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Cited by 329

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Interleukin-18 and the Risk of Coronary Heart Disease in European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME)

Open access
Blankenberg, Stefan, Luc, Gérald, Ducimetière, Pierre, Arveiler, Dominique, Ferrières, Jean, Amouyel, Philippe, Evans, Alun, Cambien, François, Tiret, Laurence·2003·Circulation
DOI 10.1161/01.cir.0000099509.76044.a2
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Abstract

Background— Interleukin (IL)-18 promotes atherosclerotic plaque growth and vulnerability. It is unknown, however, whether elevations of circulating IL-18 precede the onset of coronary events in apparently healthy individuals. Methods and Results— We evaluated the relationship between baseline plasma levels of IL-18 and the subsequent incidence of coronary events over a 5-year follow-up in the Prospective Epidemiological Study of Myocardial Infarction (PRIME),which included 10 600 healthy European men aged 50 to 59 years at baseline. Analysis was performed in a nested case-control manner comparing 335 cases with a coronary event to 670 age-matched controls. Baseline levels of IL-18 were significantly higher in men who developed a coronary event than in controls (225.1 versus 203.9 pg/mL, P =0.005). After adjustment for most potential confounders, including C-reactive protein, IL-6, and fibrinogen, the relative risk of future coronary events associated with increasing tertiles of IL-18 was 1.65 (95% CI 1.14 to 2.40, P =0.008) in Northern Ireland, 1.29 (95% CI 0.96 to 1.73, P =0.09) in France, and 1.42 (95% CI 1.13 to 1.79, P =0.003) in both populations combined ( P =0.31 for the test of homogeneity between populations). In all models, IL-18 made an independent contribution to the prediction of risk over lipids or other inflammatory markers such as C-reactive protein, IL-6, or fibrinogen. Conclusions— Plasma IL-18 level was identified as an independent predictor of coronary events in healthy, middle-aged European men. Determination of circulating IL-18 might improve the prediction of coronary events.

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Metadata

Authors
Blankenberg, S., Luc, G., Ducimetière, P., Arveiler, D., Ferrières, J., Amouyel, P., Evans, A., Cambien, F., & Tiret, L.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-11-18
Volume
108
Issue
20
Pages
2453-2459
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000099509.76044.a2
OpenAlex
W2105813877
Cited by
329
References
6
FWCI
6.45
Type
journal article
Language
en
Open access
bronze

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