Cited by 335Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits In Vivo: Molecular Size as a Determinant of Fractional Loss From the Intima–Inner Media

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Nordestgaard, Børge G., Wootton, Richard, Lewis, Barry·1995·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.15.4.534

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Abstract

Abstract To explore possible mechanisms whereby the triglyceride-rich lipoproteins IDL and VLDL may promote atherosclerosis, fractional loss of these lipoproteins from the intima–inner media was measured in vivo in genetically hyperlipidemic rabbits of the St Thomas’s Hospital strain and compared with the fractional loss of LDL, HDL, and albumin. These rabbits exhibit elevated plasma levels of VLDL, IDL, and LDL. In each rabbit, two aliquots of the same macromolecule, one iodinated with 125 I and the other with 131 I, respectively, were injected intravenously on average 24 and 3 hours, respectively, before removal of the aortic intima–inner media. The fractional loss from the intima–inner media of newly entered macromolecules was then calculated. The average fractional losses for VLDL, IDL, LDL, HDL, and albumin in lesioned aortic arches were 0.1%/h (n=4), −0.2%/h (n=3), 1.8%/h (n=4), 11.4%/h (n=3), and 26.3%/h (n=1), respectively; in nonlesioned aortic arches fractional losses for IDL, LDL, HDL, and albumin were 1.7%/h (n=1), 0.6%/h (n=2), 14.6%/h (n=3), and 25.9%/h (n=3). In both lesioned and nonlesioned aortic arches, the logarithms of these fractional loss values were inversely and linearly dependent on the diameter of the macromolecules (R2=.57,P=.001 and R2=.84,P<.001), as determined from electron photomicrographs of negatively stained lipoproteins. These results suggest that after uptake into the arterial intima, VLDL and IDL as well as LDL are selectively retained in comparison with HDL and albumin.

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Authors: Nordestgaard, B. G., Wootton, R., & Lewis, B.
Affiliations: University of Copenhagen (DK)
ORCID: Nordestgaard, Børge G.
Wootton, Richard
Lewis, Barry
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1995-04
Volume: 15
Issue: 4
Pages: 534-542
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.15.4.534
OpenAlex: W2150460597
Cited by: 334
References: 49
Citations by year: 2026: 11 · 2025: 17 · 2024: 15 · 2023: 21 · 2022: 18 · 2021: 22 · 2020: 23 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 8 · 2015: 13 · 2014: 10 · 2013: 6 · 2012: 3
FWCI: 3.44
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Hjerteforeningen
Sundhed og Sygdom, Det Frie Forskningsråd
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: VLDL, IDL, low-density lipoprotein, HDL cholesterol, arterial intima, atherosclerosis, lipoprotein retention, aortic arch, lipoprotein particle size, serum lipoproteins
MeSH terms: Albumins, Animals, Arteries, Female, Hyperlipidemias, Lipoproteins, Lipoproteins, LDL, Lipoproteins, VLDL, Male, Microscopy, Electron, Particle Size, Rabbits, Tunica Intima, Tunica Media, Lipoproteins, IDL

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Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits In Vivo: Molecular Size as a Determinant of Fractional Loss From the Intima–Inner Media

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