Relative Atherogenicity and Predictive Value of Non–High-Density Lipoprotein Cholesterol for Coronary Heart Disease
Abstract
Although low-density lipoprotein cholesterol (LDL-C) is a well-established atherogenic factor for coronary heart disease, it does not completely represent the risk associated with atherogenic lipoproteins in the presence of high triglyceride (TG) levels. Constituent lipoproteins constituting non-high-density lipoprotein cholesterol (non-HDL-C) include atherogenic TG-rich lipoproteins, cholesteryl ester-enriched remnants of TG-rich lipoproteins, and lipoprotein(a). Recent observational and intervention studies suggest that the predictive value of non-HDL-C for cardiovascular risk and mortality is better than low-density lipoprotein cholesterol and that non-HDL-C correlates highly with plasma apolipoprotein B levels. Currently, the National Cholesterol Education Program Adult Treatment Panel III guidelines identify non-HDL-C as a secondary target of therapy in patients with TG elevation (> or =200 mg/dl) after the attainment of LDL-C target goals. In patients with coronary heart disease or coronary heart disease risk equivalents, an optional non-HDL-C goal is <100 mg/dl. To achieve the non-HDL-C goal, statin therapy may be intensified or combined with ezetimibe, niacin, a fibrate, or omega-3 fatty acids. In conclusion, non-HDL-C remains an important target of therapy for patients with elevated TGs, although its widespread adoption has yet to gain a foothold among health care professionals treating patients with dyslipidemia.
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The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, and this relationship has now been confirmed in many studies.
“The value of non-HDL-C in CVD risk assessment was first proposed by Frost and Havel in 1998, 61 and this relationship has now been confirmed in many studies. [203]3][204][205][206][207][208][209][210][211][212][213][214][215][216]”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [203]
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- Authors
- Miller, M., Ginsberg, H. N., & Schaefer, E. J.
- Affiliations
- University of Maryland Medical Center (US)
- Columbia University (US)
- Tufts University (US)
- Corresponding author
- Miller, Michael
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 101
- Issue
- 7
- Pages
- 1003-1008
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2027014777
- Cited by
- 102
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 12 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- non-HDL cholesterol, coronary artery disease, atherogenic lipoproteins, triglyceride-rich lipoproteins, lipoprotein(a), apolipoprotein B, cardiovascular risk prediction, dyslipidemia, statin therapy, ezetimibe, nicotinic acid, fibrates, omega-3 fatty acids, LDL cholesterol, NCEP ATP III guidelines, hypertriglyceridemia
- MeSH terms
- Apolipoproteins B, Coronary Disease, Humans, Cholesterol, LDL, Predictive Value of Tests, Triglycerides, Dyslipidemias, Atherosclerosis
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