Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity
Abstract
Background Morbid obesity is associated with insulin resistance (IR), chronic inflammation and premature atherosclerosis. Since vascular inflammation may contribute to the increased risk of cardiovascular morbidity and mortality of these patients, we studied circulating Interleukin-18 (L-18) and monocyte-chemoattractant-protein-1 (MCP-1) levels in 37 patients with morbid obesity before and after significant weight loss induced by bariatric surgery and their preoperative and postoperative associations with C-reactive protein (CRP) and IR-associated factors.Methods High sensitivity assays were used to measure concentrations of fasting CRP, IL-18 and MCP-1. Differences between patients before and after bariatric surgery were analyzed by Student's paired t-test. To investigate the associations of the observed reductions of values, delta of parameters were calculated and preoperative, postoperative and delta data were tested by univariate and multivariate linear regression.Results After a mean follow-up period of 26.5 months and a massive weight loss of 35 kg induced by bariatric surgery, circulating IL-18 levels decreased by 37% (P<0.001) and circulating MCP-1 levels by 47% (P<0.001). Multiple linear regression of delta values of IL-18 showed that only 2-hour glucose (P=0.008) remained independently and significantly associated with IL-18, whereas multiple linear regression analysis of delta values of MCP-1 revealed that only delta of HOMA-IR (P<0.001) remained independently and significantly associated with MCP-1, respectively.Conclusions Because both biomarkers have been shown to play an important role in the development and progression of atherosclerosis, the observations presented in this study could be of clinical relevance for morbidly obese patients undergoing bariatric surgery.
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MCP-1 fell by over 50% following bariatric surgery in a 2006 study.
“In a study published in 2006 [14], monocyte chemoattractant protein-1 (MCP-1) fell remarkably (by over 50%) following bariatric surgery.”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [14]
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The Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy
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Effects of incretin therapy and bariatric surgery on inflammation in obese patients
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OBESITY, INFLAMMATION, VASCULAR REACTIVITY, AND CARDIOCIRCULATORY EVENTS
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- Authors
- Schernthaner, G.-H., Kopp, H.-P., Kriwanek, S., Krzyzanowska, K., Satler, M., Koppensteiner, R., & Schernthaner, G.
- Affiliations
- Medical University of Vienna (AT)
- Krankenanstalt Rudolfstiftung der Stadt Wien (AT)
- Venue
- Obesity Surgery
- Published
- 2006-06-01
- Volume
- 16
- Issue
- 6
- Pages
- 709-715
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2121445706
- Cited by
- 83
- References
- 26
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Keywords
- morbid obesity, bariatric surgery
- MeSH terms
- Adult, C-Reactive Protein, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Morbid, Weight Loss, Body Mass Index, Linear Models, Chemokine CCL2, Postprandial Period, Interleukin-18, Bariatric Surgery
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