The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary Arteries
Abstract
Abstract—There is increasing evidence that complement activation may play a role in atherogenesis. Complement proteins have been demonstrated to be present in early atherosclerotic lesions of animals and humans, and cholesterol-induced atherosclerotic lesion formation is reduced in complement-deficient animals. Potential complement activators in atherosclerotic lesions are now a subject matter of debate. C-reactive protein (CRP) is an acute-phase protein that is involved in inflammatory processes in numerous ways. It binds to lipoproteins and activates the complement system via the classic pathway. In this study we have investigated early atherosclerotic lesions of human coronary arteries by means of immunohistochemical staining. We demonstrate here that CRP deposits in the arterial wall in early atherosclerotic lesions with 2 predominant manifestations. First, there is a diffuse rather than a focal deposition in the deep fibroelastic layer and in the fibromuscular layer of the intima adjacent to the media. In this location, CRP frequently colocalizes with the terminal complement complex. Second, the majority of foam cells below the endothelium show positive staining for CRP. In this location, no colocalization with the terminal complement proteins can be observed. Our data suggest that CRP may promote atherosclerotic lesion formation by activating the complement system and being involved in foam cell formation.
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Cites
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The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
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Elevation of C-reactive protein in “active” coronary artery disease
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COMPLEMENT ACTIVATION BY C‐REACTIVE PROTEIN COMPLEXES*
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Expression of C-reactive protein by alveolar macrophages
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Cited by
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk
Ridker, P. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.052 · Cited by 623
Chambers, J. C., Eda, S., Bassett, P., Karim, Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., & Kooner, J. S. (2001) · Circulation · doi:10.1161/01.cir.104.2.145 · Cited by 438
Production of the Long Pentraxin PTX3 in Advanced Atherosclerotic Plaques
Rolph, M. S., Zimmer, S., Bottazzi, B., Garlanda, C., Mantovani, A., & Hansson, G. K. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000015595.95497.2f · Cited by 284
Metadata
- Authors
- Torzewski, J., Torzewski, M., Bowyer, D. E., Fröhlich, M., Koenig, W., Waltenberger, J., Fitzsimmons, C., & Hombach, V.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1998-09
- Volume
- 18
- Issue
- 9
- Pages
- 1386-1392
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2117770728
- Cited by
- 561
- References
- 26
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary Arteries. https://app.cochat.ai/papers/10.1161/01.atv.18.9.1386
- The paper
- Torzewski, J., Torzewski, M., Bowyer, D. E., Fröhlich, M., Koenig, W., Waltenberger, J., Fitzsimmons, C., & Hombach, V. (1998). C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary Arteries. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.18.9.1386
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
