Cited by 266Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in CancerEicosanoids and Hypertension Pharmacology

NO and angiogenesis

Cooke, John P.·2003·Atherosclerosis Supplements

Abstract

Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic factors induce the release of NO from endothelial cells, which mediates a multiplicity of processes involved in angiogenesis. These NO-modulated processes include endothelial cell survival, proliferation, migration, and interaction with the extracellular matrix. Derangements of the NO synthase pathway impair angiogenesis. Accordingly, the competitive inhibitor of the NOS pathway asymmetric dimethylarginine (ADMA) acts as an endogenous inhibitor of angiogenesis. By contrast, agents which increase NO synthesis, such as low dose statins, enhance angiogenesis. Modulation of the NO synthase pathway could become a new therapeutic avenue for angiogenesis-related disorders.

Integrity signals

Registry

Crossref · 10.1016/s1567-5688(03)00034-5

Cites

77 of 77 references verified0 citation errors · 0 not checkable

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  • Multiple reports indicate that nitric oxide serves as an angiogenic signaling molecule, up-regulating VEGF production and increasing blood vessel growth.

    “Multiple reports indicate that NO serves as an angiogenic signaling model, up-regulating VEGF production and increasing blood vessel growth.213–214”

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Authors
Cooke, J. P.
Affiliations
Stanford Medicine (US)
Corresponding author
Cooke, John P.
Venue
Atherosclerosis Supplements
Publisher
Elsevier BV
Published
2003-12
Volume
4
Issue
4
Pages
53-60
ISSN
1567-5688 (ISSN-L)
OpenAlex
W2075124894
Cited by
266
References
78
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 17
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Locations
  • Atherosclerosis Supplements (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1z01hl000204-29)
  • National Institute on Aging (P01 AG18784, P01AG018784)
  • National Heart, Lung, and Blood Institute (R01 HL-63685, R01HL063685)
  • National Institute of Allergy and Infectious Diseases (P01AI050153, P01AI50153)
  • National Center for Complementary and Integrative Health (R01 AT/HL00204)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
nitric oxide, angiogenesis, endothelial cells, nitric oxide synthase, asymmetric dimethylarginine, endothelial cell migration, endothelial cell proliferation, endothelial cell survival, extracellular matrix, statins
MeSH terms
Arginine, Cardiovascular Diseases, Cell Movement, Cell Survival, Endothelium, Vascular, Enzyme Inhibitors, Humans, Nitric Oxide, Angiogenesis Inhibitors, Endothelial Cells

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