C-reactive protein: a critical update
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Via APPs, hepatocytes directly contribute to extracellular pathogen clearance via complement-mediated antigen opsonization.
“Via APPs, hepatocytes directly contribute to extracellular pathogen clearance via complement-mediated antigen opsonization [34–36].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354 · see citing works
Self-citationKöenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952 · see citing works
Self-citationThompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819 · see citing works
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692 · see citing works
Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557 · see citing works
Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511 · see citing works
Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & D, E. B. M. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,479 · see citing works
Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098 · see citing works
C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages
Zwaka, T. P., Hombach, V., & Torzewski, J. (2001) · Circulation · doi:10.1161/01.cir.103.9.1194 · Cited by 845 · see citing works
C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Čermák, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 838 · see citing works
The physiological structure of human C-reactive protein and its complex with phosphocholine
Thompson, D., Pepys, M. B., & Wood, S. P. (1999) · Structure · doi:10.1016/s0969-2126(99)80023-9 · Cited by 818 · see citing works
Self-citationFreeman, D. J., Norrie, J. D., CASLAKE, M. J., Gaw, A., Ford, I., Lowe, G. D. O., O’Reilly, D. S. J., Packard, C. J., Sattar, N. A., & for the West of Scotland Coronary Prevention Study Group (2002) · Diabetes · doi:10.2337/diabetes.51.5.1596 · Cited by 720 · see citing works
Gershov, D., Kim, S., Brot, N., & Elkon, K. B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1353 · Cited by 695 · see citing works
Fröhlich, M., Imhof, A., Berg‐Beckhoff, G., Hutchinson, W. L., Pepys, M. B., Boeing, H., Muche, R., Brenner, H., & Köenig, W. (2000) · Diabetes Care · doi:10.2337/diacare.23.12.1835 · Cited by 683 · see citing works
Self-citationVigushin, D., Pepys, M., & Hawkins, P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116336 · Cited by 681 · see citing works
Self-citationCushman, M., Legault, C., Barrett-Connor, E., Stefanick, M. L., Kessler, C., Judd, H. L., Sakkinen, P. A., & Tracy, R. P. (1999) · Circulation · doi:10.1161/01.cir.100.7.717 · Cited by 660 · see citing works
Body mass index, diabetes, and C-reactive protein among U.S. adults.
Ford, E. S. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1971 · Cited by 645 · see citing works
Elevation of C-reactive protein in “active” coronary artery disease
Berk, B. C., Weintraub, W. S., & Alexander, R. W. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90079-g · Cited by 593 · see citing works
Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults
Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575 · see citing works
Torzewski, J., Torzewski, M., Bowyer, D. E., Fröhlich, M., Köenig, W., Waltenberger, J. L., Fitzsimmons, C. M., & Hombach, V. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.9.1386 · Cited by 560 · see citing works
Effect of alcohol consumption on systemic markers of inflammation
Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, M. B., & Koenig, W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04170-2 · Cited by 559 · see citing works
Self-citationSerum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
Bickerstaff, M., Botto, M., Hutchinson, W., Herbert, J., Tennent, G., Bybee, A., Mitchell, D., Cook, H., Butler, P., Walport, M., et al. (1999) · Nature Medicine · doi:10.1038/9544 · Cited by 548 · see citing works
Self-citationTargeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
Pepys, M. B., Herbert, J., Hutchinson, W. L., Tennent, G. A., Lachmann, H. J., Gallimore, J. R., Lovat, L. B., Bartfai, T., Alanine, A., Hertel, C., et al. (2002) · Nature · doi:10.1038/417254a · Cited by 540 · see citing works
Self-citationChang, M.-K., Binder, C. J., Torzewski, M., & Witztum, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192399699 · Cited by 517 · see citing works
Griselli, M., Herbert, J., Hutchinson, W. L., Taylor, K. M., Sohail, M., Krausz, T. N., & Pepys, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1733 · Cited by 507 · see citing works
Self-citationHormone Replacement Therapy and Increased Plasma Concentration of C-Reactive Protein
Ridker, P. M., Hennekens, C. H., Rifai, N., Buring, J. E., & Manson, J. E. (1999) · Circulation · doi:10.1161/01.cir.100.7.713 · Cited by 442 · see citing works
Chambers, J. C., Eda, S., Bassett, P., Karim, M. Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., & Kooner, J. S. (2001) · Circulation · doi:10.1161/01.cir.104.2.145 · Cited by 438 · see citing works
Self-citationC-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction
Lagrand, W. K., Niessen, H. W. M., Wolbink, G., Jaspars, L. H., Visser, C. A., Verheugt, F. W. A., Meijer, C. J. L. M., & Hack, C. E. (1997) · Circulation · doi:10.1161/01.cir.95.1.97 · Cited by 388 · see citing works
Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein
McLaughlin, T., Abbasi, F., Lamendola, C. A., Liang, L., Reaven, G. M., Schaaf, P., & Reaven, P. D. (2002) · Circulation · doi:10.1161/01.cir.0000041046.32962.86 · Cited by 374 · see citing works
Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction.
de Beer, F. C., Hind, C. R. K., Fox, K. M., Allan, R. M., Maseri, A., & Pepys, M. B. (1982) · Heart · doi:10.1136/hrt.47.3.239 · Cited by 357 · see citing works
Self-citationAnzai, T., Yoshikawa, T., Shiraki, H., Asakura, Y., Akaishi, M., Mitamura, H., & Ogawa, S. (1997) · Circulation · doi:10.1161/01.cir.96.3.778 · Cited by 335 · see citing works
Regulation of complement activation by C-reactive protein
Mold, C., Gewurz, H., & Du Clos, T. W. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00007-7 · Cited by 326 · see citing works
Bhakdi, S., Torzewski, M., Klouche, M., & Hemmes, M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.10.2348 · Cited by 325 · see citing works
Solid phase radioimmunoassays for human C-reactive protein
Shine, B. S. F., de Beer, F. C., & Pepys, M. B. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90005-x · Cited by 315 · see citing works
Self-citationCOMPLEMENT ACTIVATION BY C‐REACTIVE PROTEIN COMPLEXES*
Volanakis, J. E. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22140.x · Cited by 279 · see citing works
Pietlla, K. O., Harmoinen, A. P. T., Jokiniitty, J. M., & Pasternack, A. I. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015068 · Cited by 263 · see citing works
Hutchinson, W. L., Köenig, W., Fröhlich, M., Sund, M., Lowe, G. D. O., & Pepys, M. B. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.7.934 · Cited by 250 · see citing works
Self-citationRisk factors for coronary heart disease and acute-phase proteins. A population-based study
Danesh, J. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1309 · Cited by 239 · see citing works
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
Volanakis, J. E., & WIRTZ, K. W. A. (1979) · Nature · doi:10.1038/281155a0 · Cited by 238 · see citing works
Coronary C-reactive protein distribution: its relation to development of atherosclerosis
Zhang, Y. X., Cliff, W. J., Schoefl, G. I., & Higgins, G. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00105-7 · Cited by 196 · see citing works
de Beer, F. C., Soutar, A. K., Baltz, M. L., Trayner, I., Feinstein, A., & Pepys, M. B. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.1.230 · Cited by 182 · see citing works
Self-citationPhosphorylcholine: friend or foe of the immune system?
Harnett, W., & Harnett, M. M. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01419-4 · Cited by 169 · see citing works
STUDIES OF ACUTE PHASE PROTEIN
Kushner, I., & Kaplan, M. H. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.114.6.961 · Cited by 164 · see citing works
PHYLOGENETIC ASPECTS OF C‐REACTIVE PROTEIN AND RELATED PROTEINS *
Baltz, M., de Beer, F., Feinstein, A., Munn, E., Milstein, C., Fletcher, T. C., March, J., Taylor, J., Bruton, C., Clamp, J. R., et al. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22125.x · Cited by 157 · see citing works
Self-citationSzalai, A. J., McCrory, M. A., Cooper, G. S., Wu, J., & Kimberly, R. P. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363820 · Cited by 147 · see citing works
C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.
Clos, T. W. D. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.8.2553 · Cited by 124 · see citing works
Kushner, I., Rakita, L., & Kaplan, M. H. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104715 · Cited by 117 · see citing works
Comparative studies on the binding properties of human and rabbit C-reactive proteins.
Oliveira, E. B., Gotschlich, E. C., & Liu, T. Y. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.3.1396 · Cited by 98 · see citing works
C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction
Ueda, S., Ikeda, U., Yamamoto, K., Takahashi, M., Nishinaga, M., Nago, N., & Shimada, K. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90164-7 · Cited by 79 · see citing works
Human C-reactive protein does not bind to fcγRIIa on phagocyti cells
Saeland, E., van Royen‐Kerkhof, A., Hendriksen, K. A. W., Vilé-Weekhout, H., Rijkers, G. T., Sanders, E. A. M., & van de Winkel, J. G. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12418 · Cited by 45 · see citing works
Oral contraceptive use is associated with a systemic acute phase response
Fröhlich, M., Döring, A., Imhof, A., Hutchinson, W. L., Pepys, M. B., & Köenig, W. (1999) · Fibrinolysis and Proteolysis · doi:10.1054/fipr.1999.0037 · Cited by 31 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Role of C-Reactive Protein at Sites of Inflammation and Infection
Sproston, N. R., & Ashworth, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00754 · Cited by 3,053 · see citing works
Lee, D. W., Kochenderfer, J. N., Stetler-Stevenson, M., Cui, Y. K., Delbrook, C., Feldman, S. A., Fry, T. J., Orentas, R., Sabatino, M., Shah, N. N., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61403-3 · Cited by 2,898 · see citing works
Current concepts in the diagnosis and management of cytokine release syndrome.
Lee, D. W., Gardner, R., Porter, D. L., Louis, C. U., Ahmed, N., Jensen, M., Grupp, S. A., & Mackall, C. L. (2014) · Blood · doi:10.1182/blood-2014-05-552729 · Cited by 2,806 · see citing works
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
Davila, M. L., Rivière, I., Wang, X., Bartido, S. M., Park, J. H., Curran, K. J., Chung, S. S., Stefanski, J., Bórquez-Ojeda, O., Olszewska, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008226 · Cited by 2,484 · see citing works
Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
Neelapu, S. S., Tummala, S., Kebriaei, P., Wierda, W., Gutierrez, C., Locke, F. L., Komanduri, K. V., Lin, Y., Jain, N., Daver, N., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.148 · Cited by 2,438 · see citing works
Subcutaneous and visceral adipose tissue: Structural and functional differences
Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238 · see citing works
Peyrin‐Biroulet, L., Sandborn, W. J., Sands, B. E., Reinisch, W., Bemelman, W. A., Bryant, R. V., D’Haens, G., Dotan, I., Dubinsky, M. C., Feagan, B. G., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.233 · Cited by 1,843 · see citing works
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Schwartz, D. M., Kanno, Y., Villarino, A., Ward, M., Gadina, M., & O'Shea, J. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.201 · Cited by 1,266 · see citing works
Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19
Liu, F., Lin, L., Xu, M., Wu, J., Luo, D., Zhu, Y., Li, B., Song, X., & Zhou, X. P. (2020) · Journal of Clinical Virology · doi:10.1016/j.jcv.2020.104370 · Cited by 1,143 · see citing works
Bhutto, I. A., & Lutty, G. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.005 · Cited by 1,005 · see citing works
Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247452 · Cited by 1,017 · see citing works
Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules
Labib, M., Sargent, E. H., & Kelley, S. O. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00220 · Cited by 981 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Adipokines: molecular links between obesity and atheroslcerosis
Lau, D., Dhillon, B., Yan, H., Szmitko, P. E., & Verma, S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01058.2004 · Cited by 930 · see citing works
Research Progress on the Relationship between Atherosclerosis and Inflammation
Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., & Chen, R. (2018) · Biomolecules · doi:10.3390/biom8030080 · Cited by 877 · see citing works
Grundy, S. M., Hansen, B., Smith, S. C., Cleeman, J. I., Kahn, R. A., & Participants, F. C. (2004) · Circulation · doi:10.1161/01.cir.0000112379.88385.67 · Cited by 864 · see citing works
Buta, B. J., Walston, J. D., Godino, J., Park, M., Kalyani, R. R., Xue, Q., Bandeen‐Roche, K., & Varadhan, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.003 · Cited by 847 · see citing works
Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works
Acute phase proteins in dogs and cats: current knowledge and future perspectives
Cerón, J. M. C., Eckersall, P. D., & Martı́nez-Subiela, S. (2005) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.2005.tb00019.x · Cited by 830 · see citing works
Davidovici, B. B., Sattar, N. A., Prinz, J. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Ståhle, M., Nestle, F. O., Girolomoni, G., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.103 · Cited by 713 · see citing works
Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys, M. B., Hirschfield, G. M., Tennent, G. A., Ruth Gallimore, J., Kahan, M. C., Bellotti, V., Hawkins, P. N., Myers, R. M., Smith, M. D., Polara, A., et al. (2006) · Nature · doi:10.1038/nature04672 · Cited by 672 · see citing works
Self-citationAssociation of inflammatory markers with the severity of COVID-19: A meta-analysis
Zeng, F., Huang, Y., Guo, Y., Yin, M., Chen, X., Liang, X., & Deng, G. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.05.055 · Cited by 666 · see citing works
The role of defective clearance of apoptotic cells in systemic autoimmunity
Munoz, L. E., Lauber, K., Schiller, M. R., Manfredi, A. A., & i, M. H. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.46 · Cited by 625 · see citing works
Creswell, J. D., Irwin, M. R., Burklund, L. J., Lieberman, M. D., Arevalo, J. M. G., Ma, J., Breen, E. C., & Cole, S. W. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.006 · Cited by 607 · see citing works
An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm
Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101305 · Cited by 592 · see citing works
The importance of early brain injury after subarachnoid hemorrhage
Sehba, F. A., Hou, J. C.-T., Pluta, R. M., & Zhang, J. H. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.02.003 · Cited by 573 · see citing works
Buckley, D., Fu, R. F., Freeman, M., Rogers, K. R., & Helfand, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-7-200910060-00009 · Cited by 557 · see citing works
Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer
Allin, K. H., & Nordestgaard, B. G. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.599831 · Cited by 555 · see citing works
Causes and Metabolic Consequences of Fatty Liver
Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 529 · see citing works
Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response
Lin, Y., Jiang, M. H., Chen, W., Zhao, T., & Wei, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109249 · Cited by 505 · see citing works
High-Sensitivity C-Reactive Protein and Cardiovascular Disease
Yousuf, O. K., Mohanty, B. D., Martin, S. S., Joshi, P. H., Blaha, M. J., Nasir, K., Blumenthal, R. S., & Budoff, M. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.016 · Cited by 495 · see citing works
Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation
Rodríguez-Hernández, H., Simental‐Mendía, L. E., Ramírez, G. R., & Reyes-Romero, M. A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/678159 · Cited by 484 · see citing works
Hepatocytes: a key cell type for innate immunity
Zhou, Z., Xu, M.-J., & Gao, B. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.97 · Cited by 472 · see citing works
Inflammation as a psychophysiological biomarker in chronic psychosocial stress
Hänsel, A., Hong, S., Cámara, R. J. A., & von Känel, R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.012 · Cited by 458 · see citing works
Inflammation and pre-eclampsia
Borzychowski, A. M., Sargent, I. L., & Redman, C. W. G. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.04.001 · Cited by 457 · see citing works
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453 · see citing works
Use of Plasma Biomarkers at Exacerbation of Chronic Obstructive Pulmonary Disease
Hurst, J. R., Donaldson, G. C., Perera, W. R., Wilkinson, T. M. A., Bilello, J. A., Hagan, G. W., Vessey, R., & Wedzicha, J. A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-506oc · Cited by 453 · see citing works
<i><i>Bifidobacterium infantis</i></i>35624 modulates host inflammatory processes beyond the gut
Groeger, D., O’Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2013) · Gut Microbes · doi:10.4161/gmic.25487 · Cited by 448 · see citing works
Inflammation and cerebral small vessel disease: A systematic review
Low, A., Mak, E., Rowe, J. B., Markus, H. S., & O'Brien, J. T. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100916 · Cited by 445 · see citing works
Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3
Mantovani, A., Garlanda, C., Doni, A., & Bottazzi, B. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9126-7 · Cited by 440 · see citing works
Pathogenic Gut Flora in Patients With Chronic Heart Failure
Pasini, E., Aquilani, R., Testa, C., Baiardi, P., Angioletti, S., Boschi, F., Verri, M., & Dioguardi, F. S. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.10.009 · Cited by 440 · see citing works
ER stress-induced inflammation: does it aid or impede disease progression?
Garg, A. D., Kaczmarek, A., Krysko, O., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.010 · Cited by 418 · see citing works
Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer
Allin, K. H., Bojesen, S. E., & Nordestgaard, B. G. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.8440 · Cited by 419 · see citing works
Regulation of leukocyte recruitment by the long pentraxin PTX3
Deban, L., Russo, R. C., Sironi, M., Moalli, F., Scanziani, M., Zambelli, V., Cuccovillo, I., Bastone, A., Gobbi, M., Valentino, S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1854 · Cited by 418 · see citing works
Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis
Li, Y., Zhong, X., Cheng, G., Zhao, C., Zhang, L., Hong, Y., Wan, Q., He, R., & Wang, Z. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.02.003 · Cited by 419 · see citing works
Inflammation in the genesis and perpetuation of atrial fibrillation
Engelmann, M. D. M., & Svendsen, J. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi350 · Cited by 419 · see citing works
Jones, J., Loftus, E. V., Panaccione, R., Chen, L., Peterson, S. E., McConnell, J. P., Baudhuin, L. M., Hanson, K., Feagan, B. G., Harmsen, S. W., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.06.010 · Cited by 414 · see citing works
Inflammation, a Link between Obesity and Cardiovascular Disease
Wang, Z., & Nakayama, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/535918 · Cited by 413 · see citing works
Inflammatory Bowel Disease Presentation and Diagnosis
Flynn, S. M., & Eisenstein, S. G. (2019) · Surgical Clinics of North America · doi:10.1016/j.suc.2019.08.001 · Cited by 401 · see citing works
Luan, Y., & Yao, Y.-M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01302 · Cited by 396 · see citing works
Singh, P. P., Zeng, I. S. L., Srinivasa, S., Lemanu, D. P., Connolly, A. B., & Hill, A. G. (2013) · British journal of surgery · doi:10.1002/bjs.9354 · Cited by 388 · see citing works
Watt, D. G., Horgan, P. G., & McMillan, D. C. (2015) · Surgery · doi:10.1016/j.surg.2014.09.009 · Cited by 387 · see citing works
Dandona, P., Dhindsa, S., Ghanim, H., & Chaudhuri, A. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002101 · Cited by 384 · see citing works
C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice
Paul, A., Ko, K. W. S., Li, L., Yechoor, V. K., McCrory, M. A., Szalai, A. J., & Chan, L. (2004) · Circulation · doi:10.1161/01.cir.0000114526.50618.24 · Cited by 373 · see citing works
C‐reactive protein and coronary heart disease: a critical review
Casas, J. P., Shah, T., Hingorani, A. D., Danesh, J., & Pepys, M. B. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02015.x · Cited by 365 · see citing works
Self-citationSingh, S., Grabner, A., Yanucil, C., Schramm, K. J., Czaya, B. A., Krick, S., Czaja, M. J., Bartz, R., Abraham, R., Marco, G. S. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.019 · Cited by 361 · see citing works
Transfusion-associated circulatory overload and transfusion-related acute lung injury
Semple, J. W., Rebetz, J., & Kapur, R. (2019) · Blood · doi:10.1182/blood-2018-10-860809 · Cited by 358 · see citing works
2007 ESH‐ESC Guidelines for the management of arterial hypertension
Mansia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Blood Pressure · doi:10.1080/08037050701461084 · Cited by 358 · see citing works
Elevated level of C‐reactive protein may be an early marker to predict risk for severity of COVID‐19
Ali, N. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26097 · Cited by 365 · see citing works
Daneshkhah, A., Agrawal, V., Eshein, A., Subramanian, H., Roy, H. K., & Backman, V. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01677-y · Cited by 358 · see citing works
Effects of Fluticasone on Systemic Markers of Inflammation in Chronic Obstructive Pulmonary Disease
Sin, D. D., Lacy, P., York, E. L., & Man, S. F. P. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200404-543oc · Cited by 346 · see citing works
C-reactive protein and the biology of disease
Ansar, W., & Ghosh, S. (2013) · Immunologic Research · doi:10.1007/s12026-013-8384-0 · Cited by 337 · see citing works
Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction
Salio, M., Chimenti, S., Angelis, N. D., Molla, F., Maina, V., Nebuloni, M., Pasqualini, F., Latini, R., Garlanda, C., & Mantovani, A. (2008) · Circulation · doi:10.1161/circulationaha.107.749234 · Cited by 326 · see citing works
C-reactive protein, inflammation and coronary heart disease
Shrivastava, A. K., Singh, H. V., Raizada, A., & Singh, S. K. (2014) · The Egyptian Heart Journal · doi:10.1016/j.ehj.2014.11.005 · Cited by 321 · see citing works
Plasma CRP level is positively associated with the severity of COVID-19
Chen, W., Zheng, K. I., Liu, S., Yan, Z., Xu, C., & Qiao, Z. (2020) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-020-00362-2 · Cited by 323 · see citing works
C-reactive protein and implications in rheumatoid arthritis and associated comorbidities
Pope, J. E., & Choy, E. H. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.11.005 · Cited by 320 · see citing works
Koenig, W. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.113 · Cited by 315 · see citing works
Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1203 · Cited by 312 · see citing works
Inflammatory Biomarkers and Risk of Schizophrenia
Hartwig, F. P., Borges, M. C., Horta, B. L., Bowden, J., & Smith, G. D. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3191 · Cited by 299 · see citing works
Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses
Crispi, F., Hernandez‐Andrade, E. A., Pelsers, M. M. A. L., Plasencia, W., Benavides-Serralde, J. A., Eixarch, E., le Noble, F. A. C., Ahmed, A., Glatz, J. F. C., Nicolaides, K. H., et al. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.06.056 · Cited by 297 · see citing works
C-reactive protein levels and clinically important predictive outcomes in stable COPD patients
de-Torres, J. P., Córdoba-Lanús, E., López-Aguilar, C., de Fuentes, M. M., de Garcini, A. M., Aguirre‐Jaime, A., Celli, B. R., & Casanova, C. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00109605 · Cited by 297 · see citing works
Nazmi, A., & Victora, C. G. (2007) · BMC Public Health · doi:10.1186/1471-2458-7-212 · Cited by 291 · see citing works
Sohail, M. U., Ijaz, A., Yousaf, M. S., Ashraf, K., Zaneb, H., Aleem, M., & Rehman, H. (2010) · Poultry Science · doi:10.3382/ps.2010-00751 · Cited by 289 · see citing works
Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke
Napoli, M. D., Schwaninger, M., Cappelli, R., Ceccarelli, E., Gianfilippo, G. D., Donati, C., Emsley, H. C. A., Forconi, S., Hopkins, S. J., Masotti, L., et al. (2005) · Stroke · doi:10.1161/01.str.0000165929.78756.ed · Cited by 288 · see citing works
Savoia, C., & Schiffrin, E. L. (2006) · Current Opinion in Internal Medicine · doi:10.1097/01.mnh.0000203189.57513.76 · Cited by 286 · see citing works
The Influence of Exercise Training on Inflammatory Cytokines and C-Reactive Protein
STEWART, L. K., FLYNN, M. G., CAMPBELL, W. W., CRAIG, B. A., ROBINSON, J. P., TIMMERMAN, K. L., MCFARLIN, B. K., COEN, P. M., & TALBERT, E. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31811ece1c · Cited by 283 · see citing works
Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians
Markanday, A. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv098 · Cited by 281 · see citing works
Periodontal disease and C‐reactive protein‐associated cardiovascular risk
D’Aiuto, F., Ready, D. R., & Tonetti, M. S. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00731.x · Cited by 281 · see citing works
Tan, M., Lü, Y., Jiang, H., & Zhang, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27870 · Cited by 278 · see citing works
Hingorani, A. D., & Humphries, S. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67767-7 · Cited by 277 · see citing works
Shrotriya, S., Walsh, D., Bennani-Baiti, N., Thomas, S., & Lorton, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143080 · Cited by 277 · see citing works
Jeannin, P., Bottazzi, B., Sironi, M., Doni, A., Rusnati, M., Presta, M., Maina, V., Magistrelli, G., Haeuw, J. F., Hoeffel, G., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.008 · Cited by 276 · see citing works
Eisenhardt, S. U., Habersberger, J., Murphy, A. J., Chen, Y., Woollard, K. J., Bassler, N., Qian, H., Mühlen, C. V. Z., Hagemeyer, C. E., Ahrens, I., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.190611 · Cited by 272 · see citing works
Cordemans, C., laet, I. D., Regenmortel, N. V., Schoonheydt, K., Dits, H., Huber, W., & Malbrain, M. L. N. G. (2012) · Annals of Intensive Care · doi:10.1186/2110-5820-2-s1-s1 · Cited by 272 · see citing works
Agrawal, M., Spencer, E. A., Colombel, J., & Ungaro, R. C. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.04.063 · Cited by 272 · see citing works
Positive affect and psychobiological processes
Dockray, S., & Steptoe, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.006 · Cited by 263 · see citing works
The natural history of chronic obstructive pulmonary disease
Mannino, D. M., Watt, G. C. M., Hole, D. J., Gillis, C. R., Hart, C., McConnachie, A., Smith, G. D., Upton, M. N., Hawthorne, V. M., Sin, D. D., et al. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00024605 · Cited by 262 · see citing works
Computational identification of gene–social environment interaction at the human <i>IL6</i> locus
Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256 · see citing works
Ranneh, Y., Ali, F., Akim, A. M., Hamid, H. A., Khaza’ai, H., & Fadel, A. (2017) · Applied Biological Chemistry · doi:10.1007/s13765-017-0285-9 · Cited by 258 · see citing works
Pentraxins: structure, function, and role in inflammation.
du Clos, T. W. (2013) · ISRN Inflammation · doi:10.1155/2013/379040 · Cited by 96 · see citing works
The Anti-Inflammatory Effects of Testosterone
Bianchi, V. E. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00186 · Cited by 253 · see citing works
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity
Lesterhuis, W. J., Bosco, A., Millward, M., SMALL, M. P., Nowak, A. K., & Lake, R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.233 · Cited by 239 · see citing works
Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H., & Amer, S. A. K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052734 · Cited by 251 · see citing works
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
Ortega-Prieto, A. M., Skelton, J. K., Wai, S. N., Large, E., Lussignol, M., Vizcay-Barrena, G., Hughes, D., Fleck, R. A., Thursz, M., Catanese, M. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02969-8 · Cited by 236 · see citing works
Chait, A., Han, C. Y., Oram, J. F., & Heinecke, J. W. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400017-jlr200 · Cited by 230 · see citing works
Soltani, S., Chitsazi, M. J., & Salehi‐Abargouei, A. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.02.018 · Cited by 223 · see citing works
Acute Phase Proteins in Animals
Cray, C. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00005-6 · Cited by 228 · see citing works
- Authors
- Pepys, M. B., & Hirschfield, G. M.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Pepys, Mark B.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-06-15
- Volume
- 111
- Issue
- 12
- Pages
- 1805-1812
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4232045253
- Cited by
- 3,436
- References
- 55
- Citations by year
- 2026: 188 · 2025: 161 · 2024: 149 · 2023: 198 · 2022: 247 · 2021: 210 · 2020: 218 · 2019: 192 · 2018: 179 · 2017: 178 · 2016: 154 · 2015: 165 · 2014: 163 · 2013: 130 · 2012: 141
- FWCI
- 24.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Funders
- Wellcome Trust
- Wolfson Foundation
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- C-reactive protein, acute phase response, inflammation, serum biomarkers, innate immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review