Cited by 150Viral Infections and Immunology ResearchCardiac Fibrosis and RemodelingOcular Diseases and Behçet’s Syndrome

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Interleukin-6–Deficient Mice Resist Development of Autoimmune Myocarditis Associated With Impaired Upregulation of Complement C3

Eriksson, Urs, Kurrer, Michael O., Schmitz, Nicole, Marsch, Stephan C., Fontana, Adriano, Eugster, Hans-Pietro, Kopf, Manfred·2003·Circulation

DOI 10.1161/01.cir.0000043802.38699.66

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Abstract

Background— Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis. Methods and Results— Using IL-6–deficient mice, we studied the role of IL-6 in a model of autoimmune myocarditis resulting from immunization with a peptide derived from cardiac α-myosin. Prevalence and severity of myocarditis were markedly reduced in the absence of IL-6. CD4 + T cells from immunized IL-6–deficient mice proliferated poorly on restimulation with specific antigen in vitro and did not mediate disease on adoptive transfer into IL-6–competent RAG-2–deficient mice, which otherwise lack B cells and T cells. Production of complement C3, a crucial factor for the development of myocarditis, was strongly upregulated in IL-6 +/+ but not in IL-6–deficient mice after immunization. Conclusions— Our results demonstrate that IL-6 is required for the expansion of autoimmune CD4 + T cells and the pathogenesis of autoimmune myocarditis, possibly by upregulation of complement C3.

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Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., & Ciliberto, G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.461 · Cited by 604
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Samoilova, E. B., Horton, J. L., Hilliard, B. A., Liu, T.-S. T., & Chen, Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6480 · Cited by 441
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Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8222 · Cited by 406
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Romani, L. R., Mencacci, A., Cenci, E., Spaccapelo, R., Toniatti, C., Puccetti, P., Bistoni, F., & Poli, V. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1345 · Cited by 308

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10.1161/circ.95.3.655 · DOI
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10.1161/circ.101.15.1767 · DOI
1998, Am J Physiol, 275, R1584
10.1161/res.86.3.281 · DOI

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Myers, J. M., Fairweather, D., Huber, S. A., & Cunningham, M. W. (2013) · Current Protocols in Immunology · doi:10.1002/0471142735.im1514s101 · Cited by 63
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Martens, C. R., & Accornero, F. (2021) · Viruses · doi:10.3390/v13101924 · Cited by 40
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Mikaelian, I., Coluccio, D., Morgan, K. T., Johnson, T., Ryan, A. L., Rasmussen, E., Nicklaus, R., Kanwal, C., Hilton, H., Frank, K. B., et al. (2008) · Toxicologic Pathology · doi:10.1177/0192623307312696 · Cited by 39
Prominin-1+/CD133+ bone marrow-derived heart-resident cells suppress experimental autoimmune myocarditis.
Kania, G., Błyszczuk, P., Valaperti, A., Dieterle, T., Leimenstoll, B., Dirnhofer, S., Zulewski, H., & Eriksson, U. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn190 · Cited by 44
Self-citation
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Pagni, P. P., Traub, S., Demaria, O., Chasson, L., & Alexopoulou, L. (2010) · Autoimmunity · doi:10.3109/08916930903509056 · Cited by 39
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis
Yuan, J., Yu, M., Li, H., Long, Q., Liang, W. H., Wen, S., Wang, M., Guo, H.-P., Cheng, X. C., & Liao, Y. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.11.008 · Cited by 37
Pitavastatin Regulates Helper T-Cell Differentiation and Ameliorates Autoimmune Myocarditis in Mice
Tajiri, K., Shimojo, N., Sakai, S., Machino‐Ohtsuka, T., Imanaka‐Yoshida, K., Hiroe, M., Tsujimura, Y., Kimura, T., Sato, A., Yasutomi, Y., et al. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6464-y · Cited by 36
Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger
Zhong, X. (2004) · International Immunology · doi:10.1093/intimm/dxh121 · Cited by 34
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Li, Y., Guang-Yi, C., Li‐Sha, G., Chao, X., Xinqiao, T., Cong, L., Xiao-Ya, D., & Yang, X. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00408 · Cited by 33
Lack of IL-6 during Coxsackievirus Infection Heightens the Early Immune Response Resulting in Increased Severity of Chronic Autoimmune Myocarditis
Poffenberger, M., Straka, N., Warry, N. E., Fang, D.-N., Shanina, I., & Horwitz, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006207 · Cited by 34
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Pistulli*, R., Andreas, E., König, S., Drobnik, S., Kretzschmar, D., Rohm, I., Lichtenauer, M., Heidecker, B., Franz, M., Mall, G., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12767 · Cited by 27
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Xie, Y., Li, M., Wang, X., Zhang, X., Peng, T., Yang, Y., Zou, Y., Ge, J., Chen, H., & Chen, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072158 · Cited by 26
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Pan, J.-P., Liu, T.-Y., Chiang, S. C., Lin, Y., Chou, C. Y., Chan, W., & Lai, S. (2004) · PubMed · Cited by 24
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Teruel, A., Romero‐Reyes, M., Cacalano, N. A., Head, C. S., & Jewett, A. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0375-3 · Cited by 23
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Syriga, M., & Mavroidis, M. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-4118-2_14 · Cited by 19
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Lu, H., Wu, Y. R., Shao, X., Zhou, S., Jiang, Y., Chen, R., Zong, G., Xu, H., & Su, Z. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0617-264rr · Cited by 15
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Avalle, L., Marino, F., Camporeale, A., Guglielmi, C., Viavattene, D., Bandini, S., Conti, L., Cimino, J. J., Forni, M., Zanini, C., et al. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.05.023 · Cited by 14
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Abel, B., Kurrer, M. O., Shamshiev, A. T., Marty, R. R., Eriksson, U., Günthert, U., & Köpf, M. (2006) · European Journal of Immunology · doi:10.1002/eji.200535618 · Cited by 15
Self-citation
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Grabmaier, U., Kania, G., Kreiner, J., Grabmeier, J., Uhl, A., Huber, B. C., Lackermair, K., Herbach, N., Todica, A. S., Eriksson, U., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158299 · Cited by 15
Self-citation
HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming
Jiang, Y., Chen, R., Shao, X., Ji, X., Lu, H., Zhou, S., Zong, G., Xu, H., & Su, Z. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.013 · Cited by 14

Authors: Eriksson, U., Kurrer, M. O., Schmitz, N., Marsch, S. C., Fontana, A., Eugster, H.-P., & Kopf, M.
Affiliations: University Hospital of Basel (CH)
From the Department of Internal Medicine (U.E., S.C.M.), University Hospital, Basel; Departments of Pathology (M.O.K.) and Clinical Immunology (A.F., H.-P.E.), University Hospital, Zurich; and Molecular Biomedicine (N.S., M.K.), Swiss Federal Institute of Technology, Zurich, Switzerland.
ORCID: Eriksson, Urs
Kurrer, Michael O.
Marsch, Stephan C.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-01-21
Volume: 107
Issue: 2
Pages: 320-325
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000043802.38699.66
OpenAlex: W2022616509
Cited by: 150
References: 32
Citations by year: 2026: 6 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 13
FWCI: 4.96
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: Schweizerische Herzstiftung
Helmut Horten Stiftung
Topics: Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: interleukin-6, autoimmune myocarditis, complement C3, CD4+ T cells, IL-6-deficient mice, dilated cardiomyopathy, T cell proliferation, adoptive transfer
MeSH terms: Animals, Autoantibodies, Autoimmune Diseases, B-Lymphocytes, Cell Division, Cells, Cultured, Complement C3, Disease Models, Animal, Disease Susceptibility, DNA-Binding Proteins, Immunization, Immunohistochemistry, Mice, Inbred BALB C, Myocarditis, Myocardium, Peptide Fragments, Tumor Necrosis Factor-alpha, CD4-Positive T-Lymphocytes, Interleukin-6, Up-Regulation, Mice, Knockout, Adoptive Transfer, Ventricular Myosins, Mice

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Interleukin-6–Deficient Mice Resist Development of Autoimmune Myocarditis Associated With Impaired Upregulation of Complement C3

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