The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells
Open accessAbstract
Background— C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis. Methods and Results— We tested the effect of CRP on eNOS expression and bioactivity in cultured human aortic endothelial cells (HAECs). CRP decreased eNOS mRNA, protein abundance, and enzyme activity in HAECs. Furthermore, eNOS bioactivity assayed by cyclic GMP levels was significantly reduced by CRP. Preincubation of cells with CRP also significantly increased the adhesion of monocytes to HAECs. Conclusion— CRP causes a direct reduction in eNOS expression and bioactivity in HAECs, further supporting its role in atherogenesis.
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C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
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Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae
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Cited by
Black, S., Kushner, I., & Samols, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400025200 · Cited by 1,844
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Antiinflammatory Properties of HDL
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Endothelial Function: A Critical Determinant in Atherosclerosis?
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Metadata
- Authors
- Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P., & Jialal, I.
- Venue
- Circulation
- Published
- 2002-09-17
- Volume
- 106
- Issue
- 12
- Pages
- 1439-1441
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2039420330
- Cited by
- 853
- References
- 20
- FWCI
- 33.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P., & Jialal, I. (2002). Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells. Circulation. https://doi.org/10.1161/01.cir.0000033116.22237.f9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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