Cited by 168Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCoronary Interventions and Diagnostics

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Non–High-Density Lipoprotein Cholesterol Levels Predict Five-Year Outcome in the Bypass Angioplasty Revascularization Investigation (BARI)

Bittner, Vera, Hardison, Regina, Kelsey, Sheryl F., Weiner, Bonnie H., Jacobs, Alice K., Sopko, George·2002·Circulation

DOI 10.1161/01.cir.0000038496.57570.06

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Abstract

Background— Current National Cholesterol Education Program guidelines recommend that non–high-density lipoprotein cholesterol (non-HDL-C) be considered a secondary target of therapy among individuals with triglycerides >2.26 mmol/L. It is not known whether non-HDL-C relates to prognosis among patients with coronary heart disease. Methods and Results— Lipid levels were available at baseline among 1514 patients (73% men; mean age, 61 years) enrolled in the Bypass Angioplasty Revascularization Investigation (BARI); all had multivessel coronary artery disease. Patients were followed for 5 years. Outcomes of death, nonfatal myocardial infarction, and death or myocardial infarction were modeled using univariate and multivariate time-dependent proportional hazards methods; angina pectoris at 5 years was modeled using univariate and multivariate logistic regression. Non-HDL-C was a strong and independent predictor of nonfatal myocardial infarction (multivariate relative risk, 1.049 [95% confidence intervals, 1.006 to 1.093] for every 0.26 mmol/L increase) and angina pectoris (multivariate odds ratio, 1.049 [95% confidence intervals, 1.004 to 1.096] for every 0.26 mmol/L increase), but it did not relate to mortality. HDL-C and LDL-C did not predict events during follow-up. Conclusions— Among patients with lipid values in BARI, non-HDL-C is a strong and independent predictor of nonfatal myocardial infarction and angina pectoris at 5 years, even after consideration of powerful clinical variables. Our data suggest that non-HDL-C is an appropriate treatment target among patients with coronary heart disease.

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Authors: Bittner, V., Hardison, R., Kelsey, S. F., Weiner, B. H., Jacobs, A. K., & Sopko, G.
Affiliations: Boston University (US)
ORCID: Bittner, Vera
Weiner, Bonnie H.
Jacobs, Alice K.
Sopko, George
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-11-12
Volume: 106
Issue: 20
Pages: 2537-2542
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000038496.57570.06
OpenAlex: W2113541168
Cited by: 168
References: 16
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 13 · 2012: 4
FWCI: 9.86
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01hl038532-11, 5u01hl038504-10, 5u01hl038556-10, 5u01hl038512-10, 5u01hl038642-11, 2u01hl038514-09, 5u01hl038509-10, 5u01hl038518-11, 5u01hl038529-11, 2u01hl038524-09, 2u01hl038493-09)
National Heart, Lung, and Blood Institute (HL 38610, HL-38509, HL42145, HL-38529, HL38514-6, HL38556, HL-38493, HL-38532, HL38642, HL-38504, HL-38518, HL 38512, U01HL038610, HL38524)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
Keywords: non-HDL cholesterol, coronary artery disease, multivessel coronary artery disease, nonfatal myocardial infarction, angina pectoris, cardiovascular mortality, prognostic factors, triglycerides, HDL cholesterol, LDL cholesterol
MeSH terms: Angina Pectoris, Coronary Artery Bypass, Cholesterol, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Myocardial Infarction, Prognosis, Risk, Triglycerides, Angioplasty, Balloon, Coronary, Treatment Outcome

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Non–High-Density Lipoprotein Cholesterol Levels Predict Five-Year Outcome in the Bypass Angioplasty Revascularization Investigation (BARI)

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