The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Exercise-Induced Increase in Baroreflex Sensitivity Predicts Improved Prognosis After Myocardial Infarction
Open accessAbstract
Background— Despite the rational expectation for a survival benefit produced by exercise training among post–myocardial infarction (MI) patients, direct evidence remains elusive. Clinically, changes in autonomic balance toward lower vagal activity have consistently been associated with increased mortality risk; conversely, among both control and post-MI dogs, exercise training improved vagal reflexes and prevented sudden death. Accordingly, we tested the hypothesis that exercise training, if accompanied by a shift toward increased vagal activity of an autonomic marker such as baroreflex sensitivity (BRS), could reduce mortality in post-MI patients. Methods and Results— Ninety-five consecutive male patients surviving a first uncomplicated MI were randomly assigned to a 4-week endurance training period or to no training. Age (51±8 versus 52±8 years), site of MI (anterior 41% versus 43%), left ventricular ejection fraction (52±13 versus 51±14%), and BRS (7.9±5.4 versus 7.9±3.4 ms/mm Hg) did not differ between the two groups. After 4 weeks, BRS improved by 26% ( P =0.04) in trained patients, whereas it did not change in nontrained patients. During a 10-year follow-up, cardiac mortality among the 16 trained patients who had an exercise-induced increase in BRS ≥3 ms/mm Hg (responders) was strikingly lower compared with that of the trained patients without such a BRS increase (nonresponders) and that of the nontrained patients (0 of 16 versus 18 of 79 [23%], P =0.04). Cardiac mortality was also lower among responders irrespective of training (4% versus 24%, P =0.04). Conclusions— Post-MI exercise training can favorably modify long-term survival, provided that it is associated with a clear shift of the autonomic balance toward an increase in vagal activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Kleiger, R. E., Miller, J. P., Bigger, J. T., & Moss, A. J. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90795-8 · Cited by 3,995
Heart-rate Recovery Immediately After Exercise as a Predictor of Mortality
Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411804 · Cited by 1,935
La Rovere, M. T., Pinna, G. D., Hohnloser, S. H., Marcus, F. I., Mortara, A., Nohara, R., Bigger, J. T., Camm, A. J., & Schwartz, P. J. (2001) · Circulation · doi:10.1161/01.cir.103.16.2072 · Cited by 697
Self-citationVanoli, E., De Ferrari, G. M., Stramba-Badiale, M., Hull, S. S., Foreman, R. D., & Schwartz, P. J. (1991) · Circulation Research · doi:10.1161/01.res.68.5.1471 · Cited by 681
Self-citationHull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D., & Schwartz, P. J. (1994) · Circulation · doi:10.1161/01.cir.89.2.548 · Cited by 299
Self-citationMalfatto, G., Facchini, M., Bragato, R., Branzi, G., Sala, L., & Leonetti, G. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014905 · Cited by 139
Cited by
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235
Exercise-based cardiac rehabilitation for coronary heart disease
Heran, B. S., Chen, J. M., Ebrahim, S., Moxham, T., Oldridge, N., Rees, K., Thompson, D. R., & Taylor, R. S. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001800.pub2 · Cited by 1,844
Lawler, P. R., Filion, K. B., & Eisenberg, M. J. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.07.017 · Cited by 701
Heart Rate Variability Biofeedback Increases Baroreflex Gain and Peak Expiratory Flow
Lehrer, P. M., Vaschillo, E., Vaschillo, B., Lu, S.-E., Eckberg, D. L., Edelberg, R., Shih, W. J., Lin, Y., Kuusela, T. A., Tahvanainen, K. U. O., et al. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000089200.81962.19 · Cited by 497
Exercise training restores baroreflex sensitivity in never-treated hypertensive patients
Laterza, M. C., de Matos, L. D. N. J., Trombetta, I. C., Braga, A. M. W., Roveda, F., Alves, M. J. N. N., Krieger, E. M., Negrão, C. E., & Rondon, M. U. P. B. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085548 · Cited by 299
Metadata
- Authors
- La Rovere, M. T., Bersano, C., Gnemmi, M., Specchia, G., & Schwartz, P. J.
- Venue
- Circulation
- Published
- 2002-08-20
- Volume
- 106
- Issue
- 8
- Pages
- 945-949
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2152502546
- Cited by
- 336
- References
- 7
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Exercise-Induced Increase in Baroreflex Sensitivity Predicts Improved Prognosis After Myocardial Infarction. https://app.cochat.ai/papers/10.1161/01.cir.0000027565.12764.e1
- The paper
- La Rovere, M. T., Bersano, C., Gnemmi, M., Specchia, G., & Schwartz, P. J. (2002). Exercise-Induced Increase in Baroreflex Sensitivity Predicts Improved Prognosis After Myocardial Infarction. Circulation. https://doi.org/10.1161/01.cir.0000027565.12764.e1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
