CoChat
Sign Up
Cited by 557Cardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic DiseasesCardiovascular and exercise physiology

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Sympathetic Neural Activation in Visceral Obesity

Alvarez, Guy E., Beske, Stacy D., Ballard, Tasha P., Davy, Kevin P.·2002·Circulation
DOI 10.1161/01.cir.0000041244.79165.25
Open this paper in CoChat — free account

Abstract

Background— Muscle sympathetic nerve activity (MSNA) is elevated in obese humans. However, the potential role of abdominal visceral fat as an important adipose tissue depot linking obesity to elevated MSNA has not been explored. Accordingly, we tested the hypothesis that MSNA would be increased in men (age=18 to 40 years, body mass index ≤35 kg/m 2 ) with higher abdominal visceral fat (HAVF; n=13, abdominal visceral fat=118.1±15.8 cm 2 ) compared with their age- (28.7±2.4 versus 25.5±2.0 years, P >0.05), total fat mass-matched (20.6±2.1 versus 20.8±2.4 kg, P >0.05) and abdominal subcutaneous fat-matched (230.6±24.9 versus 261.4±34.8 cm 2 , P >0.05) peers with lower abdominal visceral fat levels (LAVF; n=13, visceral fat= 73.0±6.0 cm 2 ). Methods and Results— MSNA (microneurography), body composition (dual energy x-ray absorptiometry), and abdominal visceral and subcutaneous fat (computed tomography) were measured in 37 sedentary men across a wide range of adiposity. MSNA was ≈55% higher in men with HAVF compared with men with LAVF (33±4 versus 21±2 bursts/min, P <0.05). Furthermore, MSNA was more closely associated with the level of abdominal visceral fat ( r =0.65, P <0.05) than total fat mass ( r =0.323, P <0.05) or abdominal subcutaneous fat ( r =0.27, P =0.05). The relation between MSNA and abdominal visceral fat was independent of total body fat ( r =0.61, P <0.05). Conclusions— The results of our study indicate that MSNA is elevated in men with visceral obesity. Our observations are consistent with the idea that abdominal visceral fat is an important adipose tissue depot linking obesity with sympathetic neural activation in humans. Furthermore, these findings may have important implications for understanding the increased risk of developing cardiovascular diseases in individuals with visceral obesity.

Overview

Integrity signals

Registry

Crossref · 10.1161/01.cir.0000041244.79165.25

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 21 references

Research works printed but not linked: 10

  1. 10.1161/circ.96.9.3248 · DOI
  2. 1988, Diabetes, 607, 1595
  3. 10.1161/hyp.25.4.560 · DOI
  4. 10.1161/circ.97.20.2037 · DOI
  5. 10.1161/hyp.38.6.1316 · DOI
  6. 10.1161/circ.89.6.8205675 · DOI
  7. 10.1161/hyp.32.2.298 · DOI
  8. 1992, Am J Physiol, 262, H1372
  9. 2000, Int J Obes Relat Metab Disord, 24, S80
  10. 10.1161/circ.98.8.772 · DOI

Cited by

Sorted by citations

Items 501–556 of 556

Related

See all

Metadata

Authors
Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P.
Affiliations
University of Mississippi Medical Center (US)
ORCID
Davy, Kevin P.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-11-12
Volume
106
Issue
20
Pages
2533-2536
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000041244.79165.25
OpenAlex
W2138900790
Cited by
557
References
21
Citations by year
2026: 3 · 2025: 16 · 2024: 19 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 29 · 2015: 27 · 2014: 42 · 2013: 24 · 2012: 29
FWCI
11.84
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL62283, K02HL067227, R01HL062283, HL67227)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
visceral obesity, visceral fat, muscle sympathetic nerve activity, sympathetic activation, adipose tissue depots, subcutaneous adipose tissue, body composition, cardiovascular risk
MeSH terms
Adipose Tissue, Adolescent, Adult, Anthropometry, Body Composition, Humans, Male, Obesity, Sympathetic Nervous System, Baroreflex, Muscle, Skeletal, Abdominal Cavity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review