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Cited by 557Cardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic DiseasesCardiovascular and exercise physiology

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Sympathetic Neural Activation in Visceral Obesity

Alvarez, Guy E., Beske, Stacy D., Ballard, Tasha P., Davy, Kevin P.·2002·Circulation
DOI 10.1161/01.cir.0000041244.79165.25
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Abstract

Background— Muscle sympathetic nerve activity (MSNA) is elevated in obese humans. However, the potential role of abdominal visceral fat as an important adipose tissue depot linking obesity to elevated MSNA has not been explored. Accordingly, we tested the hypothesis that MSNA would be increased in men (age=18 to 40 years, body mass index ≤35 kg/m 2 ) with higher abdominal visceral fat (HAVF; n=13, abdominal visceral fat=118.1±15.8 cm 2 ) compared with their age- (28.7±2.4 versus 25.5±2.0 years, P >0.05), total fat mass-matched (20.6±2.1 versus 20.8±2.4 kg, P >0.05) and abdominal subcutaneous fat-matched (230.6±24.9 versus 261.4±34.8 cm 2 , P >0.05) peers with lower abdominal visceral fat levels (LAVF; n=13, visceral fat= 73.0±6.0 cm 2 ). Methods and Results— MSNA (microneurography), body composition (dual energy x-ray absorptiometry), and abdominal visceral and subcutaneous fat (computed tomography) were measured in 37 sedentary men across a wide range of adiposity. MSNA was ≈55% higher in men with HAVF compared with men with LAVF (33±4 versus 21±2 bursts/min, P <0.05). Furthermore, MSNA was more closely associated with the level of abdominal visceral fat ( r =0.65, P <0.05) than total fat mass ( r =0.323, P <0.05) or abdominal subcutaneous fat ( r =0.27, P =0.05). The relation between MSNA and abdominal visceral fat was independent of total body fat ( r =0.61, P <0.05). Conclusions— The results of our study indicate that MSNA is elevated in men with visceral obesity. Our observations are consistent with the idea that abdominal visceral fat is an important adipose tissue depot linking obesity with sympathetic neural activation in humans. Furthermore, these findings may have important implications for understanding the increased risk of developing cardiovascular diseases in individuals with visceral obesity.

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Crossref · 10.1161/01.cir.0000041244.79165.25

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Citations

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Research works printed but not linked: 10

  1. 10.1161/circ.96.9.3248 · DOI
  2. 1988, Diabetes, 607, 1595
  3. 10.1161/hyp.25.4.560 · DOI
  4. 10.1161/circ.97.20.2037 · DOI
  5. 10.1161/hyp.38.6.1316 · DOI
  6. 10.1161/circ.89.6.8205675 · DOI
  7. 10.1161/hyp.32.2.298 · DOI
  8. 1992, Am J Physiol, 262, H1372
  9. 2000, Int J Obes Relat Metab Disord, 24, S80
  10. 10.1161/circ.98.8.772 · DOI

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Metadata

Authors
Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P.
Affiliations
University of Mississippi Medical Center (US)
ORCID
Davy, Kevin P.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-11-12
Volume
106
Issue
20
Pages
2533-2536
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000041244.79165.25
OpenAlex
W2138900790
Cited by
557
References
21
Citations by year
2026: 3 · 2025: 16 · 2024: 19 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 29 · 2015: 27 · 2014: 42 · 2013: 24 · 2012: 29
FWCI
11.84
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL62283, K02HL067227, R01HL062283, HL67227)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
visceral obesity, visceral fat, muscle sympathetic nerve activity, sympathetic activation, adipose tissue depots, subcutaneous adipose tissue, body composition, cardiovascular risk
MeSH terms
Adipose Tissue, Adolescent, Adult, Anthropometry, Body Composition, Humans, Male, Obesity, Sympathetic Nervous System, Baroreflex, Muscle, Skeletal, Abdominal Cavity

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