The DOI matches its Crossref record, with a small difference in title or year; 36 of the 36 references it cites were found in a registry or an index.
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction: Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
Abstract
Background — Our purpose was to assess the time course of the benefit of n-3 polyunsaturated fatty acids (PUFAs) on mortality documented by the GISSI-Prevenzione trial in patients surviving a recent (<3 months) myocardial infarction. Methods and Results — In this study, 11 323 patients were randomly assigned to supplements of n-3 PUFAs, vitamin E (300 mg/d), both, or no treatment (control) on top of optimal pharmacological treatment and lifestyle advice. Intention-to-treat analysis adjusted for interaction between treatments was carried out. Early efficacy of n-3 PUFA treatment for total, cardiovascular, cardiac, coronary, and sudden death; nonfatal myocardial infarction; total coronary heart disease; and cerebrovascular events was assessed by right-censoring follow-up data 12 times from the first month after randomization up to 12 months. Survival curves for n-3 PUFA treatment diverged early after randomization, and total mortality was significantly lowered after 3 months of treatment (relative risk [RR] 0.59; 95% CI 0.36 to 0.97; P =0.037). The reduction in risk of sudden death was specifically relevant and statistically significant already at 4 months (RR 0.47; 95% CI 0.219 to 0.995; P =0.048). A similarly significant, although delayed, pattern after 6 to 8 months of treatment was observed for cardiovascular, cardiac, and coronary deaths. Conclusions — The early effect of low-dose (1 g/d) n-3 PUFAs on total mortality and sudden death supports the hypothesis of an antiarrhythmic effect of this drug. Such a result is consistent with the wealth of evidence coming from laboratory experiments on isolated myocytes, animal models, and epidemiological and clinical studies.
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“contemporary high-intensity statin formulations achieve greater low-density lipoprotein–lowering effects and cardiovascular endpoint reduction than were used during the first mixed EPA/DHA trials, such as GISSI-P.17,27,44”
From Effects of Eicosapentaenoic Acid vs Eicosapentaenoic/Docosahexaenoic Acids on Cardiovascular Mortality (2025) · cites this paper as [44]
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“Data from meta-analyses suggest that a reduction of calculated glomerular filtration rate (GFR) does not reflect any adverse effects on kidney function [315].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [315]
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“Results from other meta-analyses suggest reduced major CVD events in patients with high TGs and low HDL-C in fibrate-treated patients, but no decrease in CVD or total mortality [314-316].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [315]
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“A post hoc subgroup analysis revealed that this reduction in mortality and SCD was concentrated in the approximately 2000 patients with reduced left ventricular ejection fraction [67].”
From Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health (2022) · cites this paper as [67]
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Citations
Cites
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177
(1999) · PubMed · Cited by 2,062
Self-citationn-3 fatty acids and serum lipoproteins: human studies
Harris, W. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1645s · Cited by 1,243
Fish Consumption and Risk of Sudden Cardiac Death
Albert, C. M. (1998) · JAMA · doi:10.1001/jama.279.1.23 · Cited by 990
The Composition of Food Consumed by Greenland Eskimos
Bang, H. O., Dyerberg, J., & Hjørne, N. (1976) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1976.tb08198.x · Cited by 950
Siscovick, D. S. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530170043030 · Cited by 920
Fish consumption and the 30-year risk of fatal myocardial infarction
Daviglus, M. L., Stamler, J., Orencia, A. J., Dyer, A. R., Liu, K., Greenland, P., Walsh, M. K., Morris, D., & Shekelle, R. B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361502 · Cited by 902
Kromann, N., & Green, A. (1980) · PubMed · Cited by 854
Kromann, N., & Green, A. (1980) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1980.tb01221.x · Cited by 713
Analysing Survival Data From Clinical Trials and Observational Studies
(1996) · Technometrics · doi:10.1080/00401706.1996.10484530 · Cited by 666
Pietinen, P., Ascherio, A., Korhonen, P. A., Hartman, A. M., Willett, W. C., Albanes, D., & Virtamo, J. R. K. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009047 · Cited by 560
Dietary Intake of Marine n-3 Fatty Acids, Fish Intake, and the Risk of Coronary Disease among Men
Ascherio, A., Rimm, E. B., Stampfer, M. J., Giovannucci, E. L., & Willett, W. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321501 · Cited by 543
Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V., & Moshiri, M. (1997) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1007757724505 · Cited by 537
The Effect of Dietary ω-3 Fatty Acids on Coronary Atherosclerosis
von Schacky, C., Angerer, P., Kothny, W., Theisen, K., & Mudra, H. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-7-199904060-00003 · Cited by 486
Singh, R. B., Rastogi, S. S., Verma, R. K., Laxmi, B. V., Singh, R. B., Ghosh, S., & Niaz, M. A. (1992) · BMJ · doi:10.1136/bmj.304.6833.1015 · Cited by 457
Dolecek, T. A. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-200-43413 · Cited by 410
Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs
Billman, G. E., Kang, J. X., & Leaf, A. (1999) · Circulation · doi:10.1161/01.cir.99.18.2452 · Cited by 393
A clinical appraisal of left atrial function
Stefanadis, C. (2001) · European Heart Journal · doi:10.1053/euhj.1999.2581 · Cited by 282
Antiarrhythmic Effects of Polyunsaturated Fatty Acids
Kang, J. X., & Leaf, A. (1996) · Circulation · doi:10.1161/01.cir.94.7.1774 · Cited by 227
Christensen, J. H., Korup, E., Aarøe, J., Toft, E. S., Møller, J., Rasmussen, K., Dyerberg, J., & Schmidt, E. B. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00220-8 · Cited by 185
Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey
McLennan, P. L., Bridle, T. M., Abeywardena, M. Y., & Charnock, J. S. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90809-a · Cited by 182
Fauchier, L., Babuty, D., Cosnay, P., & Fauchier, J. P. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00021-2 · Cited by 159
Rodríguez, B. L., Sharp, D. S., Abbott, R. D., Burchfiel, C. M., Masaki, K., Chyou, P., Huang, B., Yano, K., & Curb, J. D. (1996) · Circulation · doi:10.1161/01.cir.94.5.952 · Cited by 131
Marchioli, R. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2544 · Cited by 127
Self-citationEffects of dietary fish oil on ventricular premature complexes
Sellmayer, A., Witzgall, H., Lorenz, R. L., & Weber, P. C. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80276-8 · Cited by 123
The 2 × 2 factorial design: Its application to a randomized trial of aspirin and U.S. physicians
Stampfer, M. J., Buring, J. E., Willett, W. C., ROSNER, B. A., Eberlein, K. A., & Hennekens, C. H. (1985) · Statistics in Medicine · doi:10.1002/sim.4780040202 · Cited by 120
n-3 fatty acids and serum lipoproteins: animal studies
Harris, W. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1611s · Cited by 113
Omega-3 fatty acids in the prevention-management of cardiovascular disease.
Simopoulos, A. P. (1997) · PubMed · Cited by 109
Factorial designs for randomized clinical trials.
Byar, D. P., & Piantadosi, S. (1985) · PubMed · Cited by 85
n-3 fatty acids and ventricular extrasystoles in patients with ventricular tachyarrhythmias
Christensen, J. H., Gustenhoff, P., Ejlersen, E., Jessen, T. E., Korup, E., Rasmussen, K., Dyerberg, J., & Schmidt, E. B. (1995) · Nutrition Research · doi:10.1016/0271-5317(95)91647-u · Cited by 44
Marchioli, R. (2001) · European Heart Journal Supplements · doi:10.1016/s1520-765x(01)90126-9 · Cited by 27
Self-citationThe results of the GISSI-Prevenzione trial in the general framework of secondary prevention
Marchioli, R. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1971 · Cited by 26
Self-citationBiochemistry and physiology of eicosanoid precursors in cell membranes
Lands, W. (2001) · European Heart Journal Supplements · doi:10.1016/s1520-765x(01)90114-2 · Cited by 8
Research works printed but not linked: 10
Cited by
Sorted by citations
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
Metadata
- Authors
- Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., Franzosi, M. G., Geraci, E., Levantesi, G., Maggioni, A. P., Mantini, L., Marfisi, R. M., Mastrogiuseppe, G., Mininni, N., Nicolosi, G. L., Santini, M., Schweiger, C., Tavazzi, L., Tognoni, G., Tucci, C., & Valagussa, F.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- From the Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti (R.M., F.B., E.B., R.D.M., R.M.M., G.T.); Ospedale Civile, Caserta (C.C.); Ospedale Civile, Lanciano (D.D.G., L.M., G.M., C.T.); Department of Cardiovascular Research, Istituto Mario Negri, Milano (M.G.F.); Ospedale Cervello, Palermo (E.G.); Ospedale Civile, Vasto (G.L.); Centro Studi ANMCO, Firenze (A.P.M.); Ospedale Civile, Napoli (N.M.); Ospedale S. Maria degli Angeli, Pordenone (G...
- Corresponding author
- Marchioli, Roberto
- Venue
- Circulation
- Published
- 2002-04-23
- Volume
- 105
- Issue
- 16
- Pages
- 1897-1903
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2128788220
- Cited by
- 1,311
- References
- 36
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 27 · 2023: 18 · 2022: 21 · 2021: 17 · 2020: 30 · 2019: 20 · 2018: 33 · 2017: 42 · 2016: 42 · 2015: 49 · 2014: 64 · 2013: 87 · 2012: 84
- FWCI
- 60.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Istituto di Ricerche Farmacologiche Mario Negri - IRCCS
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- omega-3 fatty acids, myocardial infarction, sudden death, mortality, vitamin E, antiarrhythmic effect, time course of treatment effects, cardiovascular mortality, coronary artery disease, cerebrovascular events
- MeSH terms
- Anti-Arrhythmia Agents, Female, Follow-Up Studies, Humans, Italy, Kinetics, Lipids, Male, Middle Aged, Myocardial Infarction, Fatty Acids, Omega-3, Death, Sudden, Cardiac, Dietary Supplements
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