The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Open accessAbstract
Background— Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis. Methods and Results— Of 1056 persons (age 69±9 years) with no history of stroke or myocardial infarction enrolled in the Oral Infections and Vascular Disease Epidemiology Study (INVEST), we analyzed 657 dentate subjects. Among these subjects, 4561 subgingival plaque samples were collected (average of 7 samples/subject) and quantitatively assessed for 11 known periodontal bacteria by DNA-DNA checkerboard hybridization. Extensive in-person cardiovascular risk factor measurements, a carotid scan with high-resolution B-mode ultrasound, white blood cell count, and C-reactive protein values were obtained. In 3 separate analyses, mean carotid artery intima-media thickness (IMT) was regressed on tertiles of (1) burden of all bacteria assessed, (2) burden of bacteria causative of periodontal disease (etiologic bacterial burden), and (3) the relative predominance of causative/over other bacteria in the subgingival plaque. All analyses were adjusted for age, race/ethnicity, gender, education, body mass index, smoking, diabetes, systolic blood pressure, and LDL and HDL cholesterol. Overall periodontal bacterial burden was related to carotid IMT. This relationship was specific to causative bacterial burden and the dominance of etiologic bacteria in the observed microbiological niche. Adjusted mean IMT values across tertiles of etiologic bacterial dominance were 0.84, 0.85, and 0.88 ( P =0.002). Similarly, white blood cell values increased across tertiles of etiologic bacterial burden from 5.57 to 6.09 and 6.03 cells ×10 9 /L ( P =0.01). C-reactive protein values were unrelated to periodontal microbial status ( P =0.82). Conclusions— Our data provide evidence of a direct relationship between periodontal microbiology and subclinical atherosclerosis. This relationship exists independent of C-reactive protein.
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Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
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The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events
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The bacteria of periodontal diseases
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"Checkerboard" DNA-DNA hybridization.
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Self-citationPravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II)
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The Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke
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Cited by
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154
Lockhart, P. B., Bolger, A. F., Papapanou, P. N., Osinbowale, O., Trevisan, M., Levison, M. E., Taubert, K. A., Newburger, J. W., Gornik, H. L., Gewitz, M. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31825719f3 · Cited by 1,038
Self-citationIs there Such a thing as “Evidence-Based Management”?
Rousseau, D. M. (2006) · Academy of Management Review · doi:10.5465/amr.2006.20208679 · Cited by 965
A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Metadata
- Authors
- Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Sacco, R. L., & Papapanou, P. N.
- Venue
- Circulation
- Published
- 2005-02-08
- Volume
- 111
- Issue
- 5
- Pages
- 576-582
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2033431538
- Cited by
- 488
- References
- 31
- FWCI
- 42.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Sacco, R. L., & Papapanou, P. N. (2005). Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation. https://doi.org/10.1161/01.cir.0000154582.37101.15
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