The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Importance of Cardiac Troponins I and T in Risk Stratification of Patients With Acute Pulmonary Embolism
Abstract
Background— Assessment of risk and appropriate management of patients with acute pulmonary embolism (PE) remains a challenge. Cardiac troponins I (cTnI) and T (cTnT) are reliable indicators of myocardial injury and may be associated with right ventricular dysfunction in PE. Methods and Results— The present prospective study included 106 consecutive patients with confirmed acute PE. cTnI was elevated (≥0.07 ng/mL) in 43 patients (41%), and cTnT (≥0.04 ng/mL) was elevated in 39 (37%). Elevation of cTnI or cTnT was significantly associated with echocardiographically detected right ventricular dysfunction ( P =0.001 and P <0.05, respectively). Moreover, a significant correlation was found between elevation of cTnI or cTnT and the two major end points overall mortality and complicated in-hospital course. The negative predictive value of cardiac troponins for major clinical events was 92% to 93%. Importantly, there was obvious escalation of in-hospital mortality, the rate of complications, and the incidence of recurrent PE, when patients with high troponin concentrations (cTnI >1.5; cTnT >0.1 ng/mL) were compared with those with only moderately elevated levels (cTnI, 0.07 to 1.5; cTnT, 0.04 to 0.1 ng/mL). Logistic regression analysis confirmed that the mortality risk (OR) was significantly elevated only in patients with high cTnI ( P =0.019) or cTnT ( P =0.038) levels. Furthermore, the risk of a complicated in-hospital course was almost 5 times higher (15.47 versus 3.16) in the high-cTnI group compared with patients with moderate cTnI elevation. Conclusions— Our results indicate that cTnI and cTnT may be a novel, particularly useful tool for optimizing the management strategy in patients with acute PE.
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Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1193 · Cited by 4,487
Goldhaber, S. Z., Visani, L., & De Rosa, M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07534-5 · Cited by 2,870
Cardiac troponin I. A marker with high specificity for cardiac injury.
Adams, J. E., Bodor, G. S., Dávila-Román, V. G., Delmez, J. A., Apple, F. S., Ladenson, J. H., & Jaffe, A. S. (1993) · Circulation · doi:10.1161/01.cir.88.1.101 · Cited by 1,148
Hamm, C. W., Goldmann, B. U., Heeschen, C., Kreymann, G., Berger, J., & Meinertz, T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712043372302 · Cited by 1,039
The Clinical Course of Pulmonary Embolism
Carson, J. L., Kelley, M. A., Duff, A., Weg, J. G., Fulkerson, W. J., Palevsky, H. I., Schwartz, J. S., Thompson, B. T., Popovich, J., Hobbins, T. E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205073261902 · Cited by 1,039
Kasper, W., Konstantinides, S., Geibel, A., Olschewski, M., Heinrich, F., Grosser, K. D., Rauber, K., Iversen, S., Redecker, M., & Kienast, J. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00319-7 · Cited by 1,034
Self-citationGrifoni, S., Olivotto, I., Cecchini, P., Pieralli, F., Camaiti, A., Santoro, G., Conti, A., Agnelli, G., & Berni, G. (2000) · Circulation · doi:10.1161/01.cir.101.24.2817 · Cited by 836
Diagnostic efficiency of troponin T measurements in acute myocardial infarction.
Katus, H. A., Remppis, A., Neumann, F. J., Scheffold, T., Diederich, K. W., Vinar, G., Noe, A., Matern, G., & Kuebler, W. (1991) · Circulation · doi:10.1161/01.cir.83.3.902 · Cited by 814
Morrow, D. A. (2001) · JAMA · doi:10.1001/jama.286.19.2405 · Cited by 656
Lindahl, B., Venge, P., & Wallentin, L. (1996) · Circulation · doi:10.1161/01.cir.93.9.1651 · Cited by 575
Cited by
Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119
Antithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830
Haddad, F., Hunt, S. A., Rosenthal, D. N., & Murphy, D. J. (2008) · Circulation · doi:10.1161/circulationaha.107.653576 · Cited by 1,523
Derivation and validation of a prognostic model for pulmonary embolism
Aujesky, D., Obrosky, D. S., Stone, R. A., Auble, T. E., Perrier, A., Cornuz, J., Roy, P.-M., & Fine, M. J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-862oc · Cited by 1,303
Troponin: the biomarker of choice for the detection of cardiac injury
Babuin, L., & Jaffe, A. S. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050141 · Cited by 686
Metadata
- Authors
- Konstantinides, S., Geibel, A., Olschewski, M., Kasper, W., Hruska, N., Jäckle, S., & Binder, L.
- Venue
- Circulation
- Published
- 2002-09-03
- Volume
- 106
- Issue
- 10
- Pages
- 1263-1268
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1976106457
- Cited by
- 447
- References
- 18
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Konstantinides, S., Geibel, A., Olschewski, M., Kasper, W., Hruska, N., Jäckle, S., & Binder, L. (2002). Importance of Cardiac Troponins I and T in Risk Stratification of Patients With Acute Pulmonary Embolism. Circulation. https://doi.org/10.1161/01.cir.0000028422.51668.a2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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