Cited by 143Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Quantification of Postprandial Triglyceride-Rich Lipoproteins in Healthy Men by Retinyl Ester Labeling and Simultaneous Measurement of Apolipoproteins B-48 and B-100

Open access

Karpe, Fredrik, Bell, Max, Björkegren, Johan, Hamsten, Anders·1995·Arteriosclerosis, Thrombosis, and Vascular Biology

Open this paper in CoChat — free account Open PDF

Abstract

Abstract The metabolism of chylomicrons, very-low-density lipoprotein (VLDL), and their remnants in the postprandial state was studied in normolipidemic healthy men by measuring apoB-48 and apoB-100 and retinyl palmitate (RP) in fractions of triglyceride-rich lipoproteins after a mixed meal type of oral fat load supplemented with vitamin A. ApoB-48 was present at low concentrations in the fasting plasma samples in most subjects and increased in response to the test meal in Svedberg’s flotation rate (Sf) >20 lipoprotein fractions. Concomitantly, the level of Sf 60 to 400 apoB-100 (large VLDL) had doubled at 3 hours and returned to baseline at 9 hours. The number of apoB-48–containing lipoprotein particles did not exceed 20% of the total number of apoB-containing lipoproteins contained in Sf 12 to 400 fractions at any time point after fat intake. The peak plasma level of RP was delayed compared with the peak plasma concentration of apoB-48, suggesting that retinyl ester labeling of chylomicrons is questionable as a means of quantifying postprandial triglyceride-rich lipoproteins of intestinal origin. Approximately 2000 and 4000 RP molecules were carried in each chylomicron particle in the 3- and 6-hour samples, respectively, in contrast to the remnant fractions in which 100 to 600 RP molecules were found for each lipoprotein particle. The limited RP exchange between lipoprotein particles indicates that the smaller intestinal lipoproteins do no originate primarily from larger Sf >400 chylomicron particles but instead are secreted directly into the Sf 20 to 400 fraction and subsequently converted to smaller chylomicron remnants. This notion was further substantiated by injection of RP-labeled postprandial plasma into fasting subjects with subsequent tracing of RP in fractions of triglyceride-rich lipoproteins.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.15.2.199

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
A new method for the direct determination of serum cholesterol.
Zlatkis, A., Zak, B., & Boyle, A. J. (1953) · PubMed · Cited by 2,467
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
A colorimetric method for estimating serum triglycerides
Fletcher, M. J. (1968) · Clinica Chimica Acta · doi:10.1016/0009-8981(68)90041-7 · Cited by 1,133
Plasma triglyceride and coronary heart disease
Austin, M. A. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.2 · Cited by 697
Determination of serum triglycerides
Carlson, L. A. (1963) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(63)80012-5 · Cited by 694
Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man
Brunzell, J. D., Hazzard, W. R., Porte, D., & Bierman, E. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107334 · Cited by 484
Lipoprotein fractionation.
Carlson, K. (1973) · Journal of Clinical Pathology · doi:10.1136/jcp.s1-5.1.32 · Cited by 420
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
Weintraub, M. S., Eisenberg, S., & Breslow, J. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113243 · Cited by 418
Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 10

10.1161/circ.60.3.222498 · DOI
1980, Fed Proc, 39, 2716
1990, J Clin Invest, 88, 985
10.1161/atv91.13.6.8499400 · DOI
Diem K Lentner C eds. Documenta Geigy . 7th ed. Basel Switzerland: JR Geigy SA; 1970:537.
1953, J Lab Clin Med, 41, 486
Snedecor GW Cochran WG. Statistical Methods . 7th ed. Ames Iowa: Iowa State University Press; 1980.
1994, J Biol Chem, 369, 16559
1981, J Lab Clin Med, 97, 449
10.1161/atv91.11.1.1987999 · DOI

Sorted by citations

Items 101–143 of 143

Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity
van Beek, A. P., van Barlingen, H. H. J. J., de Ruijter-Heijstek, F. C., Jansen, H., Erkelens, D. W., Dallinga‐Thie, G. M., & de Bruin, T. W. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33894-3 · Cited by 22
Early alterations in the postprandial VLDL1 apoB‐100 and apoB‐48 metabolism in men with strong heredity for type 2 diabetes
Johanson, E. H., Jansson, P., Gustafson, B., Lönn, L., Smith, U., Taskinen, M., & Axelsen, M. (2004) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01281.x · Cited by 22
Comparison of three fatty meals in healthy normolipidaemic men: high post‐prandial retinyl ester response to soybean oil
Mero, Syvänne, Rosseneu, Labeur, Hilden, & Taskinen, M. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00309.x · Cited by 21
Metabolism of Triglyceride-Rich Lipoproteins
Borén, J., & Taskinen, M. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_520 · Cited by 22
Hypertriglyceridemia and Atherosclerotic Carotid Artery Stenosis
Miura, Y., & Suzuki, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416224 · Cited by 21
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
Zorn, S., Bounds, R., Williamson, A., Lawler, K., Hanßen, R., Keogh, J. M., Henning, E., Smith, M., Fielding, B. A., Umpleby, A. M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03976-1 · Cited by 19
Postprandial Dyslipidemia: A Risk Factor for Coronary Heart Disease
Dallongeville, J., & Fruchart, J. (1998) · Annals of Nutrition and Metabolism · doi:10.1159/000012712 · Cited by 19
Delayed Changes in Postprandial Lipid in Young Normolipidemic Men after a Nocturnal Vitamin A Oral Fat Load Test
Hadjadj, S., Paul, J., Meyer, L., Durlach, V., Vergès, B. L., Ziegler, O., Drouin, P., & Guerci, B. (1999) · Journal of Nutrition · doi:10.1093/jn/129.9.1649 · Cited by 19
Baseline Very Low-Density Lipoprotein Cholesterol is Associated with the Magnitude of Triglyceride Lowering on Statins, Fenofibric Acid, or Their Combination in Patients with Mixed Dyslipidemia
Sharma, A., Joshi, P. H., Rinehart, S. J., Thakker, K. M., Lele, A., & Vörös, S. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9559-3 · Cited by 18
Postprandial hyperlipidemia as a risk factor in patients with type 2 diabetes
Tomlinson, B., Chan, P., & Lam, C. W. K. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1750949 · Cited by 20
Impaired postprandial clearance of squalene and apolipoprotein B-48 in post-menopausal women with coronary artery disease
Rajaratnam, R., Gylling, H., & Miettinen, T. A. (1999) · Clinical Science · doi:10.1042/cs0970183 · Cited by 17
LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease
Sposito, A. C., Santos, R. D., Hueb, W. A., Ventura, L. I., Vinagre, C. G. C., Ramires, J. A. F., & Maranhão, R. C. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00661-x · Cited by 17
Isolation of remnant particles by immunoseparation: a new approach for investigation of postprandial lipoprotein metabolism in normolipidemic subjects
Schreuder, P. C. N. J., Twickler, T. B., Wang, T., Nakajima, K., Erkelens, D. W., & Dallinga‐Thie, G. M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00666-3 · Cited by 16
Separation and quantification of apolipoprotein B-48 and other apolipoproteins by dynamic sieving capillary electrophoresis
Proctor, S. D., & Mamo, J. C. L. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37452-6 · Cited by 15
Role of HDL in neutralizing the VLDL effect on endothelial dysfunction
Zago, V., Gorzalczany, S. B., Lucero, D., Taira, C. A., & Schreier, L. E. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.06.002 · Cited by 13
Use of water-miscible retinyl palmitate as markers of chylomicrons gives earlier peak response of plasma retinyl esters compared with oil-soluble retinyl palmitate
Renuka, K. D., Silva, R., Williams, C. M., & Lovegrove, J. A. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001433 · Cited by 12
The direct way from gut to vessel wall: Atheroinitiation
Cabezas, C., & Erkelens (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00318.x · Cited by 11
No acute effect of nateglinide on postprandial lipid and lipoprotein responses in subjects at risk for type 2 diabetes
Johanson, E. H., Jansson, P., Gustafson, B., Sandqvist, M., Taskinen, M., Smith, U., & Axelsen, M. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.542 · Cited by 12
Dietary fat and physiological determinants of plasma chylomicron remnant homoeostasis in normolipidaemic subjects: insight into atherogenic risk
Irawati, D., Mamo, J. C. L., Clark, K., Soares, M. J., & James, A. P. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000150 · Cited by 10
Chylomicron processing in familial dysbetalipoproteinemia and familial combined hyperlipidemia studied with vitamin A and E as markers: a new physiological concept
Demacker, P. N. M., Hectors, M. P. C., & Stalenhoef, A. F. H. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00326-3 · Cited by 10
Intermediate-density lipoproteins, diabetes and coronary artery disease
Steiner, G. A. (1998) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(98)00040-0 · Cited by 8
Influence of apolipoprotein-E phenotypes on postprandial lipoprotein metabolism after three different fat loads
Fernández‐Miranda, C., Cancelas, P., Sanz, M., Porres, A., & Gerique, J. G. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00552-4 · Cited by 8
Hypertriglyceridemic subjects exhibit an accumulation of small dense chylomicron particles in the fasting state
Irawati, D., Mamo, J. C. L., Soares, M. J., Clark, K., & James, A. P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.018 · Cited by 6
Triglycerides and Cardiovascular Disease : A Scientific Statement From the
Pennathur, S., Kris‐Etherton, P. M., Lennie, T. A., Levi, M., Mazzone, T., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Stone, N. J., Ballantyne, C. M., et al. (2011) · Cited by 6
Preventing, stopping, or reversing coronary artery disease— triglyceride-rich lipoproteins and associated lipoprotein and metabolic abnormalities: The need for recognition and treatment
Ferguson, E. E. (2000) · Disease-a-Month · doi:10.1016/s0011-5029(00)90011-7 · Cited by 6
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159 → Arg) and low HDL cholesterol level without coronary artery disease
Gylling, H. K., Relas, H., Miettinen, H. E., Radhakrishnan, R., & Miettinen, T. A. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05961-8 · Cited by 6
Postprandial lipemia and the relationship to health
Huggins, C. E., James, A. P., Bonham, M. P., Clark, K., & Lee, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823914-8.00019-7 · Cited by 3
Phospholipase D mediates very low-density lipoprotein-induced aldosterone production, in part, via lipin-1
Spaulding, S. C., Choudhary, V., & Bollag, W. B. (2023) · Journal of Molecular Endocrinology · doi:10.1530/jme-22-0196 · Cited by 3
Production and Metabolism of Triglyceride-Rich Lipoproteins in Both the Normal and Diabetic States
Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Contemporary diabetes · doi:10.1007/978-1-4614-7554-5_6 · Cited by 3
Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women
Kuzawa, K., Morita, Y., Ichikawa, N., & Naito, M. (2021) · Journal of Food and Nutrition Sciences · doi:10.11648/j.jfns.20210906.13 · Cited by 2
Apolipopretein A-I and B Distribution among the Employees and their Partners in Korea
Kim, W. S., Kim, D. I., & Suh, B. S. (2007) · Journal of Preventive Medicine and Public Health · doi:10.3961/jpmph.2007.40.1.71 · Cited by 2
Hypertriglyceridemia and Non-Alcoholic Fatty Liver Disease in Metabolic Syndrome and Type 2 Diabetes
Tangvarasittichai, S. (2018) · Diabetes & Obesity International Journal · doi:10.23880/doij-16000188 · Cited by 2
An improved method for the rapid assessment of persisting chylomicron remnant concentrations
Orth, M., Weinland-Wilken, C., Westphal, S., & Luley, C. H. (2001) · Clinical Biochemistry · doi:10.1016/s0009-9120(01)00233-8 · Cited by 2
Production and Metabolism of Triglyceride-Rich Lipoproteins: Impact of Diabetes
Pirillo, A., Norata, G. D., & Catapano, A. L. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-26681-2_7 · Cited by 3
Efecto agudo de orlistat la lipemia posprandial
Cintora, H., González, C. D., Machain, M. G., Cintora, F. M., & Montero, J. (2003) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(03)78912-8
Metabolismo dos quilomícrons e capacidade da lipoproteína de alta densidade (HDL) de receber lípides na síndrome metabólica e no diabetes mellitus tipo 2
da Silva, V. M. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2008.tde-04042008-155832
Metabolismo de quilomícrons e aterosclerose subclínica em portadores de hipercolesterolemia familiar heterozigótica
Carneiro, M. M. (2011) · doi:10.11606/t.5.2011.tde-23112011-192759
Relação da lipemia pós prandial com aterosclerose avaliada pela angiotomografia coronária
de Cardiologia, P. (2013)
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American
Lennie, T. A., Levi, M., Mazzone, T., Pennathur, S., Goldberg, A. C., Howard, W. J., Jacobson, M. Z., Stone, N. J., Ballantyne, C. M., Bittner, V., et al. (2013)
Investigation on postprandial triglyceride and remnant-like particle cholesterol levels after low-fat meal ingestion in the Japanese population
Moriyama, K., Masuda, Y., Suzuki, N., Yamada, C., Kishimoto, N., Takashimizu, S., Akira, K. U. B. O., & Nishizaki, Y. (2022) · Health Evaluation and Promotion · doi:10.7143/jhep.2022-20
Factors associated with postprandial hypertriglyceridemia and carotid atherosclerosis in patients with type 2 diabetes mellitus
Juvvadi, R., Reddy, K. S., & Reddy, K. S. (2024) · MRIMS Journal of Health Sciences · doi:10.4103/mjhs.mjhs_44_24
Impact of serum squalene, postprandial lipoproteins, and cholesterol metabolism on coronary artery disease in postmenopausal women
Rajaratnam, R. (2000) · Työväentutkimus Vuosikirja
Postprandial Inflammatory Stress: A Hypothesis-Generating Framework Linking Metabolic, Immune and Vascular Responses
Šantić, R., Kumrić, M., Martinovic, L., Pavlović, N., Rizikalo, A., Vilović, M., Vrdoljak, J., & Božić, J. (2026) · Life · doi:10.3390/life16081298

Authors: Karpe, F., Bell, M., Björkegren, J., & Hamsten, A.
Affiliations: Karolinska University Hospital (SE)
From the Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
ORCID: Karpe, Fredrik
Bell, Max
Hamsten, Anders
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1995-02
Volume: 15
Issue: 2
Pages: 199-207
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.15.2.199
OpenAlex: W2107863042
Cited by: 143
References: 30
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 9.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Hjärt-Lungfonden
Marcus och Amalia Wallenbergs minnesfond
Medical Research Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: postprandial lipemia, triglyceride-rich lipoproteins, chylomicrons, VLDL, apolipoprotein B-48, apolipoprotein B-100, chylomicron remnants, vitamin A, lipoprotein metabolism
MeSH terms: Retinyl Esters, Adult, Apolipoproteins B, Chylomicrons, Dietary Fats, Diterpenes, Eating, Fasting, Humans, Male, Triglycerides, Vitamin A, Apolipoprotein B-48, Apolipoprotein B-100

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quantification of Postprandial Triglyceride-Rich Lipoproteins in Healthy Men by Retinyl Ester Labeling and Simultaneous Measurement of Apolipoproteins B-48 and B-100

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks