Asymmetrical Dimethylarginine: The Über Marker?

Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease

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Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction: Its Role in Hypercholesterolemia

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Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study

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Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease

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Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.

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Endogenous Nitric Oxide Synthase Inhibitor

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NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease

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Human Immunodeficiency Virus–Associated Pulmonary Arterial Hypertension

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The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

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Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of l-[guanidino-15N2]-arginine to 15N-labeled nitrate by gas chromatography–mass spectrometry

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High Plasma Dimethylarginine Levels are Associated with Adverse Clinical Outcome After Stroke

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Inhibition of Human Dimethylarginine Dimethylaminohydrolase-1 by S-Nitroso-L-homocysteine and Hydrogen Peroxide

Lin, H., & Fast, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707231200 · Cited by 55

Progression of renal fibrosis: the underestimated role of endothelial alterations

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Nitric oxide status in patients with chronic kidney disease

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Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome

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The issue of plasma asymmetric dimethylarginine reference range – A systematic review and meta-analysis

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Ranolazine improves endothelial function in patients with stable coronary artery disease

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Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow

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Hemodynamic and Biologic Determinates of Arteriovenous Fistula Outcomes in Renal Failure Patients

Hammes, M. S. (2015) · BioMed Research International · doi:10.1155/2015/171674 · Cited by 50

Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort

Maas, R., Xanthakis, V., Polak, J. F., Schwedhelm, E., SULLIVAN, L. M., Benndorf, R. A., Schulze, F., Vasan, R. S., Wolf, P. A., Böger, R. H., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.552539 · Cited by 49

The administration of estrogens, combined with anti-androgens, has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels, in women with the polycystic ovary syndrome

Charitidou, C., Farmakiotis, D., Zournatzi, V., Pidonia, I., Pegiou, T., Karamanis, N., Hatzistilianou, M. N., Katsikis, I., & Panidis, D. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.03.002 · Cited by 49

DDAH Says NO to ADMA

Cooke, J. P., & Ghebremariam, Y. T. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.228833 · Cited by 49

Schistosome infection and its effect on pulmonary circulation

BUTROUS, G. S. (2019) · Global Cardiology Science and Practice · doi:10.21542/gcsp.2019.5 · Cited by 49

Distribution of Asymmetric Dimethylarginine among 980 Healthy, Older Adults of Different Ethnicities

Sydow, K., Fortmann, S. P., Fair, J. M., Varady, A. N., Hlatky, M. A., Go, A. S., Iribarren, C., Tsao, P. S., & for the ADVANCE Investigators (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.136200 · Cited by 47

Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE‐COARCT Study

Martins, J. D., Zachariah, J. P. V., Tierney, E. S. S., Truong, U. T., Morris, S. A., Kutty, S., de Ferranti, S. D., Guarino, M. P., Thomas, B., Oliveira, D., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.011536 · Cited by 47

Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats

Carello, K. A., Whitesall, S. E., Lloyd, M. C., Billecke, S. S., & D’Alecy, L. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00208.2005 · Cited by 46

Proton pump inhibitors and vascular function: A prospective cross-over pilot study

Ghebremariam, Y. T., Cooke, J. P., Khan, F., Thakker, R., Chang, P., Shah, N. H., Nead, K. T., & Leeper, N. J. (2015) · Vascular Medicine · doi:10.1177/1358863x14568444 · Cited by 45

Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia

Maas, R., Quitzau, K., Schwedhelm, E., Spieker, L. E., Rafflenbeul, W., Steenpaß, A., Lüscher, T. F., & Böger, R. H. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.024 · Cited by 45

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines

Antoniades, C. A., Tousoulis, D., Marinou, K., Vasiliadou, C., Tentolouris, C., Bouras, G., Pitsavos, C. E., & Stefanadis, C. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.781 · Cited by 45

Contribution of whole blood to the control of plasma asymmetrical dimethylarginine

Billecke, S. S., Kitzmiller, L. A., Northrup, J. J., Whitesall, S. E., Kimoto, M., Hinz, A. V., & D’Alecy, L. G. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00066.2006 · Cited by 44

Role of Nitric Oxide Signaling in Endothelial Differentiation of Embryonic Stem Cells

Huang, N. F., Fleißner, F., Sun, J. S., & Cooke, J. P. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0417 · Cited by 43

Plasma ADMA Predicts Restenosis of Arteriovenous Fistula

Wu, C., Wen, S., Yang, C., Pu, S.-Y., Tsai, K.-C., & Chen, J.-W. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008050476 · Cited by 43

l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation

Menzel, D., Haller, H. G., Wilhelm, M. G., & Robenek, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1342-6 · Cited by 43

Body size, but neither age nor asymptomatic mitral regurgitation, influences plasma concentrations of dimethylarginines in dogs

Pedersen, L. G., Tarnow, I., Olsen, L. H., Teerlink, T., & Pedersen, H. D. (2005) · Research in Veterinary Science · doi:10.1016/j.rvsc.2005.07.005 · Cited by 43

Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation

Horowitz, J. D., Caterina, R. D., Heresztyn, T., Alexander, J. H., Andersson, U., Lópes, R. D., Steg, P. G., Hylek, E. M., Mohan, P., Hanna, M., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.058 · Cited by 42

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1‐dependent mechanism in mice

Hasegawa, K., Wakino, S., Kimoto, M., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Tokuyama, H., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-226092 · Cited by 42

Dimethylarginine Levels in Cerebrospinal Fluid of Hyperacute Ischemic Stroke Patients are Associated with Stroke Severity

Brouns, R., Marescau, B., Possemiers, I., Sheorajpanday, R. V. A., & Deyn, P. P. D. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9954-3 · Cited by 42

Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery

Maas, R., Dentz, L., Schwedhelm, E., Thoms, W., Kuß, O., Hiltmeyer, N., Haddad, M., KLÖSS, T., Standl, T. G., & Böger, R. H. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000277038.11630.71 · Cited by 41

The past, presence and future of ADMA in nephrology

Kielstein, J. T., & Fliser, D. (2007) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2007.02.002 · Cited by 41

Determination of Asymmetric Dimethylarginine: Liquid Chromatography–Mass Spectrometry or ELISA?

Martens‐Lobenhoffer, J., Westphal, S., Awiszus, F., Bode‐Böger, S. M., & Luley, C. H. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.056788 · Cited by 40

Improving Proteinuria, Endothelial Functions and Asymmetric Dimethylarginine Levels in Chronic Kidney Disease: Ramipril versus Valsartan

Yılmaz, M. İ., Sağlam, M., Sönmez, A., Çağlar, K., Çakır, E., Kurt, Y., Eyileten, T., Taşar, M., Açıkel, C., Oğuz, Y., et al. (2007) · Blood Purification · doi:10.1159/000107410 · Cited by 40

ADMA: an emerging cardiovascular risk factor

Böger, R. H., Cooke, J. P., & Vallance, P. J. (2005) · Vascular Medicine · doi:10.1177/1358836x0501000101 · Cited by 40

Mass spectrometric quantification of L-arginine and its pathway related substances in biofluids: The road to maturity

Martens‐Lobenhoffer, J., & Bode‐Böger, S. M. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.10.030 · Cited by 39

L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure

Brenner, T., Fleming, T. H., Rosenhagen, C., Krauser, U., Mieth, M., Bruckner, T. M., Martin, E., Nawroth, P. P., Weigand, M. A., Bierhaus, A., et al. (2012) · Mediators of Inflammation · doi:10.1155/2012/210454 · Cited by 39

Effects of Rosuvastatin on Asymmetric Dimethylarginine Levels and Early Atrial Fibrillation Recurrence after Electrical Cardioversion

Xia, W., YIN, Z., Li, J., Song, Y., & Qu, X.-F. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02554.x · Cited by 39

Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status.

Jabecka, A., Ast, J., Bogdaski, P., Drozdowski, M., Pawlak-Lemaska, K., Cielewicz, A. R., & Pupek‐Musialik, D. (2012) · PubMed · Cited by 39

The Prominent Role of the Liver in the Elimination of Asymmetric Dimethylarginine (ADMA) and the Consequences of Impaired Hepatic Function

Richir, M. C., Bouwman, R. H., Teerlink, T., Siroen, M. P. C., de Vries, T. P. G. M., & van Leeuwen, P. A. M. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108321702 · Cited by 39

Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor--evidence from epidemiological and prospective clinical trials.

Szuba, A., & Podgórski, M. (2006) · PubMed · Cited by 39

Oxidative Stress and Asymmetric Dimethylarginine Are Associated with Cardiovascular Complications in Hemodialysis Patients: Improvements by L-Arginine Intake

EL-Mesallamy, H. O., AbdelHamid, S. G., & Gad, M. Z. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000135655 · Cited by 38

Biochemical and Biological Aspects of Protein Thiolation in Cells and Plasma

Simplicio, P. D., Frosali, S., Priora, R., Summa, D., Simplicio, F. C. D., Giuseppe, D. D., & Stefano, A. D. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.951 · Cited by 39

Chronic kidney disease measures for cardiovascular risk prediction

Mok, Y., Ballew, S. H., & Matsushita, K. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.09.007 · Cited by 37

Biological variation of asymmetric dimethylarginine and related arginine metabolites and analytical performance goals for their measurement in human plasma

Blackwell, S., O’Reilly, D. S. J., & Talwar, D. K. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01798.x · Cited by 37

Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1*

Rafikov, R., Rafikova, O., Aggarwal, S., Gross, C., Sun, X., Desai, J., Fulton, D., & Black, S. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.423269 · Cited by 36

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L‐arginine in patients with arteriogenic and non‐arteriogenic erectile dysfunction

Paroni, R. C., Barassi, A., Ciociola, F., Dozio, E., Finati, E., Fermo, I., Ghilardi, F., Colpi, G. M., Romanelli, M. M. C., & d’Eril, G. V. M. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01272.x · Cited by 36

Suitability of biomarkers of biological effects (BOBEs) for assessing the likelihood of reducing the tobacco related disease risk by new and innovative tobacco products: A literature review

Scherer, G. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.02.002 · Cited by 37

Inflammation‐regulatory microRNAs: Valuable targets for intracranial atherosclerosis

Li, J., Li, K., & Chen, X. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24487 · Cited by 36

Elevation of Asymmetrical Dimethylarginine (ADMA) and Coronary Artery Disease in Men with Erectile Dysfunction

Maas, R., Wenske, S., Zabel, M., Ventura, R., Schwedhelm, E., Steenpaß, A., Klemm, H. U., Noldus, J., & Böger, R. H. (2005) · European Urology · doi:10.1016/j.eururo.2005.07.017 · Cited by 36

Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice

Veldink, H., Faulhaber‐Walter, R., Park, J.-K., Martens‐Lobenhoffer, J., Bode‐Böger, S. M., Schuett, H., Haghikia, A., Hilfiker‐Kleiner, D., & Kielstein, J. T. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs554 · Cited by 35

Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment

Kılıç, S., Yılmaz, N., Zülfikaroğlu, E., Erdoğan, G., Aydın, M., & Batıoğlu, S. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.530706 · Cited by 35

Putative Role of Asymmetric Dimethylarginine in Microvascular Disease of Kidney and Heart in Hypertensive Patients

Fujii, H., Takiuchi, S., Kawano, Y., & Fukagawa, M. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.29 · Cited by 35

Decreased levels of asymmetric dimethylarginine during acute hyperinsulinemia

Eid, H. M. A., Reims, H. M., Arnesen, H., Kjeldsen, S. E., Lyberg, T., & Seljeflot, I. (2007) · Metabolism · doi:10.1016/j.metabol.2006.11.003 · Cited by 35

The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine

Løland, K. H., Bleie, Ø., Borgeraas, H., Strand, E., Ueland, P. M., Svardal, A. M., Nordrehaug, J. E., & Nygard, O. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064774 · Cited by 34

An Association Between Plasma Asymmetric Dimethylarginine and Membrane Fluidity of Erythrocytes in Hypertensive and Normotensive MenAn Electron Paramagnetic Resonance Investigation

Tsuda, K., & Nishio, I. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.04.007 · Cited by 34

Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction

Ioakeimidis, N., Vlachopoulos, C. V., Rokkas, K., Aggelis, A., Terentes-Printzios, D. G., Samentzas, A., Alexopoulos, N. A., & Stefanadis, C. (2011) · European Urology · doi:10.1016/j.eururo.2011.02.008 · Cited by 33

Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl‐L‐arginine and structurally related amino acids: Quantitation in human plasma

Trapp, G., Sydow, K., Dulay, M. T., Chou, T., Cooke, J. P., & Zare, R. N. (2004) · Journal of Separation Science · doi:10.1002/jssc.200401918 · Cited by 33

Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis

Mangiacapra, F., Conte, M., Demartini, C., Müller, O., Delrue, L., Dierickx, K., Sciascio, G. D., Trimarco, B., Bruyne, B. D., Wijns, W. C., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.254 · Cited by 33

Transcriptional control of human adipose tissue blood flow

Perez‐Matute, P., Neville, M. J., Tan, G. D., Frayn, K. N., & Karpe, F. (2009) · Obesity · doi:10.1038/oby.2008.606 · Cited by 32

Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome

Soyman, Z., Noyan, V., Tulmaç, M., Yücel, A., Sağsöz, N., Bayrak, T., Bayrak, A., & Çakır, E. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.011 · Cited by 32

Determination of cerebrospinal fluid concentrations of arginine and dimethylarginines in patients with subarachnoid haemorrhage

Martens‐Lobenhoffer, J., Sulyok, E., Czeiter, E., Büki, A., Kohl, J., Firsching, R. P., Tröger, U., & Bode‐Böger, S. M. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.04.005 · Cited by 31

Hypertension in Chronic Kidney Disease and Dialysis: Pathophysiology and Management

Agarwal, R. (2005) · Cardiology Clinics · doi:10.1016/j.ccl.2005.03.003 · Cited by 31

Clinical Epidemiology of Major Nontraditional Risk Factors in Peritoneal Dialysis Patients

Zoccali, C., Enia, G., Tripepi, G. L., Panuccio, V. A., & Mallamaci, F. (2005) · Peritoneal Dialysis International · doi:10.1177/089686080502503s21 · Cited by 31

Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives

Thomopoulos, C., Tsioufis, C. P., Dimitriadis, K. S., Tsiachris, D., Tousoulis, D., Manolis, A., Alchanatis, M., Kallikazaros, I. E., & Stefanadis, C. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.101 · Cited by 30

Detection and quantification of α-keto-δ-(N,N-dimethylguanidino)valeric acid: A metabolite of asymmetric dimethylarginine

Martens‐Lobenhoffer, J., Rodionov, R. N., Drust, A., & Bode‐Böger, S. M. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.08.044 · Cited by 29

ADMA regulates angiogenesis: genetic and metabolic evidence

Achan, V., Ho, H. –. V., Heeschen, C., Stuehlinger, M., Jang, J. J., Kimoto, M., Vallance, P. J., & Cooke, J. P. (2005) · Vascular Medicine · doi:10.1191/1358863x05vm580oa · Cited by 29

Relationship of asymmetric dimethylarginine with flow‐mediated dilatation in subjects with newly detected severe hypercholesterolemia

Vladimirova‐Kitova, L., Deneva, T., Angelova, E., Nikolov, F. P., Marinov, B. I., & Mateva, N. G. (2008) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2008.00825.x · Cited by 29

The Role of Olive Oil in Cardiometabolic Risk

Salvo, A., & Tuttolomondo, A. (2025) · Metabolites · doi:10.3390/metabo15030190 · Cited by 29

A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue

Maas, R., Tan-Andresen, J., Schwedhelm, E., Schulze, F., & Böger, R. H. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.01.020 · Cited by 28

Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima–media thickness and endothelium-dependent vasodilation

Özalper, V., Kara, M., Tanoğlu, A., Cetindağlı, I., Öztürker, C., Hançerli, Y., Hıra, S., Kara, K., Beyazıt, Y., & Yazgan, Y. (2017) · Clinical Rheumatology · doi:10.1007/s10067-016-3532-2 · Cited by 28

Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children

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