Transcriptional control of human adipose tissue blood flow
Open accessAbstract
Adipose tissue is highly vascularized and expresses several genes involved in vasodilatory and vasoconstrictive regulation. We took a transcriptional approach to study the relationships between adipose tissue blood flow (ATBF) and genes involved in vasoactive processes. As ATBF is impaired in obesity, we tested whether body weight interfered with the transcriptional regulation of ATBF. The mRNA content (real-time PCR) of 26 genes was quantified in subcutaneous adipose tissue biopsies from 28 healthy men with a wide range of BMI. ATBF was measured by 133Xe washout. None of the transcripts was related to fasting ATBF (ATBFF). However, the expression levels of two transcripts involved in vasodilation (natriuretic peptide receptor A/guanylate cyclase A (NPRA) and endothelial nitric oxide synthase (eNOS)) were positively associated with postprandial ATBF (r = 0.53 and r = 0.55, P < 0.01, respectively). Although BMI was negatively related to the mRNA content of NPRA and eNOS (r = -0.78 and r = -0.63, P < 0.01, respectively), the strong associations found between postprandial ATBF and the two transcripts were not affected by obesity. Several genes were subject to coordinated regulation of expression. This study demonstrates for the first time that ATBF responsiveness to nutrient intake is related to the transcription of two genes expressed in adipose tissue and directly involved in vasodilatory actions (eNOS and NPRA), suggesting that part of the regulation of ATBF is at a transcriptional level. Interestingly, these associations were not secondary to changes in BMI. We also found that certain genes involved in the regulation of ATBF are subject to coordinate regulation of expression suggesting physiological autoregulation.
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Lower NOS3 abundance is found in both adipose tissue and skeletal muscle of obese humans and rodents.
“lower NOS3 abundance is found in both adipose tissue and skeletal muscle of obese humans and rodents [120-124].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [121]
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“, 2006) and humans (Perez-Matute et al., 2009; Georgescu et al., 2011), while its overexpression prevented diet-induced obesity, increased metabolic activity and promoted brown adipose tissue-like phenotype in white adipose tissue in mice (Sansbury et al.”
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“…high fat diet (HFD)induced weight gain (Shankar et al., 2000; Duplain et al., 2001; Cook et al., 2003), and, the abundance of eNOS is remarkably diminished in obesity and diabetes (Valerio et al., 2006; Perez-Matute et al., 2009; Georgescu et al., 2011; Kraus et al., 2012; Sansbury et al., 2012).”
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“However, other studies have shown that, as obesity sets in, eNOS expression and function decreases (7), which probably reflects ensuing endothelial dysfunction with increasing body mass index (BMI).”
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“…(controlþa-LA) (n¼ 10), fed ad libitum with the previously mentioned standard diet supplemented with a-LA in a proportion of 0.25 g a-LA/100 g of diet (Perez-Matute et al. 2009; Prieto-Hontoria et al. 2009) and finally (iii) pair-fed CLIP group (PFC) (n¼ 6) fed with the same amount of food…”
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- Authors
- Perez‐Matute, P., Neville, M. J., Tan, G. D., Frayn, K. N., & Karpe, F.
- Affiliations
- Churchill Hospital (GB)
- Corresponding author
- Karpe, Fredrik
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-04
- Volume
- 17
- Issue
- 4
- Pages
- 681-688
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2009850045
- Cited by
- 32
- References
- 43
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- RIUR (Universidad de La Rioja) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue blood flow, transcriptional regulation, vasodilation, endothelial nitric oxide synthase, natriuretic peptide receptor A, guanylate cyclase A, postprandial blood flow, body mass index, subcutaneous adipose tissue, gene expression, autoregulation
- MeSH terms
- Algorithms, Humans, Male, Middle Aged, Models, Biological, Obesity, Regional Blood Flow, Transcription, Genetic, Vasodilation, Body Mass Index, Receptors, Atrial Natriuretic Factor, Postprandial Period, Subcutaneous Fat, Overweight, Nitric Oxide Synthase Type III
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