The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine
Open accessAbstract
Regenerative medicine is a pioneering field aimed at restoring and regenerating the function of damaged cells, organs and tissues in order to establish normal function. It demands the cross communication of disciplines to develop effective therapeutic stem cell based therapies. Nanotechnology has been instrumental in the development and translation of basic research to the clinically relevant therapies. In particular, magnetic nanoparticles (MNPs) have been applied to tag, track and activate stem cells offering an effective means of monitoring in vitro and in vivo behaviour. MNPs are comprised of an iron oxide core with a biocompatible biological polymer. Safety is an issue of constant concern and emphasises on the importance of investigating the issue of toxicity. Any indication of toxicity can ultimately limit the therapeutic efficiency of the therapy. Toxicity is highly dependent on the physical, chemical and structural properties of the MNP itself as well as dose and intended use. Few in vitro studies have reported adverse effects of MNP on cells at in vitro in therapeutic doses. However, long term in vivo studies have not been studied as extensively. This review aims to summarise current research in this topic highlighting commonly used toxicity assays to investigate this.
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Cites
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“Organic and inorganic polymers including RGD peptides, fibronectin, and dextran can be used to coat the magnetic core resulting in improved biocompatibility by protecting biological entities from adverse toxic reactions [14, 17].”
BackgroundInfluentialLaurent, S., Burtea, C., Thirifays, C., Häfeli, U. O., & Mahmoudi, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029997 · Cited by 171
Cited by
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Recent progress of magnetic nanoparticles in biomedical applications: A review
Anik, M. I., Hossain, M. K., Hossain, I., Mahfuz, A. M. U. B., Rahman, M. T., & Ahmed, I. (2021) · Nano Select · doi:10.1002/nano.202000162 · Cited by 300
Stepien, G., Moros, M., Pérez-Hernández, M., Monge, M., Gutiérrez, L., Fratila, R. M., las Heras, M. D., Menao Guillén, S., Puente Lanzarote, J. J., Solans, C., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18648 · Cited by 158
Synthesis and characterization of magnetite nanoparticles coated with lauric acid
Mamani, J. B., Costa-Filho, A. J., Cornejo, D. R., Vieira, E. D., & Gamarra, L. F. (2013) · Materials Characterization · doi:10.1016/j.matchar.2013.04.001 · Cited by 116
The use of magnetic nanoparticles in cancer theranostics: Toward handheld diagnostic devices
Hajba, L., & Guttman, A. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.02.001 · Cited by 111
Metadata
- Authors
- Markides, H., Rotherham, M., & El Haj, A. J.
- Venue
- Journal of Nanomaterials
- Publisher
- Wiley
- Published
- 2012-01
- Volume
- 2012
- Issue
- 1
- ISSN
- 1687-4110 (ISSN-L)
- 1687-4129
- OpenAlex
- W2111596670
- Cited by
- 332
- References
- 6
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
