Cited by 371Cardiovascular Health and Risk FactorsLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Risk factors and atherosclerotic lesions. A review of autopsy studies

Open access
Solberg, L A, Strong, J P·1983·Arteriosclerosis: An Official Journal of the American Heart Association, Inc.

Abstract

This review assesses the current status of knowledge concerning the relationship of risk factors to atherosclerotic lesions. Risk factors for atherosclerotic lesions per se need not necessarily be identical to those related to clinically overt coronary heart disease (CHD). This review is based on 1) autopsy studies where information risk factors was gathered in a retrospective fashion; and 2) autopsy studies where information on risk factors was gathered prospectively. In spite of differences in study designs and grading methods among the studies, the general findings were similar. Elevated serum cholesterol and blood pressure are positively and significantly related to atherosclerotic lesions. High density lipoprotein cholesterol is inversely related to coronary and probably also to cerebral atherosclerosis. Almost all studies indicate a significant association between cigarette smoking and degree of aortic atherosclerosis; a positive relationship between smoking and coronary atherosclerosis is found between obesity or physical activity and the degree of atherosclerosis. Data from the Community Pathology Study in New Orleans indicate that the average extent of coronary atherosclerosis in a population may be subject to changes within a relatively short period of time; these changes might be expected to parallel changes in risk factors in the population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.atv.3.3.187

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 6

  1. [5]5. Guzman MA, McMahan CA, McGIII HC Jr et al. Selected methodological aspects of the International Atherosclerosis Project. Lab Invest 1968;18:479-497
  2. [14]14. Solberg LA, McGarry PA. Cerebral atherosclerosis in per- sons wtth selected diseases. Lab Invest 1968;18:613-619
  3. [17]17. Zdanov VS, Vlhert AM. Atherosclerosis and diabetes melli- tus. Bull WHO 1976;53:547-554
  4. [30]30. Bekhert S, Fletcher E. The effects of smoking on myocardi- um conduction in the human heart. Am Heart J 1976;91:712- 720
  5. [33]33. Gotto AM Jr, Smith LC, Allen B, eds. Atherosclerosis V. New York: Springer-Verlag, 1980:57-62
  6. [47]47. Cooper R, Stamler J, Dyer A, Carside D. The decline in mortality from coronary heart disease, USA, 1968-1975. J Chronic Dis 1978;31:709-720

Cited by

Sorted by citations

Authors
Solberg, L. A., & Strong, J. P.
Affiliations
Oslo University Hospital (NO)
Venue
Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Published
1983-05
Volume
3
Issue
3
Pages
187-198
ISSN
0276-5047 (ISSN-L)
OpenAlex
W2168514834
Cited by
371
References
47
Citations by year
2026: 2 · 2025: 5 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 11
FWCI
2.37
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis An Official Journal of the American Heart Association Inc (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (HL-08974)
  • U.S. Public Health Service
  • National Heart, Lung, and Blood Institute (HL08974)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
atherosclerosis, cardiovascular risk factors, coronary artery disease, serum cholesterol, blood pressure, HDL cholesterol, cigarette smoking, obesity, physical activity, aortic atherosclerosis, cerebral atherosclerosis, autopsy studies
MeSH terms
Adult, Aged, Aorta, Arteriosclerosis, Autopsy, Cerebral Arteries, Cholesterol, Coronary Disease, Coronary Vessels, Diastole, Female, Humans, Hypertension, Lipoproteins, HDL, Cholesterol, HDL, Louisiana, Male, Middle Aged, Norway, Risk, Sex Factors, Smoking, Systole, Triglycerides, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review