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Cited by 438

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

Open access
Chambers, John C., Eda, Shinichi, Bassett, Paul, Karim, Yusuf, Thompson, Simon G., Gallimore, J.Ruth, Pepys, Mark B., Kooner, Jaspal S.·2001·Circulation
DOI 10.1161/01.cir.104.2.145
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Abstract

Background — Indian Asians in the United Kingdom have increased coronary heart disease (CHD) mortality compared with European whites, but the causes are not well understood. Increased circulating concentrations of C-reactive protein (CRP) are an independent risk factor for CHD. Therefore, we investigated this marker of inflammation in healthy UK Indian Asian and European white men. Methods and Results — We measured serum CRP concentrations and conventional CHD risk factors in 1025 healthy male subjects (518 Indian Asians and 507 European whites) aged 35 to 60 years who were recruited at random from general practitioner lists. The geometric mean CRP concentration was 17% higher (95% confidence interval, 3% to 33%) in Indian Asians compared with European whites. CRP values were strongly associated with conventional CHD risk factors, measures of obesity, and metabolic disturbances associated with insulin resistance in both racial groups. The difference in CRP concentrations between Indian Asians and European whites remained after adjustment for conventional CHD risk factors but was eliminated by an adjustment for central obesity and insulin resistance score in Asians. On the basis of these results, we estimate that the processes underlying elevated CRP and/or increased CRP production itself are associated with an ≈14% increase in population CHD risk among Indian Asians compared with European whites. Conclusions — CRP concentrations are higher in healthy Indian Asians than in European whites and are accounted for by greater central obesity and insulin resistance in Indian Asians. Our results suggest that inflammation or other mechanisms underlying elevated CRP values may contribute to the increased CHD risk among Indian Asians.

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Metadata

Authors
Chambers, J. C., Eda, S., Bassett, P., Karim, Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., & Kooner, J. S.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-07-10
Volume
104
Issue
2
Pages
145-150
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.104.2.145
OpenAlex
W2112157432
Cited by
438
References
35
FWCI
21.39
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites. https://app.cochat.ai/papers/10.1161/01.cir.104.2.145
The paper
Chambers, J. C., Eda, S., Bassett, P., Karim, Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., & Kooner, J. S. (2001). C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites. Circulation. https://doi.org/10.1161/01.cir.104.2.145

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.