Cited by 371Cardiovascular Health and Risk FactorsLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

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Risk factors and atherosclerotic lesions. A review of autopsy studies

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Solberg, L A, Strong, J P·1983·Arteriosclerosis: An Official Journal of the American Heart Association, Inc.

DOI 10.1161/01.atv.3.3.187

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Abstract

This review assesses the current status of knowledge concerning the relationship of risk factors to atherosclerotic lesions. Risk factors for atherosclerotic lesions per se need not necessarily be identical to those related to clinically overt coronary heart disease (CHD). This review is based on 1) autopsy studies where information risk factors was gathered in a retrospective fashion; and 2) autopsy studies where information on risk factors was gathered prospectively. In spite of differences in study designs and grading methods among the studies, the general findings were similar. Elevated serum cholesterol and blood pressure are positively and significantly related to atherosclerotic lesions. High density lipoprotein cholesterol is inversely related to coronary and probably also to cerebral atherosclerosis. Almost all studies indicate a significant association between cigarette smoking and degree of aortic atherosclerosis; a positive relationship between smoking and coronary atherosclerosis is found between obesity or physical activity and the degree of atherosclerosis. Data from the Community Pathology Study in New Orleans indicate that the average extent of coronary atherosclerosis in a population may be subject to changes within a relatively short period of time; these changes might be expected to parallel changes in risk factors in the population.

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Authors: Solberg, L. A., & Strong, J. P.
Affiliations: Oslo University Hospital (NO)
Venue: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1983-05
Volume: 3
Issue: 3
Pages: 187-198
ISSN: 0276-5047 (ISSN-L)
DOI: 10.1161/01.atv.3.3.187
OpenAlex: W2168514834
Cited by: 371
References: 47
Citations by year: 2026: 2 · 2025: 5 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 11
FWCI: 2.37
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis An Official Journal of the American Heart Association Inc (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (HL-08974)
U.S. Public Health Service
National Heart, Lung, and Blood Institute (HL08974)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: atherosclerosis, cardiovascular risk factors, coronary artery disease, serum cholesterol, blood pressure, HDL cholesterol, cigarette smoking, obesity, physical activity, aortic atherosclerosis, cerebral atherosclerosis, autopsy studies
MeSH terms: Adult, Aged, Aorta, Arteriosclerosis, Autopsy, Cerebral Arteries, Cholesterol, Coronary Disease, Coronary Vessels, Diastole, Female, Humans, Hypertension, Lipoproteins, HDL, Cholesterol, HDL, Louisiana, Male, Middle Aged, Norway, Risk, Sex Factors, Smoking, Systole, Triglycerides, Diabetes Complications

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