metabolism, in Stanbury JB, Wyn- gaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds): The Metabolic Basis of Inherited Disease, ed 5. New York, McGraw-Hill Book Co, Inc, 1983, pp 622-642

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Goldberg, I. J., Kako, Y., & Lutz, E. P. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200006000-00003 · Cited by 46
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Kreuzer, J., Lloyd, M. B., Bok, D., Fless, G. M., Scanu, A. M., Lusis, A. J., & Haberland, M. E. (1994) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(94)90137-6 · Cited by 45
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Authors: Nordestgaard, B. G., Tybjaerg-Hansen, A., & Lewis, B.
Affiliations: St Thomas' Hospital (GB)
Department of Chemical Pathology and Metabolic Disorders, United Medical School, St. Thomas's Hospital, London, UK.
ORCID: Nordestgaard, B G
Lewis, B
Venue: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-01
Volume: 12
Issue: 1
Pages: 6-18
ISSN: 1049-8834 (ISSN-L)
DOI: 10.1161/01.atv.12.1.6
OpenAlex: W2067328467
Cited by: 159
References: 37
Citations by year: 2026: 5 · 2025: 11 · 2024: 7 · 2023: 14 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 3
FWCI: 6.36
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Hjerteforeningen
Sundhed og Sygdom, Det Frie Forskningsråd
Wellcome Trust
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: low-density lipoprotein, intermediate density lipoprotein, VLDL, aortic intima, atherosclerosis, familial combined hyperlipidemia, lipoprotein particle size, molecular sieving, cholesterol transfer, atherogenic potential
MeSH terms: Animals, Aorta, Cholesterol, Female, Hyperlipidemia, Familial Combined, Lipoproteins, Cholesterol, LDL, Male, Microscopy, Electron, Rabbits, Regression Analysis, Cholesterol, VLDL

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Influx in vivo of low density, intermediate density, and very low density lipoproteins into aortic intimas of genetically hyperlipidemic rabbits. Roles of plasma concentrations, extent of aortic lesion, and lipoprotein particle size as determinants.

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