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Cited by 7Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryPlatelet Disorders and Treatments

Replacement therapy with levothyroxine modulates platelet activation in recent-onset post-thyroidectomy subclinical hypothyroidism

Desideri, G., Bocale, R., D'Amore, A., Necozione, S., Boscherini, M., Carnassale, G., Barini, A., Barini, A. +2 more·2017·Nutrition, Metabolism and Cardiovascular Diseases
DOI 10.1016/j.numecd.2017.07.002
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Abstract

Background and aim Subclinical hypothyroidism has been linked to increased risk of atherosclerotic disease. Soluble CD40 ligand (sCD40L), mainly derived from activated platelets, and the lipid peroxidation product 8-iso-prostaglandin F 2α (8-iso-PGF 2α) are known to play a relevant pathophysiological role in atherogenesis. In this study, we analyzed the relationship between thyroid hormones and circulating levels of sCD40L and 8-iso-PGF 2α in patient with recent-onset post-thyroidectomy subclinical hypothyroidism under replacement therapy.Methods and results Circulating levels of thyroid hormones, sCD40L, and 8-iso-PGF 2α were assessed in 40 recently thyroidectomized patients (33 females, mean age 52.0 ± 11.7 years) at baseline (5-7 day after surgery) and after 2 months under replacement therapy with levothyroxine (LT-4). At baseline, circulating levels of thyroid hormones were indicative of a subclinical hypothyroidism (TSH 7.7 ± 3.9 μU/mL, FT3 1.8 ± 0.6 pg/mL, and FT3 8.9 ± 3.0 pg/mL). Circulating levels of sCD40L and 8-iso-PGF 2α were directly correlated with each other (r = 0.360, p = 0.023) and with TSH levels (r = 0.322, p = 0.043 and r = 0.329 p = 0.038, respectively). After 2 months under the replacement therapy with LT-4 circulating levels of TSH (from 7.7 ± 3.9 to 2.7 ± 2.8 μU/mL, p < 0.0001), sCD40L (from 6.11 ± 2.41 to 2.43 ± 2.00 ng/mL, p < 0.0001) and 8-iso-PGF 2α (from 45.33 ± 6.94 to 40.36 ± 6.20, p < 0.0001) significantly decreased. Changes in circulating levels of sCD40L and 8-iso-PGF 2α were directly correlated with each other (r = 0.349 p = 0.028) and with changes in TSH levels (r = 0.367 p = 0.020 and r = 0.339 p = 0.032, respectively).Conclusion Our study suggests an influential role of TSH on proatherogenic activation of platelets, probably through enhanced lipid peroxidation. These findings could partially explain the increased susceptibility of patients with subclinical hypothyroidism to develop atherosclerotic disease.

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  • Correction of TSH levels to normal using LT4 replacement corrects these abnormalities.

    “Correction of TSH levels to normal using LT4 replacement correct these abnormalities”

    From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [111]

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Authors
Desideri, G., Bocale, R., D'Amore, A., Necozione, S., Boscherini, M., Carnassale, G., Barini, A., Barini, A., Bellantone, R., & Lombardi, C. P.
Affiliations
  • University of L'Aquila (IT)
  • Università Cattolica del Sacro Cuore (IT)
Corresponding author
Desideri, G.
ORCID
Venue
Nutrition, Metabolism and Cardiovascular Diseases
Publisher
Elsevier BV
Published
2017-10
Volume
27
Issue
10
Pages
896-901
ISSN
0939-4753 (ISSN-L)
DOI
10.1016/j.numecd.2017.07.002
OpenAlex
W2734928011
Cited by
7
References
31
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1
FWCI
0.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords
subclinical hypothyroidism, post-thyroidectomy, levothyroxine replacement therapy, platelet activation, soluble CD40 ligand, 8-isoprostane, lipid peroxidation, atherogenesis, thyroid-stimulating hormone, thyroid hormones, atherosclerosis risk, thyroidectomy complications
MeSH terms
Adult, Blood Platelets, Female, Humans, Hypothyroidism, Male, Middle Aged, Thyroidectomy, Thyrotropin, Thyroxine, Time Factors, Lipid Peroxidation, Dinoprost, Biomarkers, Platelet Activation, Treatment Outcome, Hormone Replacement Therapy, CD40 Ligand, Asymptomatic Diseases

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