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Asymmetrical Dimethylarginine: The Über Marker?
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“Cardiovascular risk factors (e.g., hypercholesterolemia, diabetes mellitus) impair the synthesis and bioactivity of endothelium-derived NO (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]
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“Their adverse effect on the NOS pathway is mediated by asymmetric dimethylarginine (ADMA; the endogenous antagonist of NO synthesis) and by the vascular generation of superoxide anion (O 2 -), which degrades NO to peroxynitrite anion (ONOO -) (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]
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Fernández-Macías, J. C., Ochoa-Martínez, A. C., Varela-Silva, J. A., & Pérez-Maldonado, I. N. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.08.009 · Cited by 458
Metadata
- Authors
- Cooke, J. P.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cooke, John P.
- ORCID
- Cooke, John P.
- Venue
- Circulation
- Published
- 2004-04-20
- Volume
- 109
- Issue
- 15
- Pages
- 1813-1818
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2132464590
- Cited by
- 396
- References
- 85
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 4 · 2019: 14 · 2018: 16 · 2017: 13 · 2016: 18 · 2015: 10 · 2014: 17 · 2013: 21 · 2012: 26
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tobacco-Related Disease Research Program
- National Institute on Aging (P01 AG18784, P01AG018784)
- National Heart, Lung, and Blood Institute (R01 HL00204, R01 HL-HL63685, R01 HL, R01HL063685)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- asymmetric dimethylarginine, nitric oxide bioavailability, endothelial dysfunction, oxidative stress, nitric oxide synthase
- MeSH terms
- Amidohydrolases, Arginine, Arteriosclerosis, Blood Vessels, Endothelium, Vascular, Humans, Risk Factors, Vascular Resistance, Biomarkers, Nitric Oxide Synthase
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