Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.

Weintraub, M S; Zechner, R; Brown, A; Eisenberg, S; Breslow, J L

doi:10.1172/jci113806

Cited by 331Fatty Acid Research and HealthLipid metabolism and disordersLipid metabolism and biosynthesis

Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.

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Weintraub, M S, Zechner, R, Brown, A, Eisenberg, S, Breslow, J L·1988·Journal of Clinical Investigation

DOI 10.1172/jci113806PMC PMC442768

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Abstract

The chronic and acute effects of different types of dietary fat on postprandial lipoprotein metabolism were studied in eight normolipidemic subjects. Each person was placed for 25 d on each of three isocaloric diets: a saturated fat (SFA), a w-6 polyunsaturated fat (w-6 PUFA) and a w-3 polyunsaturated fat (w-3 PUFA) diet. Two vitamin A-fat loading tests were done on each diet. The concentrations in total plasma and chylomicron (Sf greater than 1,000) and nonchylomicron (Sf less than 1,000) fractions of retinyl palmitate (RP) were measured for 12 h postprandially. Compared with the SFA diet, the w-6 PUFA diet reduced chylomicron and nonchylomicron RP levels 56 and 38%, respectively, and the w-3 PUFA diet reduced these levels 67 and 53%, respectively. On further analysis, the main determinant of postprandial lipoprotein levels was the type of fat that was chronically fed, which appeared to mediate its effect by changing the concentration of the endogenous competitor for the system that catabolizes triglyeride-rich lipoproteins. However, there was a significant effect of the acute dietary fat load, which appeared to be due to a differential susceptibility to lipolysis of chylomicrons produced by SFA as opposed to PUFA fat loads. The levels of postprandial lipoproteins are determined by the interaction of these chronic and acute effects.

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Fish oil supplementation lowers fasting and postprandial TG concentrations.
“Fish oil supplementation lowers not only fasting (17) but also postprandial TG concentrations, regardless of the nature of the fat in the test meal (6,8,11,12,28,29).”
From Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance (2003) · cites this paper as [12]
Both acute and chronic supplementation with OM3FAs reduced plasma levels of chylomicrons and postprandial TG levels to a greater extent than saturated fatty acid- or OM6FA-enriched meals.
“It showed that both acute and chronic supplementation with OM3FAs reduced plasma levels of chylomicrons and postprandial TG levels to a greater extent than saturated fatty acid- or OM6FA-enriched meals.”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [37]

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Applied Regression Analysis and Other Multivariable Methods
Walker, E., Kleinbaum, D. G., Kupper, L. L., & Muller, K. E. (1989) · Technometrics · doi:10.2307/1270375 · Cited by 8,538 · see citing works
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177 · see citing works
Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol.
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,171 · see citing works
Applied Regression Analysis and Other Multivariable Methods.
Bhattacharyya, H. T., Kleinbaum, D. G., & Kupper, L. L. (1979) · Journal of the American Statistical Association · doi:10.2307/2287012 · Cited by 1,767 · see citing works
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701 · see citing works
CLEARING FACTOR, A HEPARIN-ACTIVATED LIPOPROTEIN LIPASE
Korn, E. D. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66011-9 · Cited by 858 · see citing works
Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia
Phillipson, B. E., Rothrock, D. W., We, C., Harris, W., & Illingworth, D. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121902 · Cited by 847 · see citing works
THE INFLUENCE OF DIETARY FATS ON SERUM-LIPID LEVELS IN MAN
Ahrens, E., Insull, W., Blomstrand, R., Hirsch, J., Tsaltas, T. T., & Peterson, M. L. (1957) · The Lancet · doi:10.1016/s0140-6736(57)91280-1 · Cited by 726 · see citing works
Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.
Goodnight, S. H., Harris, W. S., We, C., & Illingworth, D. R. (1982) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.2.2.87 · Cited by 678 · see citing works
An easy colorimetric micromethod for routine determination of free fatty acids in plasma
Falholt, K., Lund, B., & FALHOLT, W. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90016-8 · Cited by 636 · see citing works
Suppression by diets rich in fish oil of very low density lipoprotein production in man.
Nestel, P. J., CONNOR, W. E., Reardon, M., Connor, S. L., Wong, S., & Boston, R. C. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111422 · Cited by 616 · see citing works
Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
von Schacky, C., Fischer, S., & Weber, C. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112147 · Cited by 613 · see citing works
A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis
DAYTON, S., PEARCE, M. L., HASHIMOTO, S., DIXON, W. J., & TOMIYASU, U. (1969) · Circulation · doi:10.1161/01.cir.40.1s2.ii-1 · Cited by 595 · cited 2× · see citing works
“Fraction (3,068) (3,208) (1,494) (1,790) (1,372) (2,008)”
Background
PLASMA LIPIDS AND LIPOPROTEINS IN GREENLANDIC WEST COAST ESKIMOS
Bang, H. O., & Dyerberg, J. (1972) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1972.tb04782.x · Cited by 566 · see citing works
EFFECT OF CHOLESTEROL-LOWERING DIET ON MORTALITY FROM CORONARY HEART-DISEASE AND OTHER CAUSES
Miettinen, M., Karvonen, M. J., Turpeinen, O., Elosuo, R., & Paavilainen, E. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92208-8 · Cited by 500 · see citing works
Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons
Redgrave, T. G. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106255 · Cited by 498 · see citing works
Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man
Brunzell, J. D., Hazzard, W. R., Porte, D., & Bierman, E. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107334 · Cited by 484 · see citing works
Effects of Dietary Polyunsaturated and Saturated Fat on the Properties of High Density Lipoproteins and the Metabolism of Apolipoprotein A-I
Shepherd, J., Packard, C. J., Patsch, J. R., Gotto, A. M., & Taunton, O. D. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109078 · Cited by 456 · see citing works
Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia
Krauss, R. M., Levy, R. I., & Fredrickson, D. S. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107855 · Cited by 436 · see citing works
The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: Salmon oil versus vegetable oils
Harris, W. S., Connor, W. E., & McMurry, M. P. (1983) · Metabolism · doi:10.1016/0026-0495(83)90226-3 · Cited by 422 · see citing works
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
Weintraub, M. S., Eisenberg, S., & Breslow, J. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113243 · Cited by 418 · see citing works
Self-citation
The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study
Goodnight, S. J., Harris, W., & We, C. (1981) · Blood · doi:10.1182/blood.v58.5.880.880 · Cited by 405 · see citing works
Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69254-9 · Cited by 383 · see citing works
Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
Mahley, R. W., Hui, D. Y., Innerarity, T. L., & Weisgraber, K. H. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110365 · Cited by 375 · see citing works
Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.
Windler, E., Chao, Y., & Havel, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70647-4 · Cited by 365 · see citing works
Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man.
Shepherd, J., Packard, C. J., Grundy, S. M., Yeshurun, D., Gotto, A. M., & Taunton, O. D. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39842-4 · Cited by 357 · see citing works
Effect on Blood Lipids and Haemostasis of a Supplement of Cod-Liver Oil, Rich in Eicosapentaenoic and Docosahexaenoic Acids, in Healthy Young Men
Sanders, T. A. B., Vickers, M. V., & Haines, A. (1981) · Clinical Science · doi:10.1042/cs0610317 · Cited by 351 · see citing works
Particulate Fat in Lymph and Blood
Dole, V. P., & Hamlin, J. T. (1962) · Physiological Reviews · doi:10.1152/physrev.1962.42.4.674 · Cited by 315 · see citing works
The Influence of Different Types of ω3 Polyunsaturated Fatty Acids on Blood Lipids and Platelet Function in Healthy Volunteers
Sanders, T. A. B., & Roshanai, F. (1983) · Clinical Science · doi:10.1042/cs0640091 · Cited by 309 · see citing works
Conversion of very low density lipoprotein to low density lipoprotein. A metabolic study of apolipoprotein B kinetics in human subjects.
Sigurdsson, G. T., Nicoll, A. D., & Lewis, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108229 · Cited by 308 · see citing works
Lipid Metabolism and Ischemic Heart Disease in Greenland Eskimos
Bang, H. O., & Dyerberg, J. (1980) · Springer eBooks · doi:10.1007/978-1-4757-4448-4_1 · Cited by 304 · see citing works
Metabolic relationships among the plasma lipoproteins
Wilson, D. E., & Lees, R. S. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106896 · Cited by 290 · see citing works
Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition
Connor, W. E., Witiak, D. T., Stone, D. B., & Armstrong, M. L. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106102 · Cited by 279 · see citing works
Effects of dietary fats on plasma lipids and lipoproteins: an hypothesis for the lipid-lowering effect of unsaturated fatty acids
Spritz, N., & Mishkel, M. A. (1969) · Journal of Clinical Investigation · doi:10.1172/jci105976 · Cited by 274 · see citing works
The effect of a fish diet on serum lipids in healthy human subjects
von Lossonczy, T., Ruiter, A., Bronsgeest-Schoute, H. C., van Gent, C., & Hermus, R. J. J. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.8.1340 · Cited by 270 · see citing works
The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man
Grundy, S. M., & AHRENS, E. H. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106329 · Cited by 262 · see citing works
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.
Weintraub, M. S., Eisenberg, S., & Breslow, J. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112926 · Cited by 261 · see citing works
Self-citation
Relationship between Plasma Triglycerides and Removal of Chylomicrons*
Nestel, P. J. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104980 · Cited by 261 · see citing works
The biochemical, clinical, and genetic features of type III hyperlipoproteinemia.
MORGANROTH, J., LEVY, R. I., & FREDRICKSON, D. S. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-82-2-158 · Cited by 260 · see citing works
Postprandial lipemia. A key for the conversion of high density lipoprotein2 into high density lipoprotein3 by hepatic lipase.
Patsch, J. R., Prasad, S. C., Gotto, A. M., & Bengtsson-Olivecrona, G. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111624 · Cited by 256 · see citing works
Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans.
Illingworth, D. R., Harris, W. S., & CONNOR, W. E. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.3.270 · Cited by 255 · see citing works
THE METABOLISM OF CHYLOMICRON CHOLESTEROL ESTER IN THE RAT
Goodman, D. S. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104645 · Cited by 243 · see citing works
Chylomicron clearance in normal and hyperlipidemic man
Grundy, S. M., & Mok, H. Y. I. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80006-6 · Cited by 218 · see citing works
Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.
Sanders, T. A., Sullivan, D. R., Reeve, J., & Thompson, G. R. (1985) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.5.5.459 · Cited by 212 · see citing works
Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells.
Blomhoff, R., Rasmussen, M., Nilsson, A. C., Norum, K. R., Berg, T., Blaner, W. S., Kato, M., Mertz, J. R., Goodman, D. S., & Eriksson, U. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38759-8 · Cited by 211 · see citing works
New micromethod for measuring cholesterol in plasma lipoprotein fractions.
Bronzert, T. J., & Brewer, H. B. (1977) · Clinical Chemistry · doi:10.1093/clinchem/23.11.2089 · Cited by 211 · see citing works
SITES OF LIPOPROTEIN LIPASE ACTIVITY IN ADIPOSE TISSUE PERFUSED WITH CHYLOMICRONS
Blanchette‐Mackie, E. J., & Scow, R. O. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.51.1.1 · Cited by 170 · see citing works
Delayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-β disease (type III hyperlipoproteinemia)
Hazzard, W. R., & Bierman, E. L. (1976) · Metabolism · doi:10.1016/0026-0495(76)90149-9 · Cited by 169 · see citing works
The anti-coronary club. A dietary approach to the prevention of coronary heart disease--a seven-year report.
Christakis, G., Rinzler, S. H., Archer, M., Winslow, G., Jampel, S., Stephenson, J., Friedman, G. H., Fein, H. G., Kraus, A., & James, G. (1966) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.56.2.299 · Cited by 142 · see citing works
Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects.
Berr, F., & Kern, F. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37744-0 · Cited by 132 · see citing works
Kinetics of chylomicron remnant clearance in normal and in hyperlipoproteinemic subjects.
Cortner, J. A., Coates, P. M., Le, N., Cryer, D. R., Ragni, M. C., Faulkner, A., & Langer, T. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38721-6 · Cited by 125 · see citing works
Effect of changing dietary fat saturation on low-density lipoprotein metabolism in man
Turner, J. D., Le, N., & Brown, W. V. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.241.1.e57 · Cited by 124 · see citing works
Relationships between the metabolism of high‐density and very‐low‐density lipoproteins in man: studies of apolipoprotein kinetics and adipose tissue lipoprotein lipase activity
MAGILL, P., Rao, S. N., Miller, N. E., Nicoll, A., Brunzell, J., Hilaire, J., & Lewis, B. (1982) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1982.tb00947.x · Cited by 122 · see citing works
Reduction of serum triglyceride levels by polyunsaturated fat Studies on the mode of action and on very low density lipoprotein composition
Chait, A., Onitiri, A. C., Nicoll, A., Rabaya, E., Davies, J. S., & Lewis, B. (1974) · Atherosclerosis · doi:10.1016/0021-9150(74)90017-3 · Cited by 115 · see citing works
Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.
Kane, J. P., Chen, G. C., Hamilton, R. L., Hardman, D. A., Malloy, M. J., & Havel, R. J. (1983) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.3.1.47 · Cited by 106 · see citing works
Simultaneous determination of retinol and retinyl esters in serum or plasma by reversed-phase high-performance liquid chromatography.
DeRuyter, M. G., & Leenheer, A. P. D. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.11.1920 · Cited by 106 · see citing works
The effects of salmon oil upon plasma lipids, lipoproteins, and triglyceride clearance.
Harris, W. S., & CONNOR, W. E. (1980) · PubMed · Cited by 96 · see citing works
Increased sterol excretion with polyunsaturated-fat high-cholesterol diets
Nestel, P. J., Havenstein, N., Homma, Y., Scott, T., & Cook, L. J. (1975) · Metabolism · doi:10.1016/0026-0495(75)90020-7 · Cited by 94 · see citing works
Isolation and characterization of the apolipoprotein E receptor from canine and human liver.
Hui, D. Y., Brecht, W. J., Hall, E. A., Friedman, G., Innerarity, T. L., & Mahley, R. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35655-7 · Cited by 92 · see citing works
High affinity binding of chylomicron remnants to rat liver plasma membranes.
Carrella, M., & Cooper, A. D. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.338 · Cited by 91 · see citing works
Contraceptive steroids increase hepatic uptake of chylomicron remnants in healthy young women.
Berr, F., Eckel, R. H., & Kern, F. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38811-8 · Cited by 70 · see citing works
Plasma lipoprotein retinoids after vitamin A feeding in normal man: Minimal appearance of retinyl esters among low-density lipoproteins
Wilson, D. E., Chan, I.-F., & Ball, M. (1983) · Metabolism · doi:10.1016/0026-0495(83)90016-1 · Cited by 67 · see citing works
Alimentary lipemia: plasma high-density lipoproteins and apolipoproteins CII and CIII in healthy subjects
Kashyap, M. L., Barnhart, R. L., Srivastava, L., Perisutti, G., Allen, C., Hogg, E., Glueck, C. J., & Jackson, R. L. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.2.233 · Cited by 56 · see citing works
Effect of dietary fat composition on the metabolism of triacylglycerol-rich plasma lipoproteins in the postprandial phase in meal-fed rats.
Groot, P. H. E., de Boer, B. C., Haddeman, E., Houtsmuller, U. M. T., & Hülsmann, W. C. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38505-9 · Cited by 52 · see citing works
Postchallenge plasma lipoprotein retinoids: Chylomicron remnants in endogenous hypertriglyceridemia
Wilson, D. E., Chan, I.-F., Buchi, K. N., & Horton, S. C. (1985) · Metabolism · doi:10.1016/0026-0495(85)90193-3 · Cited by 51 · see citing works
Plasma decay of chylomicron remnants is not affected by heparin-stimulated plasma lipolytic activity in normal fasting man.
Berr, F., Eckel, R. H., & Kern, F. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34315-7 · Cited by 51 · see citing works
Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits.
Stender, S., & Zilversmit, D. B. (1982) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.2.6.493 · Cited by 47 · see citing works
Arterial influx of esterified cholesterol from two plasma lipoprotein fractions and its hydrolysis in vtvo in hype rcholesterolemic rabbits
Steender, S., & Zilversmit, D. B. (1981) · Atherosclerosis · doi:10.1016/0021-9150(81)90092-7 · Cited by 46 · see citing works
Activity of heparin-releasable liver lipase
Hülsmann, W. C., Oerlemans, M. C., & Jansen, H. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90043-0 · Cited by 40 · see citing works
Polyunsaturated Ruminant Fats and Cholesterol Metabolism in Man
Nestel, P. J., Havenstein, N., Scott, T. W., & Cook, L. J. (1974) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1974.tb03224.x · Cited by 37 · see citing works
Present Status of Polyunsaturated Fats in the Prevention of Cardiovascular Disease
Illingworth, D., & Connor, W. (1980) · Springer eBooks · doi:10.1007/978-1-4757-1349-7_46 · Cited by 11 · see citing works
Effects of Dietary-Fat Saturation on the Composition of Very-Low-Density Lipoproteins and on the Metabolism of their Major Apoprotein, Apolipoprotein B
Shepherd, J., Packard, C. J., TAUNTON, D., & GROTTO, A. M. (1978) · Biochemical Society Transactions · doi:10.1042/bst0060779 · Cited by 11 · see citing works

Flagged first, then by citations

Research works printed but not linked: 5

Harris, W. S., and W. E. Connor. 1980. The effect ofsalmon oil upon plasma lipid, lipoprotein and triglyceride clearance. Trans. Assoc. Am. Phys. 43:148-155.
Schoefe, G. I., and J. E. French. 1968. Vascular permeability to paticulate fate: morphological observation on levels of lactating mam- mary gland and of lung. Proc. R. Soc. Lond. B Biol. 169:153-165.
Washington, D. C. 45. Harris, J. A., and F. G. Benedict. 1919. Biometric study ofbasal metabolism in man. Carnegie Institute Washington Pub. No. 279. J. B. Lippincott Co., Philadelphia, PA.
Lindgren, F. T., L. C. Jensen, and F. T. Hatch. 1972. The isolation and quantitative analysis of serum lipoproteins in blood lipids and lipoproteins. In Quantitation, Composition, and Metabo- lism. G. S. Nelson, editor. Wiley Interscience, New York. 181-274.
W. H. Kunan, and R. T. Holman, editors. Chapter 8. American Oil Chemists Society, Champaign, IL. 139-161.

Sorted by citations

The Metabolic Syndrome
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works
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Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,225 · see citing works
Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms
Kinsella, J. E., Lokesh, B. R., & Stone, R. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.1.1 · Cited by 717 · see citing works
Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women
Hu, F. B., Stampfer, M. J., Manson, J. E., Ascherio, A., Colditz, G. A., Speizer, F. E., Hennekens, C. H., & Willett, W. C. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1001 · Cited by 661 · see citing works
Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease.
Sacks, F., & Katan, M. (2002) · American Journal of Medicine · doi:10.1016/s0002-9343(01)00987-1 · Cited by 523 · see citing works
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Breslow, J. L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1477s · Cited by 404 · see citing works
Self-citation
Dietary fat and serum lipids: an evaluation of the experimental data
Hegsted, D., Ausman, L., Johnson, J., & Dallal, G. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.6.875 · Cited by 515 · see citing works
M <scp>USCLE</scp> T <scp>RIGLYCERIDE AND</scp> I <scp>NSULIN</scp> R <scp>ESISTANCE</scp>
Kelley, D. E., Goodpaster, B. H., & Storlien, L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102912 · Cited by 364 · see citing works
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348 · see citing works
Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism
López‐Miranda, J., Williams, C. M., & Lairon, D. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450774268x · Cited by 321 · see citing works
Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet
Shimomura, Y., Tamura, T., & Suzuki, M. (1990) · The Journal of Nutrition · doi:10.1093/jn/120.11.1291 · Cited by 287 · see citing works
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
Yki-Järvinen, H., Luukkonen, P. K., Hodson, L., & Moore, J. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00472-y · Cited by 294 · see citing works
n−3 Fatty acids and the metabolic syndrome
Carpentier, Y., Portois, L., & Malaisse, W. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1499s · Cited by 283 · see citing works
Fish oil and cardiovascular disease: lipids and arterial function
Nestel, P. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.228s · Cited by 265 · see citing works
Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications
Bays, H., Tighe, A., Sadovsky, R., & Davidson, M. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.391 · Cited by 271 · see citing works
Manipulation of then-3 polyunsaturated fatty acid composition of avian eggs and meat
Leskanich, C. O., & Noble, R. C. (1997) · World s Poultry Science Journal · doi:10.1079/wps19970015 · Cited by 263 · see citing works
Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich remnant lipoproteins
Zilversmit, D. B. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.1.153 · Cited by 262 · see citing works
Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans.
Schneeman, B. O., Kotite, L., Todd, K., & Havel, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2069 · Cited by 255 · see citing works
Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?
Das, U. N. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0226 · Cited by 238 · see citing works
Postprandial lipemia, fenofibrate and coronary artery disease
Simpson, H., Williamson, C., Olivecrona, T., Pringle, S., MacLean, J. A., Lorimer, A. R., Bonnefous, F., Bogaievsky, Y., Packard, C. J., & Shepherd, J. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90111-u · Cited by 229 · see citing works
Effects Of N-3 Fatty Acids On Lipid Metabolism
Nestel, P. J. (1990) · Annual Review of Nutrition · doi:10.1146/annurev.nu.10.070190.001053 · Cited by 223 · see citing works
Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years
Weintraub, M. S., Grosskopf, I., Rassin, T., Miller, H. I., Charach, G., Rotmensch, H. H., Liron, M., Rubinstein, A., & Iaina, A. (1996) · BMJ · doi:10.1136/bmj.312.7036.935 · Cited by 216 · see citing works
Self-citation
ApoE Polymorphism and Fish Oil Supplementation in Subjects With an Atherogenic Lipoprotein Phenotype
Minihane, A. M., Khan, S., Leigh-Firbank, E. C., Talmud, P., Wright, J. W., Murphy, M. C., Griffin, B. A., & Williams, C. M. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.8.1990 · Cited by 215 · see citing works
Effects of fish oil on VLDL triglyceride kinetics in humans
Harris, W., We, C., Illingworth, D. R., Rothrock, D. W., & Foster, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42339-9 · Cited by 211 · see citing works
Are deficits of arachidonic and docosahexaenoic acids responsible for the neural and vascular complications of preterm babies?
Crawford, M. A., Costeloe, K., Ghebremeskel, K., Phylactos, A., Skirvin, L., & Stacey, F. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.1032s · Cited by 198 · see citing works
New insights into the regulation of chylomicron production
Dash, S., Xiao, C., Morgantini, C., & Lewis, G. F. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034338 · Cited by 194 · see citing works
Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism.
Roche, H. M., & Gibney, M. J. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.232s · Cited by 195 · see citing works
Dietaryn-3 andn-6 fatty acids alter avian metabolism: metabolism and abdominal fat deposition
Newman, R. E., Bryden, W. L., Fleck, E., Ashes, J. R., Buttemer, W. A., Storlien, L. H., & Downing, J. A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002580 · Cited by 182 · see citing works
Correlation of serum triglyceride and its reduction by ω-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
Pownall, H. J., Brauchi, D., Kilinç, C., Osmundsen, K., Pao, Q., Payton-Ross, C., Gotto, A. M., & Ballantyne, C. M. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00301-3 · Cited by 179 · see citing works
Postprandial triglyceridemia and carotid atherosclerosis in middle-aged subjects
Ryu, J. E., Howard, G., Craven, T. E., Bond, M. G., Hagaman, A. P., & Crouse, J. R. (1992) · Stroke · doi:10.1161/01.str.23.6.823 · Cited by 169 · see citing works
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men1–3
Timlin, M. T., & Parks, E. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.35 · Cited by 170 · see citing works
Are fish oils beneficial in the prevention and treatment of coronary artery disease?
Connor, S., & CONNOR, W. E. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.1020s · Cited by 167 · see citing works
Long-chain omega 3 fatty acids, blood lipids and cardiovascular risk reduction
Mori, T. A., & Beilin, L. J. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200102000-00003 · Cited by 164 · see citing works
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review
Oscarsson, J., & Hurt-Camejo, E. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0541-3 · Cited by 158 · see citing works
Methodology for studying postprandial lipid metabolism
Lairon, D., López‐Miranda, J., & Williams, C. M. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602749 · Cited by 159 · see citing works
Polyunsaturated Fatty Acids and Cardiovascular Health
Kris‐Etherton, P. M., Hecker, K. D., & Binkoski, A. E. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00013.x · Cited by 159 · see citing works
Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins
Cohn, J. S., Marcoux, C., & Davignon, J. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.10.2474 · Cited by 156 · see citing works
Postprandial Lipoprotein Metabolism in Normal and Obese Subjects: Comparison after the Vitamin A Fat-Loading Test*
Lewis, G. F., O’Meara, N., Soltys, P. A., Blackman, J. D., Iverius, P., Druetzler, A. F., Getz, G. S., & Polonsky, K. S. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-4-1041 · Cited by 152 · see citing works
Perilla Oil Prevents the Excessive Growth of Visceral Adipose Tissue in Rats by Down-Regulating Adipocyte Differentiation ,
Okuno, M., Kajiwara, K., Imai, S., Kobayashi, T., Honma, N., Maki, T., Suruga, K., Goda, T., Takase, S., Muto, Y., et al. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1752 · Cited by 154 · see citing works
Butter Differs from Olive Oil and Sunflower Oil in Its Effects on Postprandial Lipemia and Triacylglycerol-Rich Lipoproteins after Single Mixed Meals in Healthy Young Men
Mekki, N., Charbonnier, M., Borel, P., Léonardi, J., Juhel, C., Portugal, H., & Lairon, D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3642 · Cited by 153 · see citing works
Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans
Rambjør, G. S., W»len, A. I., Windsor, S. L., & Harris, W. S. (1996) · Lipids · doi:10.1007/bf02637050 · Cited by 147 · see citing works
Role of n−3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease
Jacobson, T. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1981s · Cited by 147 · see citing works
Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype
Khan, S., Minihane, A.-M., Talmud, P. J., Wright, J. W., Murphy, M. C., Williams, C. M., & Griffin, B. A. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30473-9 · Cited by 145 · see citing works
Postprandial Hyperlipidemia and Remnant Lipoproteins
Masuda, D., & Yamashita, S. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv16003 · Cited by 145 · see citing works
Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100
Karpe, F., Bell, M., Björkegren, J., & Hamsten, A. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.2.199 · Cited by 143 · see citing works
Fish Oil for the Treatment of Cardiovascular Disease
Weitz, D., Weintraub, H., Fisher, E., & Schwartzbard, A. Z. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181ea0de0 · Cited by 138 · see citing works
Effects of dietary fats on blood lipids: a review of direct comparison trials
DiNicolantonio, J. J., & O’Keefe, J. H. (2018) · Open Heart · doi:10.1136/openhrt-2018-000871 · Cited by 136 · see citing works
Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
Harris, W., Lu, G., Rambjør, G., Wõlen, A., Ontko, J., Cheng, Q., & Windsor, S. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.254 · Cited by 135 · see citing works
Omega-3 Fatty Acids
Schmidt, E. B., & Dyerberg, J. (1994) · Drugs · doi:10.2165/00003495-199447030-00003 · Cited by 136 · see citing works
N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes.
Wang, H., Chen, X., & Fisher, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116340 · Cited by 133 · see citing works
Lipid Requirements of Infants: Implications for Nutrient Composition of Fortified Complementary Foods
Uauy, R. D., & Castillo, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2962s · Cited by 126 · see citing works
Impaired chylomicron remnant clearance in familial combined hyperlipidemia.
Cabezas, M. C., de Bruin, T. W. A., Jansen, H., Kock, L. A., Kortlandt, W., & Erkelens, D. W. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.6.804 · Cited by 123 · see citing works
Influence ofn-6versusn-3Polyunsaturated Fatty Acids in Diets Low in Saturated Fatty Acids on Plasma Lipoproteins and Hemostatic Factors
Sanders, T. A. B., Oakley, F. R., Miller, G. J., Mitropoulos, K. A., Crook, D., & Oliver, M. F. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3449 · Cited by 122 · see citing works
Metabolic basis of HIV-lipodystrophy syndrome
Sekhar, R. V., Jahoor, F., White, A. C., Pownall, H. J., Visnegarwala, F., Rodriguez‐Barradas, M. C., Sharma, M. D., Reeds, P. J., & Balasubramanyam, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00058.2002 · Cited by 122 · see citing works
Algal Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese Adults
Neff, L. M., Culiner, J., Cunningham-Rundles, S., Seidman, C., Meehan, D., Maturi, J., Wittkowski, K. M., Levine, B., & Breslow, J. L. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.130021 · Cited by 121 · see citing works
Self-citation
Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men
Tholstrup, T., Sandström, B., Bysted, A., & Hølmer, G. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.198 · Cited by 120 · see citing works
Dietary Fatty Acids, Lipoproteins, and Cardiovascular Disease
McNamara, D. J. (1992) · Advances in food and nutrition research · doi:10.1016/s1043-4526(08)60107-2 · Cited by 120 · see citing works
Dietary intake of stearidonic acid–enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety
Lemke, S. L., Vicini, J. L., Su, H. L., Goldstein, D. A., Nemeth, M. A., Krul, E. S., & Harris, W. S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29072 · Cited by 118 · see citing works
The influence of positional distribution of fatty acids in native, interesterified and structure-specific lipids on lipoprotein metabolism and atherogenesis
Kubow, S. J. (1996) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(96)00106-4 · Cited by 118 · see citing works
Eicosapentanoic Acid Reduces Plasma Levels of Remnant Lipoproteins and Prevents in Vivo Peroxidation of LDL in Dialysis Patients
Ando, M., Sanaka, T., & Nihei, H. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10102177 · Cited by 113 · see citing works
Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats
Ikeda, I., Sasaki, E., Yasunami, H., Nomiyama, S., Nakayama, M., Sugano, M., Imaizumi, K., & Yazawa, K. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00180-8 · Cited by 110 · see citing works
The Impact of Postprandial Lipemia in Accelerating Atherothrombosis
Roche, H. M., & Gibney, M. J. (2000) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/204748730000700504 · Cited by 110 · see citing works
Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes
West, S. G., Hecker, K. D., Mustad, V. A., Nicholson, S., Schoemer, S. L., Wagner, P., Hinderliter, A. L., Ulbrecht, J., Ruey, P., & Kris-Etherton, P. M. (2005) · Diabetologia · doi:10.1007/s00125-004-1600-7 · Cited by 105 · see citing works
Fish oil reduces postprandial triglyceride concentrations without accelerating lipid emulsion removal rates
Harris, W., & Muzio, F. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.1.68 · Cited by 105 · see citing works
Metabolic fate of saturated and monounsaturated dietary fats: The Mediterranean diet revisited from epidemiological evidence to cellular mechanisms
Bergouignan, A., Momken, I., Schoeller, D. A., Simon, C., & Blanc, S. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.004 · Cited by 97 · see citing works
Diet and coronary heart disease: beyond dietary fats and low-density-lipoprotein cholesterol
Fraser, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.1117s · Cited by 97 · see citing works
Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration.
Mitropoulos, K. A., Miller, G. J., Martin, J., Reeves, B. E., & Cooper, J. A. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.2.214 · Cited by 97 · see citing works
Olive oil, corn oil, and n−3 fatty acids differently affect lipids, lipoproteins, platelets, and superoxide formation in type II hypercholesterolemia
Sirtori, C., Gatti, E., Tremoli, E., Galli, C. L., Gianfranceschi, G., Franceschini, G., Colli, S., MADERNA, P., Marangoni, F., & Perego, P. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.1.113 · Cited by 95 · see citing works
Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia
Hansen, J., Grimsgaard, S., Nilsen, H., Nordøy, A., & Bønaa, K. H. (1998) · Lipids · doi:10.1007/s11745-998-0188-8 · Cited by 91 · see citing works
Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed,,,
Jackson, K. G., Robertson, M. D., Fielding, B. A., Frayn, K. N., & Williams, C. M. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.942 · Cited by 92 · see citing works
Dietary supplementation of very long-chain n-3 fatty acids decreases whole body lipid utilization in the rat
Rustan, A. C., Hustvedt, B. E., & Drevon, C. A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36960-1 · Cited by 89 · see citing works
Does Dietary Fat Influence Insulin Action?a
Storlien, L. H., Kriketos, A. D., Jenkins, A. B., Baur, L. A., Pan, D. A., Tapsell, L. C., & Calvert, G. D. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51842.x · Cited by 88 · see citing works
Influence of a stearic acid–rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects
Sanders, T. A. B., Oakley, F. R., Cooper, J. A., & Miller, G. J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.4.715 · Cited by 87 · see citing works
Postprandial lipid metabolism: effects of dietary fatty acids
Williams, C. M. (1997) · Proceedings of The Nutrition Society · doi:10.1079/pns19970068 · Cited by 87 · see citing works
Good Fats versus Bad Fats: A Comparison of Fatty Acids in the Promotion of Insulin Resistance, Inflammation, and Obesity.
DiNicolantonio, J. J., & O’Keefe, J. H. (2017) · Europe PMC (PubMed Central) · Cited by 85 · see citing works
Inflammation, obesity, and fatty acid metabolism: influence ofn-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome
Robinson, L. E., Buchholz, A. C., & Mazurak, V. C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-087 · Cited by 86 · see citing works
Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia
Micallef, M. A., & Garg, M. L. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.009 · Cited by 84 · see citing works
Fasting Lipoprotein and Postprandial Triacylglycerol Responses to a Low-Carbohydrate Diet Supplemented with n-3 Fatty Acids
Volek, J. S., Gómez, A. L., & Kraemer, W. J. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718935 · Cited by 84 · see citing works
The effects of saturated fat and n-6 polyunsaturated fat on postprandial lipemia and hemostatic activity
Saloma, V., Rasi, V., Pekkanen, J., Jauhiainen, M., Vahtera, E. M., Pietinen, P., KORHONEN, H. J., Kuulasmaa, K., & Ehnholm, C. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90034-r · Cited by 84 · see citing works
(n-3) Fatty Acid Supplementation in Moderately Hypertriglyceridemic Adults Changes Postprandial Lipid and Apolipoprotein B Responses to a Standardized Test Meal
Tinker, L. F., Parks, E. J., Behr, S. R., Schneeman, B. O., & Davis, P. A. (1999) · Journal of Nutrition · doi:10.1093/jn/129.6.1126 · Cited by 83 · see citing works
Effects of <i>n</i> -3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects
Williams, C. M., Moore, F., Morgan, L., & Wright, J. (1992) · British Journal of Nutrition · doi:10.1079/bjn19920123 · Cited by 81 · see citing works
Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil
de Bruin, T. W. A., Brouwer, C., Trip, M. V. L.-S., Jansen, H., & Erkelens, D. W. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.477 · Cited by 81 · see citing works
Postprandial chylomicrons and VLDLs in severe hypertriacylglycerolemia are lowered more effectively than are chylomicron remnants after treatment with n−3 fatty acids
Westphal, S., Orth, M., Ambrosch, A., Osmundsen, K., & Luley, C. H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.914 · Cited by 79 · see citing works
Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness
Dias, C. B., Moughan, P. J., Wood, L. G., Singh, H., & Garg, M. L. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0568-5 · Cited by 79 · see citing works
Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII)
Sanders, T. A. B., de Grassi, T., Miller, G. J., & Morrissey, J. H. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00335-4 · Cited by 78 · see citing works
Therapeutic Response to Medium-Chain Triglycerides and ω-3 Fatty Acids in a Patient With the Familial Chylomicronemia Syndrome
Rouis, M., Dugi, K. A., Previato, L., Patterson, A. P., Brunzell, J. D., Brewer, H. B., & Santamarina-Fojo, S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1400 · Cited by 78 · see citing works
Severe defect in clearing postprandial chylomicron remnants in dialysis patients
Weintraub, M. S., Burstein, A., Rassin, T., Liron, M., Ringel, Y., Cabili, S., Blum, M., Peer, G., & Iaina, A. (1992) · Kidney International · doi:10.1038/ki.1992.411 · Cited by 78 · see citing works
Self-citation
Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels.
Cobb, M. M., Teitlebaum, H., RISCH, N. J., Jekel, J., & Ostfeld, A. M. (1992) · Circulation · doi:10.1161/01.cir.86.3.849 · Cited by 78 · see citing works
Individual Responses to a Cholesterol-Lowering Diet in 50 Men With Moderate Hypercholesterolemia
Denke, M. A. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420030127013 · Cited by 77 · see citing works
Physical activity and postprandial lipidemia: Are energy expenditure and lipoprotein lipase activity the real modulators of the positive effect?
Peddie, M. C., Rehrer, N. J., & Perry, T. L. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.002 · Cited by 75 · see citing works
Peroxisome proliferator-activated receptors and the metabolic syndrome
Bragt, M. C. E., & Popeijus, H. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.053 · Cited by 74 · see citing works
Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4‐dienoyl‐CoA reductase gene expression in rats
Willumsen, N., Vaagenes, H., Lie, Ø. H., Rustan, A. C., & Berge, R. K. (1996) · Lipids · doi:10.1007/bf02523828 · Cited by 74 · see citing works
Differences in postprandial lipaemic response between Northern and Southern Europeans
Zampelas, A., Roche, H. M., Knapper, J. M. E., Jackson, K. G., Tornaritis, M. J., Hatzis, C., Gibney, M. J., Kafatos, A., GOULD, B. J., Wright, J., et al. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00061-6 · Cited by 74 · see citing works
Intestinal absorption of β-carotene ingested with a meal rich in sunflower oil or beef tallow: postprandial appearance in triacylglycerol-rich lipoproteins in women
Hu, X., Jandacek, R. J., & White, W. S. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1170 · Cited by 73 · see citing works
Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states
Gill, J. M. R., Herd, S. L., Vora, V., & Hardman, A. E. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0788-9 · Cited by 70 · see citing works
Increased n−6 polyunsaturated fatty acids do not attenuate the effects of long-chain n−3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians
Brady, L. M., Lovegrove, S. S., Lesauvage, S. V., Gower, B. A., Minihane, A. M., Williams, C. M., & Lovegrove, J. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.983 · Cited by 70 · see citing works
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Bergeron, N., & Havel, R. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2111 · Cited by 70 · see citing works
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Marckmann, P., Bladbjerg, E., & Jespersen, J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3384 · Cited by 70 · see citing works
A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n − 6 and n − 3 polyunsaturated fatty acids
SINGER, P. A., Wirth, M., & Berger, I. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90162-c · Cited by 69 · see citing works
Postprandial serum glucose, insulin, and lipoprotein responses to high- and low-fiber diets
Anderson, J. W., O'Neal, D. S., Riddell-Mason, S., Floore, T. L., Dillon, D. W., & Oeltgen, P. R. (1995) · Metabolism · doi:10.1016/0026-0495(95)90236-8 · Cited by 68 · see citing works

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Bergeron, N., & Havel, R. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2111 · Cited by 70 · see citing works
We-P12:305 Porphyromonas gingivalis induces platelet aggregation and blood coagulation — role of gingipains and lipopolysaccharides
Bengtsson, T., Nylander, M., Skoglund, C., Tynngrd, N., Kälvegren, H., Wallin, L., Grenegrd, M., & Lindahl, T. L. (2006) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(06)81658-2
Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans
Chung, B.-H., Cho, B. S., Liang, P., Doran, S., Osterlund, L., Oster, R. A., Darnell, B. E., & Franklin, F. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1145 · Cited by 28 · see citing works
Postprandial Lipid Responses do not Differ Following Consumption of Butter or Vegetable Oil when Consumed with Omega‐3 Polyunsaturated Fatty Acids
Dias, C. B., Phang, M., Wood, L. G., & Garg, M. L. (2015) · Lipids · doi:10.1007/s11745-015-4003-2 · Cited by 8 · see citing works
Th-W56:2 Clinical studies on biomarkers
Ballantyne, C. M. (2006) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(06)81915-x

Authors: Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L.
Affiliations: Rockefeller University (US)
Hadassah Medical Center (IL)
ORCID: Zechner, R
Brown, A
Breslow, J L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1988-12-01
Volume: 82
Issue: 6
Pages: 1884-1893
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113806
PMC: PMC442768
OpenAlex: W1974647064
Cited by: 331
References: 72
Citations by year: 2026: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 6
FWCI: 8.92
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pew Charitable Trusts
American Heart Association
National Institutes of Health
National Institute on Aging (AG 04727)
National Heart, Lung, and Blood Institute (HL 33714, HL32435)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: dietary polyunsaturated fatty acids, omega-6 fatty acids, omega-3 fatty acids, saturated fat, postprandial lipoprotein metabolism, chylomicrons, retinyl palmitate, triglyceride-rich lipoproteins, lipolysis
MeSH terms: Retinyl Esters, Adult, Chylomicrons, Dietary Fats, Diterpenes, Fatty Acids, Unsaturated, Glycated Hemoglobin, Humans, Insulin, Lipase, Lipolysis, Lipoproteins, Male, Platelet Count, Reference Values, Vitamin A

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Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.

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